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• W2912722043 abstract "<b><i>Background:</i></b> We aimed to determine the promoter methylation status of the retinoic acid receptor-beta 2 <i>(RARβ2)</i> gene among breast cancer patients and to review relevant studies in this field in various populations. <b><i>Methods:</i></b> We analyzed 400 samples which comprised blood specimens from 102 breast cancer patients, 102 first-degree female relatives of patients, 100 cancer-free females, 48 breast cancer tissues, and 48 adjacent normal breast tissues from the same patients. The <i>RARβ2</i> methylation status was determined using methylation-specific polymerase chain reaction (MSP) and DNA sequencing methods. <b><i>Results:</i></b> The presence of combined partially methylated (MU) and fully methylated (MM) forms of the <i>RARβ2 </i>gene (MU+MM) in the blood of patients was associated with susceptibility to breast cancer (odds ratio = 4.7, p = 0.05). A significantly higher frequency of the MM genotype was observed in cancer tissue (10.4%) compared to matched adjacent normal breast tissue (0%) (p = 0.02). <b><i>Conclusion:</i></b> We found a higher frequency of <i>RARβ2</i> gene methylation in the blood and cancer tissues of patients compared to the blood of controls and adjacent normal breast tissues. The survey of studies on various populations demonstrated a higher <i>RARβ2</i> methylation frequency in breast cancer patients compared to normal individuals, and many reports suggest a significant association between hypermethylation of the gene and susceptibility to breast cancer." @default.
• W2912722043 created "2019-02-21" @default.
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• W2912722043 date "2019-01-01" @default.
• W2912722043 modified "2023-09-25" @default.
• W2912722043 title "Promoter Methylation Status of the Retinoic Acid Receptor-Beta 2 Gene in Breast Cancer Patients: A Case Control Study and Systematic Review" @default.
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• W2912722043 doi "https://doi.org/10.1159/000489874" @default.
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