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- W2912754730 abstract "Abstract Epithelial organ size and shape depend on cell shape changes, cell-matrix communication and apical membrane growth. The Drosophila embryonic tracheal network is an excellent model to study these processes. Here, we show that the transcriptional co-activator of the Hippo pathway, Yorkie (YAP in vertebrates), plays distinct roles in the developing Drosophila airways. Yorkie exerts a cytoplasmic function by binding Drosophila Twinstar, the orthologue of the vertebrate actin-severing protein Cofilin, to regulate F-actin levels and apical cell membrane size, which are required for proper tracheal tube elongation. Second, Yorkie controls water-tightness of tracheal tubes by transcriptional regulation of the enzyme δ-aminolevulinate synthase ( Alas ). We conclude that Yorkie has a dual role in tracheal development to ensure proper tracheal growth and functionality. Short Summary This work identified an alternative role of the transcriptional co-activator Yorkie (Yki) in controlling water impermeability and tube size of the developing Drosophila airways. Tracheal impermeability is triggered by Yki-mediated transcriptional regulation of δ-aminolevulinate synthase , Alas , whereas tube elongation is controlled by binding of Yki to the actin severing factor Twinstar." @default.
- W2912754730 created "2019-02-21" @default.
- W2912754730 creator A5002595262 @default.
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- W2912754730 date "2019-01-28" @default.
- W2912754730 modified "2023-09-26" @default.
- W2912754730 title "Yorkie controls tube length and apical barrier integrity in the developing<i>Drosophila</i>airways" @default.
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- W2912754730 doi "https://doi.org/10.1101/532325" @default.
- W2912754730 hasPublicationYear "2019" @default.
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