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- W2912721609 endingPage "301" @default.
- W2912721609 startingPage "289" @default.
- W2912721609 abstract "Over the last few decades, advances in human and animal-based techniques have greatly enhanced our understanding of the neural mechanisms underlying psychiatric disorders. Many of these studies have indicated connectivity between and alterations within basal ganglia structures to be particularly pertinent to the development of symptoms associated with several of these disorders. Here we summarize the connectivity, molecular composition, and function of sites within basal ganglia neurocircuits. Then we review the current literature from both human and animal studies concerning altered basal ganglia function in five common psychiatric disorders: obsessive–compulsive disorder, substance-related and addiction disorders, major depressive disorder, generalized anxiety disorder, and schizophrenia. Finally, we present a model based upon the findings of these studies that highlights the striatum as a particularly attractive target for restoring normal function to basal ganglia neurocircuits altered within psychiatric disorder patients." @default.
- W2912721609 created "2019-02-21" @default.
- W2912721609 creator A5030950258 @default.
- W2912721609 creator A5032274523 @default.
- W2912721609 date "2019-03-05" @default.
- W2912721609 modified "2023-10-11" @default.
- W2912721609 title "Role of basal ganglia neurocircuitry in the pathology of psychiatric disorders" @default.
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