FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912721619> ?p ?o ?g. }

• W2912721619 endingPage "157" @default.
• W2912721619 startingPage "148" @default.
• W2912721619 abstract "Higher aspirin doses may be inferior in ticagrelor-treated acute coronary syndrome (ACS) patients and reducing bleeding risk whilst maintaining antithrombotic benefits could improve outcomes. We characterized the pharmacodynamics of a novel dual-antiplatelet-therapy regimen consisting of very-low-dose twice-daily (BD) aspirin with standard-dose ticagrelor. A total of 20 ticagrelor-treated ACS patients entered a randomized crossover to take aspirin 20 mg BD (12-hourly) during one 14-day period and 75 mg once-daily (OD) in the other. After 14 days of treatment, serum thromboxane (TX)B2 and light-transmittance aggregometry were assessed pre- and 2 h post-morning-dose, bleeding time was measured post-dose, and TXA2 and prostacyclin stable metabolites were measured in urine collected 2 h post-morning-dose. Data are expressed as mean ± SD. After 14 days treatment, serum TXB2 levels were significantly greater 2 h post-dosing with aspirin 20 mg BD vs. 75 mg OD (3.0 ± 3.6 ng/mL vs. 0.8 ± 1.9 ng/mL; p = 0.018) whereas pre-dosing levels were not significantly different (3.5 ± 4.1 ng/mL vs. 2.5 ± 3.1 ng/mL, p = 0.23). 1-mmol/L arachidonic acid-induced platelet aggregation was similarly inhibited by both regimens pre-dose (8.5 ± 14.3% vs. 5.1 ± 3.6%, p = 0.24) and post-dose (8.7 ± 14.2% vs. 6.6 ± 5.3%; p = 0.41). Post-dose bleeding time was shorter with 20 mg BD (680 ± 306 s vs. 834 ± 386 s, p = 0.02). Urinary prostacyclin and TX metabolite excretion were not significantly different. In conclusion, compared to aspirin 75 mg OD, aspirin 20 mg BD provided consistent inhibition of platelet TXA2 release and aggregation, and improved post-dose hemostasis, in ticagrelor-treated ACS patients. Further studies are warranted to assess whether this regimen improves the balance of clinical efficacy and safety." @default.
• W2912721619 created "2019-02-21" @default.
• W2912721619 creator A5005951482 @default.
• W2912721619 creator A5030753605 @default.
• W2912721619 creator A5039450208 @default.
• W2912721619 creator A5051638272 @default.
• W2912721619 creator A5052806409 @default.
• W2912721619 creator A5057207523 @default.
• W2912721619 creator A5057738047 @default.
• W2912721619 creator A5058841781 @default.
• W2912721619 creator A5060595885 @default.
• W2912721619 creator A5065624650 @default.
• W2912721619 creator A5079782260 @default.
• W2912721619 creator A5081639011 @default.
• W2912721619 creator A5086223086 @default.
• W2912721619 creator A5089522365 @default.
• W2912721619 date "2019-02-13" @default.
• W2912721619 modified "2023-10-01" @default.
• W2912721619 title "Very-low-dose twice-daily aspirin maintains platelet inhibition and improves haemostasis during dual-antiplatelet therapy for acute coronary syndrome" @default.
• W2912721619 cites W10734288 @default.
• W2912721619 cites W1582447064 @default.
• W2912721619 cites W1630039729 @default.
• W2912721619 cites W1888992399 @default.
• W2912721619 cites W1915082808 @default.
• W2912721619 cites W1933244338 @default.
• W2912721619 cites W1969497394 @default.
• W2912721619 cites W198723458 @default.
• W2912721619 cites W1987873498 @default.
• W2912721619 cites W2000402404 @default.
• W2912721619 cites W2009461799 @default.
• W2912721619 cites W2014644245 @default.
• W2912721619 cites W2015013806 @default.
• W2912721619 cites W2015175766 @default.
• W2912721619 cites W2017299352 @default.
• W2912721619 cites W2036378379 @default.
• W2912721619 cites W2047223997 @default.
• W2912721619 cites W2054008451 @default.
• W2912721619 cites W2054036069 @default.
• W2912721619 cites W2063088168 @default.
• W2912721619 cites W2067547166 @default.
• W2912721619 cites W2073836848 @default.
• W2912721619 cites W2085260510 @default.
• W2912721619 cites W2086100979 @default.
• W2912721619 cites W2087108627 @default.
• W2912721619 cites W2087724955 @default.
• W2912721619 cites W2092011140 @default.
• W2912721619 cites W2100858861 @default.
• W2912721619 cites W2105397247 @default.
• W2912721619 cites W2105735830 @default.
• W2912721619 cites W2105820736 @default.
• W2912721619 cites W2112053196 @default.
• W2912721619 cites W2112380741 @default.
• W2912721619 cites W2115824015 @default.
• W2912721619 cites W2125389594 @default.
• W2912721619 cites W2135393211 @default.
• W2912721619 cites W2137265742 @default.
• W2912721619 cites W2140501627 @default.
• W2912721619 cites W2141358924 @default.
• W2912721619 cites W2149011208 @default.
• W2912721619 cites W2161844490 @default.
• W2912721619 cites W2166950143 @default.
• W2912721619 cites W2182042869 @default.
• W2912721619 cites W2266462757 @default.
• W2912721619 cites W2298958687 @default.
• W2912721619 cites W2412782592 @default.
• W2912721619 cites W2430015321 @default.
• W2912721619 cites W2431546415 @default.
• W2912721619 cites W2528981159 @default.
• W2912721619 cites W2576421000 @default.
• W2912721619 cites W2591898919 @default.
• W2912721619 cites W2604835455 @default.
• W2912721619 cites W2609974386 @default.
• W2912721619 cites W2613818341 @default.
• W2912721619 cites W2789512318 @default.
• W2912721619 cites W2789805921 @default.
• W2912721619 cites W2790804384 @default.
• W2912721619 cites W2805991204 @default.
• W2912721619 cites W2809722890 @default.
• W2912721619 cites W2888458270 @default.
• W2912721619 cites W4236531408 @default.
• W2912721619 cites W4293372203 @default.
• W2912721619 cites W49756499 @default.
• W2912721619 cites W63425872 @default.
• W2912721619 cites W80146237 @default.
• W2912721619 doi "https://doi.org/10.1080/09537104.2019.1572880" @default.
• W2912721619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6425913" @default.
• W2912721619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30759035" @default.
• W2912721619 hasPublicationYear "2019" @default.
• W2912721619 type Work @default.
• W2912721619 sameAs 2912721619 @default.
• W2912721619 citedByCount "23" @default.
• W2912721619 countsByYear W29127216192019 @default.
• W2912721619 countsByYear W29127216192020 @default.
• W2912721619 countsByYear W29127216192021 @default.
• W2912721619 countsByYear W29127216192022 @default.
• W2912721619 countsByYear W29127216192023 @default.
• W2912721619 crossrefType "journal-article" @default.
• W2912721619 hasAuthorship W2912721619A5005951482 @default.

• next