Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912721163> ?p ?o ?g. }
- W2912721163 abstract "Abstract More than 50% of colon cancers bear mutations in p53, one of the most important tumor suppressors, and its family members p63 or p73 are expected to contribute to inhibiting the progression of colon cancers. The AP2 family also acts as a tumor suppressor. Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans. Under serum starvation, NEU4 was up-regulated and one of the NEU4 target glycans, sialyl Lewis X, was decreased, whereas p73 and AP2 were up-regulated. Sialyl Lewis X levels were not, however, decreased under starvation conditions in p73- or AP2-knockdown cells. p53 and AP2 underwent protein-protein interactions, exerting synergistic effects to activate p21, and interaction of p53 with AP2 was lost in cells expressing the L350P mutation of p53. The homologous residues in p63 and p73 are L423 and L377, respectively. The synergistic effect of p53/p63 with AP2 to activate genes was lost with the L350P/L423P mutation in p53/p63, but p73 bearing the L377P mutation was able to interact with AP2 and exerted its normal synergistic effects. We propose that p73 and AP2 synergistically activate the NEU4 promoter in colon cancer cells." @default.
- W2912721163 created "2019-02-21" @default.
- W2912721163 creator A5006279268 @default.
- W2912721163 creator A5012160359 @default.
- W2912721163 creator A5016980011 @default.
- W2912721163 creator A5023210798 @default.
- W2912721163 creator A5027786827 @default.
- W2912721163 creator A5048691355 @default.
- W2912721163 creator A5050369271 @default.
- W2912721163 creator A5058955694 @default.
- W2912721163 creator A5078633700 @default.
- W2912721163 date "2019-01-30" @default.
- W2912721163 modified "2023-09-24" @default.
- W2912721163 title "Synergistic activation of the NEU4 promoter by p73 and AP2 in colon cancer cells" @default.
- W2912721163 cites W1182461782 @default.
- W2912721163 cites W1570578677 @default.
- W2912721163 cites W1576326989 @default.
- W2912721163 cites W1897432297 @default.
- W2912721163 cites W1937707692 @default.
- W2912721163 cites W1964405387 @default.
- W2912721163 cites W1964733653 @default.
- W2912721163 cites W1965233827 @default.
- W2912721163 cites W1971440525 @default.
- W2912721163 cites W1976437934 @default.
- W2912721163 cites W1978406914 @default.
- W2912721163 cites W1984253873 @default.
- W2912721163 cites W1989637780 @default.
- W2912721163 cites W1993207246 @default.
- W2912721163 cites W1997798522 @default.
- W2912721163 cites W1997936030 @default.
- W2912721163 cites W2001781880 @default.
- W2912721163 cites W2004740605 @default.
- W2912721163 cites W2005272275 @default.
- W2912721163 cites W2015519364 @default.
- W2912721163 cites W2020715178 @default.
- W2912721163 cites W2021109304 @default.
- W2912721163 cites W2036837184 @default.
- W2912721163 cites W2036957940 @default.
- W2912721163 cites W2037710041 @default.
- W2912721163 cites W2039553809 @default.
- W2912721163 cites W2049672603 @default.
- W2912721163 cites W2053847776 @default.
- W2912721163 cites W2054271640 @default.
- W2912721163 cites W2054549064 @default.
- W2912721163 cites W2058481603 @default.
- W2912721163 cites W2061658069 @default.
- W2912721163 cites W2066340159 @default.
- W2912721163 cites W2068533231 @default.
- W2912721163 cites W2072987445 @default.
- W2912721163 cites W2081217273 @default.
- W2912721163 cites W2088010622 @default.
- W2912721163 cites W2092073124 @default.
- W2912721163 cites W2094033944 @default.
- W2912721163 cites W2095732342 @default.
- W2912721163 cites W2114078657 @default.
- W2912721163 cites W2123629596 @default.
- W2912721163 cites W2124317124 @default.
- W2912721163 cites W2136683006 @default.
- W2912721163 cites W2136911663 @default.
- W2912721163 cites W2140686380 @default.
- W2912721163 cites W2144168458 @default.
- W2912721163 cites W2149214251 @default.
- W2912721163 cites W2150649688 @default.
- W2912721163 cites W2155072174 @default.
- W2912721163 cites W2162800127 @default.
- W2912721163 cites W2163184189 @default.
- W2912721163 cites W2169462450 @default.
- W2912721163 cites W2171523013 @default.
- W2912721163 cites W2321667820 @default.
- W2912721163 cites W2334988436 @default.
- W2912721163 cites W2508267943 @default.
- W2912721163 cites W2534292219 @default.
- W2912721163 cites W2591339934 @default.
- W2912721163 cites W2607129810 @default.
- W2912721163 cites W2619529151 @default.
- W2912721163 doi "https://doi.org/10.1038/s41598-018-37521-7" @default.
- W2912721163 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6353964" @default.
- W2912721163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30700826" @default.
- W2912721163 hasPublicationYear "2019" @default.
- W2912721163 type Work @default.
- W2912721163 sameAs 2912721163 @default.
- W2912721163 citedByCount "10" @default.
- W2912721163 countsByYear W29127211632019 @default.
- W2912721163 countsByYear W29127211632021 @default.
- W2912721163 countsByYear W29127211632022 @default.
- W2912721163 countsByYear W29127211632023 @default.
- W2912721163 crossrefType "journal-article" @default.
- W2912721163 hasAuthorship W2912721163A5006279268 @default.
- W2912721163 hasAuthorship W2912721163A5012160359 @default.
- W2912721163 hasAuthorship W2912721163A5016980011 @default.
- W2912721163 hasAuthorship W2912721163A5023210798 @default.
- W2912721163 hasAuthorship W2912721163A5027786827 @default.
- W2912721163 hasAuthorship W2912721163A5048691355 @default.
- W2912721163 hasAuthorship W2912721163A5050369271 @default.
- W2912721163 hasAuthorship W2912721163A5058955694 @default.
- W2912721163 hasAuthorship W2912721163A5078633700 @default.
- W2912721163 hasBestOaLocation W29127211631 @default.
- W2912721163 hasConcept C104317684 @default.
- W2912721163 hasConcept C134164806 @default.
- W2912721163 hasConcept C153911025 @default.