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- W2912698297 abstract "Salivary duct carcinoma (SDCa) is a rare and aggressive head and neck cancer that is currently treated with radical surgery and adjuvant radiotherapy. However, patients regularly develop distant metastases and the overall survival is 24–36 months. Thus there is an unmet need for development of systemic therapy. Nearly 90% of SDCa demonstrate androgen receptor expression and 30% demonstrate HER2 amplification. However, treatment of small cohorts of SDCa targeting these has produced variable Results. The rarity of the entity precludes clinical trials. Here, we present a multi-institutional cohort of 41 primary salivary duct carcinomas including 33 males and 8 females with age range from 24 to 92 years. Targeted sequencing of 150 genes was performed on DNA extracted from FFPE specimens collected 2001–2018. Data analysis used in house refynr2 and Gentian analysis pipelines. Apart from HER2 amplification, many tumours showed mutations in various signalling pathways including the MAPK/ERK pathway. These pathways have targeted-therapies that have shown promising results in studies on other cancer types such as breast cancer. Personalised medical treatment based on the identification of mutations by DNA sequencing therefore harbours the potential to improve outcome in salivary duct carcinoma." @default.
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- W2912698297 date "2019-02-01" @default.
- W2912698297 modified "2023-09-24" @default.
- W2912698297 title "The targetable genomic landscape of salivary duct carcinoma" @default.
- W2912698297 doi "https://doi.org/10.1016/j.pathol.2018.12.210" @default.
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