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- W2912755660 abstract "Abstract The current work describes the synthesis of new series of N‐(1‐(cyclohexylcarbamoyl) cyclohexyl)‐N‐phenylarylamides ( 10 a‐h ) and 3‐cyclohexyl‐1,2‐diphenyl and 2‐(substituted phenyl)‐1,3‐diazaspiro[4.5]decanes ( 12 a‐h ).The new compounds were screened for their anticonvulsant and antinociceptive activities using sodium valproate and tramadol hydrochloride, respectively as reference standards. 4‐Chloro‐N‐(1‐(cyclohexylcarbamoyl)cyclohexyl)‐N‐phenylbenzamide ( 10 b) , 3‐Cyclohexyl‐1,2‐diphenyl‐1,3‐diazaspiro[4.5]decane (12 a) and 3‐Cyclohexyl‐1‐phenyl‐2‐(3,4,5‐trimethoxyphenyl)‐1,3‐diazaspiro[4.5]decane (12 d) showed higher anticonvulsant activity than sodium valproate at dose 0.08 mmol/kg. On the other hand, 4‐Amino‐N‐(1‐(cyclohexylcarbamoyl) cyclohexyl)‐N‐phenylbenzamide (10 h) and 3‐Cyclohexyl‐1‐phenyl‐2‐(3,4,5‐trimethoxyphenyl)‐1,3‐diazaspiro[4.5]decane (12 d) exhibited higher antinociceptive potential in both intensity and duration than tramadol hydrochloride. The pharmacokinetics of the new compounds were calculated in‐ silico . Additionally, 3D pharmacophoric model was generated." @default.
- W2912755660 created "2019-02-21" @default.
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- W2912755660 date "2019-01-25" @default.
- W2912755660 modified "2023-09-25" @default.
- W2912755660 title "Synthesis, Molecular Modeling, Anticonvulsant and Antinociceptive Properties of New 1,1-Disubstituted Cyclohexane and 1,3-Diazaspiro[4.5]decane Derivatives" @default.
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- W2912755660 doi "https://doi.org/10.1002/slct.201803727" @default.
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