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- W2912746728 abstract "Abstract MTF1 is a conserved metal-binding transcription factor in eukaryotes that binds to conserved DNA sequence motifs, termed metal response elements (MREs). MTF1 responds to metal excess and deprivation, protects cells from oxidative and hypoxic stresses, and is required for embryonic development in vertebrates. We used multiple strategies to identify an unappreciated role for MTF1 and copper (Cu) in cell differentiation. Upon initiation of myogenesis from primary myoblasts, MTF1 expression increased, as did nuclear localization. Mtf1 knockdown impaired differentiation, while addition of non-toxic concentrations of Cu + enhanced MTF1 expression and promoted myogenesis. Cu + bound stoichiometrically to a C-terminus tetra-cysteine of MTF1. MTF1 bound to chromatin at the promoter regions of myogenic genes and binding was stimulated by copper. MTF1 formed a complex with MyoD at myogenic promoters, the master transcriptional regulator of the myogenic lineage. These studies establish novel mechanisms by which copper and MTF1 regulate gene expression in myoblast differentiation." @default.
- W2912746728 created "2019-02-21" @default.
- W2912746728 creator A5001549164 @default.
- W2912746728 creator A5007662444 @default.
- W2912746728 creator A5012275086 @default.
- W2912746728 creator A5022788997 @default.
- W2912746728 creator A5035770418 @default.
- W2912746728 creator A5039313284 @default.
- W2912746728 creator A5039916479 @default.
- W2912746728 creator A5067035449 @default.
- W2912746728 creator A5085682669 @default.
- W2912746728 creator A5088480659 @default.
- W2912746728 date "2019-01-29" @default.
- W2912746728 modified "2023-10-02" @default.
- W2912746728 title "MTF1, a classic metal sensing transcription factor, promotes myogenesis in response to copper" @default.
- W2912746728 cites W1547610032 @default.
- W2912746728 cites W1604713610 @default.
- W2912746728 cites W1628748664 @default.
- W2912746728 cites W175967323 @default.
- W2912746728 cites W1914010951 @default.
- W2912746728 cites W1955702721 @default.
- W2912746728 cites W1966676932 @default.
- W2912746728 cites W1967969993 @default.
- W2912746728 cites W1968628037 @default.
- W2912746728 cites W1969655939 @default.
- W2912746728 cites W1971314280 @default.
- W2912746728 cites W1972822540 @default.
- W2912746728 cites W1973260880 @default.
- W2912746728 cites W1973487146 @default.
- W2912746728 cites W1974543599 @default.
- W2912746728 cites W1976526711 @default.
- W2912746728 cites W1978579998 @default.
- W2912746728 cites W1984782455 @default.
- W2912746728 cites W1985061074 @default.
- W2912746728 cites W1985607497 @default.
- W2912746728 cites W1986291674 @default.
- W2912746728 cites W1986451029 @default.
- W2912746728 cites W1987211943 @default.
- W2912746728 cites W1989367110 @default.
- W2912746728 cites W1992256486 @default.
- W2912746728 cites W1992444784 @default.
- W2912746728 cites W1993168796 @default.
- W2912746728 cites W1994677299 @default.
- W2912746728 cites W1997854913 @default.
- W2912746728 cites W2003708679 @default.
- W2912746728 cites W2004076464 @default.
- W2912746728 cites W2005691917 @default.
- W2912746728 cites W2006725810 @default.
- W2912746728 cites W2007131731 @default.
- W2912746728 cites W2008618177 @default.
- W2912746728 cites W2009911130 @default.
- W2912746728 cites W2010407261 @default.
- W2912746728 cites W2014677321 @default.
- W2912746728 cites W2014716519 @default.
- W2912746728 cites W2014881508 @default.
- W2912746728 cites W2022080762 @default.
- W2912746728 cites W2023618834 @default.
- W2912746728 cites W2024301095 @default.
- W2912746728 cites W2027930674 @default.
- W2912746728 cites W2031121245 @default.
- W2912746728 cites W2031211461 @default.
- W2912746728 cites W2032861840 @default.
- W2912746728 cites W2033938388 @default.
- W2912746728 cites W2034620858 @default.
- W2912746728 cites W2037803579 @default.
- W2912746728 cites W2042326040 @default.
- W2912746728 cites W2043179564 @default.
- W2912746728 cites W2044257400 @default.
- W2912746728 cites W2045052883 @default.
- W2912746728 cites W2045273788 @default.
- W2912746728 cites W2050844892 @default.
- W2912746728 cites W2055671120 @default.
- W2912746728 cites W2056063805 @default.
- W2912746728 cites W2057487100 @default.
- W2912746728 cites W2058274420 @default.
- W2912746728 cites W2058657406 @default.
- W2912746728 cites W2061266080 @default.
- W2912746728 cites W2063338807 @default.
- W2912746728 cites W2065646518 @default.
- W2912746728 cites W2066556485 @default.
- W2912746728 cites W2067573815 @default.
- W2912746728 cites W2078604312 @default.
- W2912746728 cites W2078718449 @default.
- W2912746728 cites W2080592158 @default.
- W2912746728 cites W2080696123 @default.
- W2912746728 cites W2082105991 @default.
- W2912746728 cites W2083615209 @default.
- W2912746728 cites W2084939005 @default.
- W2912746728 cites W2084946181 @default.
- W2912746728 cites W2089163282 @default.
- W2912746728 cites W2089512600 @default.
- W2912746728 cites W2091101448 @default.
- W2912746728 cites W2091743979 @default.
- W2912746728 cites W2096803925 @default.
- W2912746728 cites W2099592894 @default.
- W2912746728 cites W2103274097 @default.
- W2912746728 cites W2104961127 @default.
- W2912746728 cites W2105280572 @default.
- W2912746728 cites W2106246537 @default.
- W2912746728 cites W2107277218 @default.