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- W2912734199 abstract "### Key learning pointsSubclinical hypothyroidism (SCH) is defined as an elevated thyroid-stimulating hormone (TSH) concentration in combination with normal concentration of free thyroxine (T4). Systematic review and meta-analysis shows that thyroxine replacement in non-pregnant adults with SCH confers no benefit in either thyroid-related symptoms or quality of life.In pregnancy, the definition of SCH requires gestation-specific reference intervals for TSH and T4, or a TSH between 4.0 and 10.0mU/L. SCH is estimated to affect 3%–5% of pregnant women. While overt hypothyroidism is recognised to be detrimental to pregnancy and treatment beneficial to pregnancy outcome and childhood development, it remains uncertain whether risk and the treatment benefit extend into the subclinical spectrum. This article considers the impact of pregnancy on the thyroid gland and thyroid function tests. Reference intervals for thyroid function are outlined including the new upper limit for TSH defined by the American Thyroid Association in 2017. Pregnancy outcomes in SCH are discussed and the evidence for thyroxine replacement is detailed.The endocrine and haemodynamic changes of pregnancy mean that it is often viewed as a physiological ‘stress test’ for different organ systems. This is apparent in the thyroid where the net effect …" @default.
- W2912734199 created "2019-02-21" @default.
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- W2912734199 date "2019-02-01" @default.
- W2912734199 modified "2023-09-25" @default.
- W2912734199 title "Management for women with subclinical hypothyroidism in pregnancy" @default.
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- W2912734199 doi "https://doi.org/10.1136/dtb.2018.000010" @default.
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