Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912732489> ?p ?o ?g. }
- W2912732489 endingPage "1019" @default.
- W2912732489 startingPage "1008" @default.
- W2912732489 abstract "The Arf and Rab/Ypt GTPases coordinately regulate membrane traffic and organelle structure by regulating vesicle formation and fusion. Ample evidence has indicated that proteins in these two families may function in parallel or complementarily; however, the manner in which Arf and Rab/Ypt proteins perform interchangeable functions remains unclear. In this study, we report that a Golgi-localized Arf, Arl1, could suppress Ypt6 dysfunction via its effector golgin, Imh1, but not via the lipid flippase Drs2. Ypt6 is critical for the retrograde transport of vesicles from endosomes to the trans-Golgi network (TGN), and its mutation leads to severe protein mislocalization and growth defects. We first overexpress the components of the Arl3-Syt1-Arl1-Imh1 cascade and show that only Arl1 and Imh1 can restore endosome-to-TGN trafficking in ypt6-deleted cells. Interestingly, increased abundance of Arl1 or Imh1 restores localization of the tethering factor Golgi associated retrograde-protein (GARP) complex to the TGN in the absence of Ypt6. We further show that the N-terminal domain of Imh1 is critical for restoring GARP localization and endosome-to-TGN transport in ypt6-deleted cells. Together, our results reveal the mechanism by which Arl1-Imh1 facilitates the recruitment of GARP to the TGN and compensates for the endosome-to-TGN trafficking defects in dysfunctional Ypt6 conditions." @default.
- W2912732489 created "2019-02-21" @default.
- W2912732489 creator A5039779230 @default.
- W2912732489 creator A5056918851 @default.
- W2912732489 creator A5063107004 @default.
- W2912732489 creator A5065493569 @default.
- W2912732489 creator A5066372311 @default.
- W2912732489 creator A5083124768 @default.
- W2912732489 creator A5089925510 @default.
- W2912732489 date "2019-04-01" @default.
- W2912732489 modified "2023-10-17" @default.
- W2912732489 title "Action of Arl1 GTPase and golgin Imh1 in Ypt6-independent retrograde transport from endosomes to the<i>trans</i>-Golgi network" @default.
- W2912732489 cites W1604338879 @default.
- W2912732489 cites W1749731407 @default.
- W2912732489 cites W1964252660 @default.
- W2912732489 cites W1973749261 @default.
- W2912732489 cites W1977246577 @default.
- W2912732489 cites W1979184120 @default.
- W2912732489 cites W1982064876 @default.
- W2912732489 cites W1984356297 @default.
- W2912732489 cites W2006237582 @default.
- W2912732489 cites W2010728666 @default.
- W2912732489 cites W2012243695 @default.
- W2912732489 cites W2022598996 @default.
- W2912732489 cites W2031413882 @default.
- W2912732489 cites W2038454505 @default.
- W2912732489 cites W2053068636 @default.
- W2912732489 cites W2061539000 @default.
- W2912732489 cites W2062262275 @default.
- W2912732489 cites W2063028204 @default.
- W2912732489 cites W2068358300 @default.
- W2912732489 cites W2070194181 @default.
- W2912732489 cites W2073795777 @default.
- W2912732489 cites W2084055018 @default.
- W2912732489 cites W2091205354 @default.
- W2912732489 cites W2093678150 @default.
- W2912732489 cites W2101762911 @default.
- W2912732489 cites W2102226328 @default.
- W2912732489 cites W2103111390 @default.
- W2912732489 cites W2104813756 @default.
- W2912732489 cites W2107180729 @default.
- W2912732489 cites W2109910885 @default.
- W2912732489 cites W2111612340 @default.
- W2912732489 cites W2124733101 @default.
- W2912732489 cites W2127432085 @default.
- W2912732489 cites W2135465645 @default.
- W2912732489 cites W2135913937 @default.
- W2912732489 cites W2140660208 @default.
- W2912732489 cites W2140781391 @default.
- W2912732489 cites W2145159828 @default.
- W2912732489 cites W2146079593 @default.
- W2912732489 cites W2147016813 @default.
- W2912732489 cites W2148994860 @default.
- W2912732489 cites W2151663962 @default.
- W2912732489 cites W2154426762 @default.
- W2912732489 cites W2155644389 @default.
- W2912732489 cites W2156705968 @default.
- W2912732489 cites W2159460045 @default.
- W2912732489 cites W2159777821 @default.
- W2912732489 cites W2159843549 @default.
- W2912732489 cites W2161438543 @default.
- W2912732489 cites W2165332569 @default.
- W2912732489 cites W2168993487 @default.
- W2912732489 cites W2236604409 @default.
- W2912732489 cites W2272816145 @default.
- W2912732489 cites W2278160925 @default.
- W2912732489 cites W2293902722 @default.
- W2912732489 cites W2501745096 @default.
- W2912732489 cites W2582304668 @default.
- W2912732489 cites W2641920021 @default.
- W2912732489 cites W2766795802 @default.
- W2912732489 cites W2887750625 @default.
- W2912732489 cites W2901492518 @default.
- W2912732489 doi "https://doi.org/10.1091/mbc.e18-09-0579" @default.
- W2912732489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6589904" @default.
- W2912732489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30726160" @default.
- W2912732489 hasPublicationYear "2019" @default.
- W2912732489 type Work @default.
- W2912732489 sameAs 2912732489 @default.
- W2912732489 citedByCount "8" @default.
- W2912732489 countsByYear W29127324892019 @default.
- W2912732489 countsByYear W29127324892020 @default.
- W2912732489 countsByYear W29127324892022 @default.
- W2912732489 countsByYear W29127324892023 @default.
- W2912732489 crossrefType "journal-article" @default.
- W2912732489 hasAuthorship W2912732489A5039779230 @default.
- W2912732489 hasAuthorship W2912732489A5056918851 @default.
- W2912732489 hasAuthorship W2912732489A5063107004 @default.
- W2912732489 hasAuthorship W2912732489A5065493569 @default.
- W2912732489 hasAuthorship W2912732489A5066372311 @default.
- W2912732489 hasAuthorship W2912732489A5083124768 @default.
- W2912732489 hasAuthorship W2912732489A5089925510 @default.
- W2912732489 hasBestOaLocation W29127324891 @default.
- W2912732489 hasConcept C102747710 @default.
- W2912732489 hasConcept C119062480 @default.
- W2912732489 hasConcept C124682485 @default.
- W2912732489 hasConcept C130316041 @default.
- W2912732489 hasConcept C145458877 @default.