FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912700233> ?p ?o ?g. }

• W2912700233 endingPage "S391" @default.
• W2912700233 startingPage "S390" @default.
• W2912700233 abstract "Background ATLL is an aggressive T cell malignancy with dismal prognosis which occurs mainly in Caribbean immigrants in the US. AlloSCT is an effective treatment option in eligible patients (pts). We sought to identify barriers to alloSCT for these pts in a tertiary center with one of the largest ATLL populations in the US. Methods Pts with ATLL treated at Montefiore Medical Center were identified from 2003 to 2018. Comprehensive review of charts and donor registry searches were conducted. Results We identified 88 pts, mean age 56 yrs, 7 (8%) with chronic/smoldering subtypes. Of pts with acute (49, 60.5%) or lymphomatous (32, 39.5%) types, 48 (59.5%) were not considered for alloSCT due to early death (52%, n=25), lost to follow up (19%, n=10), uninsured (13%, n=7), declined HSCT (9%, n=5) and frailty (2%, n=1). Of 33 (40.7%) pts evaluated for alloSCT, 28 (34.6%) underwent HLA typing. A 10/10 matched related donor (MRD) was identified in 7 (25%). Registry search for matched unrelated donors (MUD) in the remainder 21 showed 10/10 (9.5%, n=2), 9/10 (19%, n=4), 8/10 (9.5%, n=2) and none (62%, n=13). Haploidentical donors were identified for 6 of 13 (46%) pts with no MUD. No donor options were available for 7 (25%) HLA-typed pts. AlloSCT was performed in 10/21 (47.6%) pts. Reasons for not undergoing alloSCT were progressive disease (50%, n=9), and patient declination (11%, n=2). AlloHSCT was associated with better median relapse-free (RFS) (26 vs. 11 mo, p=0.04) and overall survival (OS) (47 vs. 10 mo, p=0.03). Early transplant-related mortality (TRM) rate was 40%. Pts transplanted in complete remission (CR) and with MRD/MUD had better outcomes. Conclusion This is the first study demonstrating the barriers for alloHSCT for ATLL in the US. Only 12.3% pts proceed to alloSCT in ATLL. Early mortality, lost to follow up, uninsured status, lack of available suitable donors, including haploidentical, are significant problems. In pts who have successful induction, alloSCT can achieve long term remissions. Hence, better upfront treatments to achieve CR, early alloSCT, and consolidation/maintenance strategies in those who do not proceed to alloSCT are urgently needed to improve outcomes in ATLL." @default.
• W2912700233 created "2019-02-21" @default.
• W2912700233 creator A5005190583 @default.
• W2912700233 creator A5015162148 @default.
• W2912700233 creator A5022054568 @default.
• W2912700233 creator A5024200471 @default.
• W2912700233 creator A5024806172 @default.
• W2912700233 creator A5025809322 @default.
• W2912700233 creator A5027641455 @default.
• W2912700233 creator A5040239548 @default.
• W2912700233 creator A5048939308 @default.
• W2912700233 creator A5055212021 @default.
• W2912700233 creator A5061052702 @default.
• W2912700233 creator A5068938453 @default.
• W2912700233 creator A5069996825 @default.
• W2912700233 date "2019-03-01" @default.
• W2912700233 modified "2023-09-27" @default.
• W2912700233 title "Barriers and Outcomes of Allogeneic Stem Cell Transplant (AlloSCT) for Human T Cell Lymphotropic Virus 1 (HTLV-1) Associated Adult T-Cell Lymphoma-Leukemia (ATLL) in the United States (US) from a Large Cohort in a Major Tertiary Center" @default.
• W2912700233 doi "https://doi.org/10.1016/j.bbmt.2018.12.800" @default.
• W2912700233 hasPublicationYear "2019" @default.
• W2912700233 type Work @default.
• W2912700233 sameAs 2912700233 @default.
• W2912700233 citedByCount "0" @default.
• W2912700233 crossrefType "journal-article" @default.
• W2912700233 hasAuthorship W2912700233A5005190583 @default.
• W2912700233 hasAuthorship W2912700233A5015162148 @default.
• W2912700233 hasAuthorship W2912700233A5022054568 @default.
• W2912700233 hasAuthorship W2912700233A5024200471 @default.
• W2912700233 hasAuthorship W2912700233A5024806172 @default.
• W2912700233 hasAuthorship W2912700233A5025809322 @default.
• W2912700233 hasAuthorship W2912700233A5027641455 @default.
• W2912700233 hasAuthorship W2912700233A5040239548 @default.
• W2912700233 hasAuthorship W2912700233A5048939308 @default.
• W2912700233 hasAuthorship W2912700233A5055212021 @default.
• W2912700233 hasAuthorship W2912700233A5061052702 @default.
• W2912700233 hasAuthorship W2912700233A5068938453 @default.
• W2912700233 hasAuthorship W2912700233A5069996825 @default.
• W2912700233 hasBestOaLocation W29127002331 @default.
• W2912700233 hasConcept C126322002 @default.
• W2912700233 hasConcept C141071460 @default.
• W2912700233 hasConcept C2778461978 @default.
• W2912700233 hasConcept C2779399171 @default.
• W2912700233 hasConcept C2911091166 @default.
• W2912700233 hasConcept C71924100 @default.
• W2912700233 hasConcept C90924648 @default.
• W2912700233 hasConceptScore W2912700233C126322002 @default.
• W2912700233 hasConceptScore W2912700233C141071460 @default.
• W2912700233 hasConceptScore W2912700233C2778461978 @default.
• W2912700233 hasConceptScore W2912700233C2779399171 @default.
• W2912700233 hasConceptScore W2912700233C2911091166 @default.
• W2912700233 hasConceptScore W2912700233C71924100 @default.
• W2912700233 hasConceptScore W2912700233C90924648 @default.
• W2912700233 hasIssue "3" @default.
• W2912700233 hasLocation W29127002331 @default.
• W2912700233 hasOpenAccess W2912700233 @default.
• W2912700233 hasPrimaryLocation W29127002331 @default.
• W2912700233 hasRelatedWork W1888111113 @default.
• W2912700233 hasRelatedWork W2088821386 @default.
• W2912700233 hasRelatedWork W2101610405 @default.
• W2912700233 hasRelatedWork W2319875494 @default.
• W2912700233 hasRelatedWork W2412478481 @default.
• W2912700233 hasRelatedWork W2567673387 @default.
• W2912700233 hasRelatedWork W2886881768 @default.
• W2912700233 hasRelatedWork W2943787687 @default.
• W2912700233 hasRelatedWork W4223580296 @default.
• W2912700233 hasRelatedWork W4253315410 @default.
• W2912700233 hasVolume "25" @default.
• W2912700233 isParatext "false" @default.
• W2912700233 isRetracted "false" @default.
• W2912700233 magId "2912700233" @default.
• W2912700233 workType "article" @default.