FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912709598> ?p ?o ?g. }

• W2912709598 endingPage "249" @default.
• W2912709598 startingPage "246" @default.
• W2912709598 abstract "<b><i>Background/Aims:</i></b> Administration of tablets via feeding tube (FT) is often associated with significant drug losses, as was confirmed by weighing. The aim of this study was to measure the proportion of active substance losses (ASLs) in an in vitro model. <b><i>Methods:</i></b> A film-coated tablet (FilmCT) containing clopidogrel (Trombex®) and a tablet with enteric coating (EntericCT) containing pantoprazole (Controloc®) were crushed in a mortar and transferred by method A (tablet powder was transferred into the beaker, poured into the syringe and water added) and method B (water was added into the mortar, suspension drawn into the syringe) and administered via FT in an in vitro model. Total losses were measured with analytical balance and, simultaneously, ASL were analyzed with high-performance liquid chromatography UV-detection (HPLC-UV). <b><i>Results:</i></b> ASL was different to weighing only in the case of EntericCT prepared by method B (2.0 ± 4.2 and 10.7 ± 0.8% for HPLC-UV and weighing, respectively; <i>p</i> = 0.004). HPLC-UV confirmed significantly lower ASL when method B was used for either EntericCT (34.3 ± 7.2 vs. 2.0 ± 4.2%; <i>p</i> &#x3c; 0.001) or FilmCT (14.1 ± 2.2 vs. 7.7 ± 4.1%; <i>p</i> &#x3c; 0.01). <b><i>Conclusion:</i></b> Drug loss analysis with analytical balance may overestimate ASL, as was proved for EntericCT in this study. ASL were significantly lower when method B was used." @default.
• W2912709598 created "2019-02-21" @default.
• W2912709598 creator A5030625533 @default.
• W2912709598 creator A5038681999 @default.
• W2912709598 creator A5040652875 @default.
• W2912709598 creator A5071979119 @default.
• W2912709598 date "2019-01-01" @default.
• W2912709598 modified "2023-10-01" @default.
• W2912709598 title "Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube" @default.
• W2912709598 cites W2012029168 @default.
• W2912709598 cites W2013985830 @default.
• W2912709598 cites W2092504534 @default.
• W2912709598 cites W2093883134 @default.
• W2912709598 cites W2095806479 @default.
• W2912709598 cites W2156936581 @default.
• W2912709598 cites W2255972846 @default.
• W2912709598 cites W2789301021 @default.
• W2912709598 cites W1753508471 @default.
• W2912709598 doi "https://doi.org/10.1159/000496423" @default.
• W2912709598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30726848" @default.
• W2912709598 hasPublicationYear "2019" @default.
• W2912709598 type Work @default.
• W2912709598 sameAs 2912709598 @default.
• W2912709598 citedByCount "2" @default.
• W2912709598 countsByYear W29127095982022 @default.
• W2912709598 countsByYear W29127095982023 @default.
• W2912709598 crossrefType "journal-article" @default.
• W2912709598 hasAuthorship W2912709598A5030625533 @default.
• W2912709598 hasAuthorship W2912709598A5038681999 @default.
• W2912709598 hasAuthorship W2912709598A5040652875 @default.
• W2912709598 hasAuthorship W2912709598A5071979119 @default.
• W2912709598 hasConcept C118552586 @default.
• W2912709598 hasConcept C179998833 @default.
• W2912709598 hasConcept C185592680 @default.
• W2912709598 hasConcept C2778571141 @default.
• W2912709598 hasConcept C43617362 @default.
• W2912709598 hasConcept C71924100 @default.
• W2912709598 hasConceptScore W2912709598C118552586 @default.
• W2912709598 hasConceptScore W2912709598C179998833 @default.
• W2912709598 hasConceptScore W2912709598C185592680 @default.
• W2912709598 hasConceptScore W2912709598C2778571141 @default.
• W2912709598 hasConceptScore W2912709598C43617362 @default.
• W2912709598 hasConceptScore W2912709598C71924100 @default.
• W2912709598 hasIssue "5-6" @default.
• W2912709598 hasLocation W29127095981 @default.
• W2912709598 hasLocation W29127095982 @default.
• W2912709598 hasOpenAccess W2912709598 @default.
• W2912709598 hasPrimaryLocation W29127095981 @default.
• W2912709598 hasRelatedWork W2042795066 @default.
• W2912709598 hasRelatedWork W2055781229 @default.
• W2912709598 hasRelatedWork W2095306786 @default.
• W2912709598 hasRelatedWork W2114353500 @default.
• W2912709598 hasRelatedWork W2145213465 @default.
• W2912709598 hasRelatedWork W2189200885 @default.
• W2912709598 hasRelatedWork W2352674505 @default.
• W2912709598 hasRelatedWork W2360903818 @default.
• W2912709598 hasRelatedWork W2405302437 @default.
• W2912709598 hasRelatedWork W2417209194 @default.
• W2912709598 hasVolume "103" @default.
• W2912709598 isParatext "false" @default.
• W2912709598 isRetracted "false" @default.
• W2912709598 magId "2912709598" @default.
• W2912709598 workType "article" @default.