Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912708636> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2912708636 abstract "Human cytomegalovirus is the most common cause of congenital and perinatal infections throughout the world. Primary infection with human cytomegalovirus usually follows a benign course, but the virus remains latent or persistent in the host cell thereafter. Understanding the epidemiology of human cytomegalovirus is a key element in the development of strategies for prevention of infection. Although the actual sites of latency or persistence of human cytomegalovirus infections are still controversial, peripheral blood mononuclear cells and endothelial cells appear to be major sites of infection. Persistent infections caused by human cytomegalovirus could be augmented by a decrease in major histocompatibility complex expression as well as by virus-mediated immune dysfunction. It is possible that specific cellular interactions as well as production of several cytokines are necessary for the reactivation of human cytomegalovirus. Breast-fed infants are susceptible to human cytomegalovirus infection from breast milk. Human cytomegalovirus was isolated more frequently from breast milk at more than 1 month after delivery than from colostrum or early breast milk. Human cytomegalovirus DNA was also not detected in colostrum, but was found in breast milk samples 1 month after delivery. To clarify the role of milk cells and whey in vertical infection by breast feeding, we separated breast milk into milk cells and whey and examined each fraction. Human cytomegalovirus was isolated more frequently from milk whey samples than from cell samples. Human cytomegalovirus particle shedding into whey may be more important in vertical infection by breast milk than cell-to-cell transmission. The supernatant of colostrum did not exert an inhibitory effect on human cytomegalovirus-infected cells. Serum levels of cell free soluble interleukin-2 receptor of mothers with DNA-positive milk at 1 month after delivery were significantly higher than those of mothers with DNA-negative milk. It is likely that levels of factors such as soluble interleukin-2 receptor in serum are related to the reactivation of human cytomegalovirus which occurs locally in the mammary gland of the lactating mother after delivery. This minireview focuses on recent advances in the study of human cytomegalovirus infection of breast milk." @default.
- W2912708636 created "2019-02-21" @default.
- W2912708636 creator A5008283601 @default.
- W2912708636 date "1997-06-01" @default.
- W2912708636 modified "2023-09-25" @default.
- W2912708636 title "Human cytomegalovirus infection of breast milk" @default.
- W2912708636 doi "https://doi.org/10.1016/s0928-8244(97)00032-1" @default.
- W2912708636 hasPublicationYear "1997" @default.
- W2912708636 type Work @default.
- W2912708636 sameAs 2912708636 @default.
- W2912708636 citedByCount "0" @default.
- W2912708636 crossrefType "journal-article" @default.
- W2912708636 hasAuthorship W2912708636A5008283601 @default.
- W2912708636 hasBestOaLocation W29127086361 @default.
- W2912708636 hasConcept C159047783 @default.
- W2912708636 hasConcept C159654299 @default.
- W2912708636 hasConcept C187212893 @default.
- W2912708636 hasConcept C203014093 @default.
- W2912708636 hasConcept C2522874641 @default.
- W2912708636 hasConcept C2775871700 @default.
- W2912708636 hasConcept C2776409557 @default.
- W2912708636 hasConcept C2777662283 @default.
- W2912708636 hasConcept C2777732132 @default.
- W2912708636 hasConcept C2779073587 @default.
- W2912708636 hasConcept C2779820661 @default.
- W2912708636 hasConcept C2780727368 @default.
- W2912708636 hasConcept C3020294031 @default.
- W2912708636 hasConcept C55493867 @default.
- W2912708636 hasConcept C71924100 @default.
- W2912708636 hasConcept C86803240 @default.
- W2912708636 hasConcept C8891405 @default.
- W2912708636 hasConceptScore W2912708636C159047783 @default.
- W2912708636 hasConceptScore W2912708636C159654299 @default.
- W2912708636 hasConceptScore W2912708636C187212893 @default.
- W2912708636 hasConceptScore W2912708636C203014093 @default.
- W2912708636 hasConceptScore W2912708636C2522874641 @default.
- W2912708636 hasConceptScore W2912708636C2775871700 @default.
- W2912708636 hasConceptScore W2912708636C2776409557 @default.
- W2912708636 hasConceptScore W2912708636C2777662283 @default.
- W2912708636 hasConceptScore W2912708636C2777732132 @default.
- W2912708636 hasConceptScore W2912708636C2779073587 @default.
- W2912708636 hasConceptScore W2912708636C2779820661 @default.
- W2912708636 hasConceptScore W2912708636C2780727368 @default.
- W2912708636 hasConceptScore W2912708636C3020294031 @default.
- W2912708636 hasConceptScore W2912708636C55493867 @default.
- W2912708636 hasConceptScore W2912708636C71924100 @default.
- W2912708636 hasConceptScore W2912708636C86803240 @default.
- W2912708636 hasConceptScore W2912708636C8891405 @default.
- W2912708636 hasLocation W29127086361 @default.
- W2912708636 hasOpenAccess W2912708636 @default.
- W2912708636 hasPrimaryLocation W29127086361 @default.
- W2912708636 hasRelatedWork W1519236541 @default.
- W2912708636 hasRelatedWork W1519836751 @default.
- W2912708636 hasRelatedWork W15568090 @default.
- W2912708636 hasRelatedWork W15792046 @default.
- W2912708636 hasRelatedWork W1633380118 @default.
- W2912708636 hasRelatedWork W1847851848 @default.
- W2912708636 hasRelatedWork W1989828957 @default.
- W2912708636 hasRelatedWork W1990498751 @default.
- W2912708636 hasRelatedWork W2001848753 @default.
- W2912708636 hasRelatedWork W2074847142 @default.
- W2912708636 hasRelatedWork W2075845574 @default.
- W2912708636 hasRelatedWork W2094056567 @default.
- W2912708636 hasRelatedWork W2094506304 @default.
- W2912708636 hasRelatedWork W2130920604 @default.
- W2912708636 hasRelatedWork W2142089580 @default.
- W2912708636 hasRelatedWork W2150933195 @default.
- W2912708636 hasRelatedWork W2221749821 @default.
- W2912708636 hasRelatedWork W2280960171 @default.
- W2912708636 hasRelatedWork W2562505728 @default.
- W2912708636 hasRelatedWork W3020297565 @default.
- W2912708636 isParatext "false" @default.
- W2912708636 isRetracted "false" @default.
- W2912708636 magId "2912708636" @default.
- W2912708636 workType "article" @default.