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- W2912750532 abstract "Background:Anti-C1q has been associated with systemic lupus erythematosus (SLE) as well as in other connective tissue diseases. They have been considered as a marker for disease activity and presence of nephritis in previous studiesObjectives:Aim of this study was to determine the prevalence of anti- C1q antibodies in the pediatric SLE population and to determine clinical associations of elevated anti- C1q antibody levels especially with lupus nephritis.Methods:Sera of 150 pediatric SLE patients who fulfilled ACR criteria for SLE were recruited. After obtaining informed consent, blood samples were tested for anti- C1q antibody by commercially available ELISA kit. Prevalence of anti-C1q and its association with lupus nephritis were determined. .Results:Out of total 150 children with SLE, anti- C1q positivity was present in 95 children(64%), at a cut off value of 20U/ml. Children with proteinuria, low C3, low C4 and anti dsDNA positivity had were significantly more likely to have anti- C1q antibody positivity.Children with lupus nephritis were significantly more likely to have anti C1q antibodies positive than children without renal involvement (74% vs.51% , p= 0.02). Among the children with lupus nephritis, children with active renal disease were more likely to haveanti- C1qpositivity than in children with quiescent disease (88% vs. 53% , p= 0.002). Anti-C1q antibodies had a sensitivity of 74% and specificity of 54% at a cut off value of 22U/L , for renal disease in pSLEConclusion:Out study confirms previous findings of the association of anti-C1q antibodies with nephritis and disease activity in pSLE. Anti-C1q antibody titers were found to have positive correlation with renal disease in children with pediatric SLE, and could be used as an adjunctive biomarker in monitoring disease activity in children with lupus nephritis" @default.
- W2912750532 created "2019-02-21" @default.
- W2912750532 creator A5046166987 @default.
- W2912750532 date "2018-05-01" @default.
- W2912750532 modified "2023-09-27" @default.
- W2912750532 title "Prevalence and clinical associations of anti-c1q antibodies in pediatric systemic lupus erythematosus" @default.
- W2912750532 hasPublicationYear "2018" @default.
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