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• W2912704706 abstract "The biological roles of interleukin (IL)-21 in human monocytes and macrophages have been neglected. We previously demonstrated that IL-21 induce phagocytosis and established that Syk is a new molecular target of IL-21. Herein, we found that IL-21 is not chemoattractant for immature THP-1 and primary monocytes but can increase the capacity of THP-1 cells (not primary monocytes) to adhere onto a cell substratum by a Syk-dependent mechanism without altering the expression of a panel of cell surface molecules. Unlike THP- 1 and monocytes, IL-21 can increase metalloproteinase (MMP)-9 secretion and activity in monocyte-derived macrophages (HMDM), as assessed by western blot and zymography experiments, respectively. We reported that IL-21 did not increase the production of IL-6 and the chemokines MIP-1α and GRO-α in HMDM. Therefore, IL-21 can increase functions other that phagocytosis, but this cytokine does not have a large spectrum of biological activities in monocytes and macrophages." @default.
• W2912704706 created "2019-02-21" @default.
• W2912704706 creator A5009082301 @default.
• W2912704706 creator A5013766392 @default.
• W2912704706 creator A5017952049 @default.
• W2912704706 date "2019-03-01" @default.
• W2912704706 modified "2023-10-16" @default.
• W2912704706 title "Biological activities of interleukin (IL)-21 in human monocytes and macrophages" @default.
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• W2912704706 doi "https://doi.org/10.1016/j.cellimm.2019.02.002" @default.
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