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- W2912709124 endingPage "65" @default.
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- W2912709124 abstract "Lipopeptide antibiotics have linear or cyclic structures with one or more hydrocarbon tails linked to the N-terminus of a short oligopeptide that may be chemically modified and/or contain unusual amino acid residues in their structures. They possess huge potential as pharmaceutical drugs and biocontrol agents, and ˜30 representative genera of fungi are known to produce them. Some chemically synthesised derivatives have already been developed into commercial products or subjected to clinical trials, including cilofungin, caspofungin, micafungin, anidulafungin, rezafungin, emodepside, fusafungine and destruxins. This review summarizes 200 fungi-derived compounds reported since 2000, including 95 cyclic depsipeptides, 67 peptaibiotics (including 35 peptaibols, eight lipoaminopeptides, and five lipopeptaibols), and 38 non-depsipeptide and non-peptaibiotic lipopeptides. Their sources, structural sequences, antibiotic activities (e.g. antibacterial, antifungal, antiviral, antimycobacterial, antimycoplasmal, antimalarial, antileishmanial, insecticidal, antitrypanosomal and nematicidal), structure-activity relationships, mechanisms of action, and specific relevance are discussed. These compounds have attracted considerable interest within the pharmaceutical and agrochemical industries." @default.
- W2912709124 created "2019-02-21" @default.
- W2912709124 creator A5000758682 @default.
- W2912709124 creator A5022526821 @default.
- W2912709124 creator A5025564615 @default.
- W2912709124 creator A5039088827 @default.
- W2912709124 creator A5040664570 @default.
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- W2912709124 creator A5058127775 @default.
- W2912709124 creator A5060890822 @default.
- W2912709124 creator A5073551888 @default.
- W2912709124 date "2019-03-01" @default.
- W2912709124 modified "2023-10-15" @default.
- W2912709124 title "Fungi-derived lipopeptide antibiotics developed since 2000" @default.
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