Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912709109> ?p ?o ?g. }
- W2912709109 endingPage "44" @default.
- W2912709109 startingPage "34" @default.
- W2912709109 abstract "The addition of temozolomide (TMZ) to radiotherapy (RT) improves survival of patients with glioblastoma (GBM). However, TMZ + RT causes excess toxicity in patients. In this study, we prepared angiopep-2 (A2) modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles for TMZ delivery (A2-P(MIs)25/TMZ) to achieve synergistic effects against glioma. This A2-P(MIs)25/TMZ display highly promising advantages: (1) a hydrophobic P-(MIs)25 core where poorly water-soluble TMZ can be encapsulated; (2) nitro groups of the hydrophobic P-(MIs)25 core that are converted into hydrophilic amino groups (P(NH2s)25) under low oxygen conditions to mimic the oxygen-increased sensitization to RT; (3) a lipid monolayer at the interface of the core and the shell to modify the A2 (a specific ligand for low-density lipoprotein receptor-related protein-1 (LRP-1), which are expressed in the blood-brain barrier (BBB) and human glioma cells), thereby enhancing the drug encapsulation efficiency in glioma. These nanoparticles appear as a promising and robust nanoplatforms for TMZ and hypoxic cell radiosensitization delivery." @default.
- W2912709109 created "2019-02-21" @default.
- W2912709109 creator A5000838361 @default.
- W2912709109 creator A5001696156 @default.
- W2912709109 creator A5002442029 @default.
- W2912709109 creator A5002656825 @default.
- W2912709109 creator A5026230096 @default.
- W2912709109 creator A5041406433 @default.
- W2912709109 creator A5047498651 @default.
- W2912709109 creator A5053942013 @default.
- W2912709109 creator A5063749738 @default.
- W2912709109 creator A5066752156 @default.
- W2912709109 creator A5078144379 @default.
- W2912709109 date "2019-01-01" @default.
- W2912709109 modified "2023-10-10" @default.
- W2912709109 title "Self-assembled angiopep-2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ for glioma synergistic TMZ and RT therapy" @default.
- W2912709109 cites W1971292623 @default.
- W2912709109 cites W1974210709 @default.
- W2912709109 cites W1988029997 @default.
- W2912709109 cites W1990310575 @default.
- W2912709109 cites W1994209506 @default.
- W2912709109 cites W2006999776 @default.
- W2912709109 cites W2010976109 @default.
- W2912709109 cites W2013994232 @default.
- W2912709109 cites W2015268376 @default.
- W2912709109 cites W2023776747 @default.
- W2912709109 cites W2028579131 @default.
- W2912709109 cites W2032342631 @default.
- W2912709109 cites W2032371417 @default.
- W2912709109 cites W2051193631 @default.
- W2912709109 cites W2051523419 @default.
- W2912709109 cites W2054210405 @default.
- W2912709109 cites W2054333460 @default.
- W2912709109 cites W2082015870 @default.
- W2912709109 cites W2094900768 @default.
- W2912709109 cites W2096287682 @default.
- W2912709109 cites W2102607558 @default.
- W2912709109 cites W2115034438 @default.
- W2912709109 cites W2121205576 @default.
- W2912709109 cites W2123053149 @default.
- W2912709109 cites W2152558985 @default.
- W2912709109 cites W2164534132 @default.
- W2912709109 cites W2169414079 @default.
- W2912709109 cites W2172819759 @default.
- W2912709109 cites W2197203468 @default.
- W2912709109 cites W2319463151 @default.
- W2912709109 cites W2321905436 @default.
- W2912709109 cites W2412902998 @default.
- W2912709109 cites W2415430178 @default.
- W2912709109 cites W2416932183 @default.
- W2912709109 cites W2462808684 @default.
- W2912709109 cites W2464824758 @default.
- W2912709109 cites W2587758675 @default.
- W2912709109 cites W2768364813 @default.
- W2912709109 cites W92501227 @default.
- W2912709109 doi "https://doi.org/10.1080/10717544.2018.1534897" @default.
- W2912709109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6394306" @default.
- W2912709109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30744436" @default.
- W2912709109 hasPublicationYear "2019" @default.
- W2912709109 type Work @default.
- W2912709109 sameAs 2912709109 @default.
- W2912709109 citedByCount "26" @default.
- W2912709109 countsByYear W29127091092019 @default.
- W2912709109 countsByYear W29127091092020 @default.
- W2912709109 countsByYear W29127091092021 @default.
- W2912709109 countsByYear W29127091092022 @default.
- W2912709109 countsByYear W29127091092023 @default.
- W2912709109 crossrefType "journal-article" @default.
- W2912709109 hasAuthorship W2912709109A5000838361 @default.
- W2912709109 hasAuthorship W2912709109A5001696156 @default.
- W2912709109 hasAuthorship W2912709109A5002442029 @default.
- W2912709109 hasAuthorship W2912709109A5002656825 @default.
- W2912709109 hasAuthorship W2912709109A5026230096 @default.
- W2912709109 hasAuthorship W2912709109A5041406433 @default.
- W2912709109 hasAuthorship W2912709109A5047498651 @default.
- W2912709109 hasAuthorship W2912709109A5053942013 @default.
- W2912709109 hasAuthorship W2912709109A5063749738 @default.
- W2912709109 hasAuthorship W2912709109A5066752156 @default.
- W2912709109 hasAuthorship W2912709109A5078144379 @default.
- W2912709109 hasBestOaLocation W29127091091 @default.
- W2912709109 hasConcept C12554922 @default.
- W2912709109 hasConcept C171250308 @default.
- W2912709109 hasConcept C185592680 @default.
- W2912709109 hasConcept C192562407 @default.
- W2912709109 hasConcept C203014093 @default.
- W2912709109 hasConcept C2776217527 @default.
- W2912709109 hasConcept C2777389519 @default.
- W2912709109 hasConcept C2778227246 @default.
- W2912709109 hasConcept C2779820397 @default.
- W2912709109 hasConcept C502942594 @default.
- W2912709109 hasConcept C71924100 @default.
- W2912709109 hasConcept C86803240 @default.
- W2912709109 hasConcept C98274493 @default.
- W2912709109 hasConceptScore W2912709109C12554922 @default.
- W2912709109 hasConceptScore W2912709109C171250308 @default.
- W2912709109 hasConceptScore W2912709109C185592680 @default.
- W2912709109 hasConceptScore W2912709109C192562407 @default.
- W2912709109 hasConceptScore W2912709109C203014093 @default.