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- W2912741252 abstract "Immunotherapy with chimeric antigen receptor (CAR) T cells offers a promising method to improve cure rates and decrease morbidities for patients with cancer. In this regard, CD19-specific CAR T cell therapies have achieved dramatic objective responses for a high percent of patients with CD19-positive leukemia or lymphoma. Most patients with solid tumors however, have experienced transient or no benefit from CAR T cell therapies. Novel strategies are therefore needed to improve CAR T cell function for patients with solid tumors. One obstacle for the field is limited CAR T cell persistence after infusion into patients. In this review we highlight genetic engineering strategies to improve CAR T cell persistence for enhancing antitumor activity for patients with solid tumors." @default.
- W2912741252 created "2019-02-21" @default.
- W2912741252 creator A5036600955 @default.
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- W2912741252 date "2019-02-15" @default.
- W2912741252 modified "2023-10-16" @default.
- W2912741252 title "Genetic Modification Strategies to Enhance CAR T Cell Persistence for Patients With Solid Tumors" @default.
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- W2912741252 doi "https://doi.org/10.3389/fimmu.2019.00218" @default.
- W2912741252 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6384227" @default.
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