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- W2912702295 abstract "Postencephalitic parkinsonism is a progressive neurodegenerative disease with clinical features referable mainly to the extrapyramidal and oculomotor systems. It represents the most common (and only permanent) sequel of encephalitis lethargica and clinically may resemble idiopathic Parkinson's disease. Morphologically it is characterized by severe neuronal depletion and gliosis in many brainstem nuclei, in particular the substantia nigra, associated with widespread globose neurofibrillary tangles and tau-positive glial inclusions that are usually immunoreactive for both three- and four-repeat tau isoforms. Postencephalitic parkinsonism shares histopathological features with other tauopathies as a multisystem degeneration with tau-positive neurofibrillary tangles that have biochemical and ultrastructure features similar to Alzheimer's disease while α-synuclein and TDP-43 pathologies are absent. Postencephalitic parkinsonism differs both clinically and morphologically from both idiopathic Parkinson's disease and other tau-related movement disorders. There is no known genetic factor associated with postencephalitic parkinsonism and its etiopathogenesis is still unknown; despite its suggested relationship with EL, recent research has failed to identify a causative agent." @default.
- W2912702295 created "2019-02-21" @default.
- W2912702295 creator A5042083351 @default.
- W2912702295 date "2011-09-02" @default.
- W2912702295 modified "2023-09-25" @default.
- W2912702295 title "Postencephalitic Parkinsonism" @default.
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- W2912702295 doi "https://doi.org/10.1002/9781444341256.ch19" @default.
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