Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912755779> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2912755779 abstract "Developmental disorders associated with learning deficits, including Autism, have been linked to early-life immune activation, and notably, are male-biased. Microglia are the immune cells of the brain and are in constant communication with neurons, thus, microglia influence the function of surrounding neurons. Recent data indicate that microglia-neuron signaling is necessary for the proper formation of neural circuits during brain development. We determined that immune activation with lipopolysaccharide (LPS; 100ug/ml/kg) on postnatal day (P) 21 produces sex-dependent deficits in the emergence of hippocampal-dependent learning on P24 in rats. Gene expression analysis in the hippocampus at 2-, 4-, 8-, and 24-h following LPS showed sex differences in IL-1 β and IL-6 expression. Males, but not females, have a persistent decrease in BDNF expression starting 4hr post-LPS that persists until 24hr and an increase in C3 expression, an immune molecule that tags synapses for elimination, at 24hr. We are investigating whether we can rescue learning deficits by administering the microglia inhibitor minocycline at the time of LPS. We found a sex difference in the effectiveness of minocycline such that minocycline inhibits microglia in males, but is not as effective in females. Behavioral results following minocycline treatment will be discussed. Our data suggest that changes in microglia-neural communication following early-life immune activation are different in males and females, thus males and females may respond differently to therapies that target microglia." @default.
- W2912755779 created "2019-02-21" @default.
- W2912755779 creator A5013234745 @default.
- W2912755779 creator A5022580052 @default.
- W2912755779 date "2019-02-01" @default.
- W2912755779 modified "2023-09-25" @default.
- W2912755779 title "Abstract # 3149 Sex differences in the consequences of early-life immune activation on microglia-neural signaling and the ontogeny of hippocampal-dependent learning in the juvenile rat" @default.
- W2912755779 doi "https://doi.org/10.1016/j.bbi.2018.11.266" @default.
- W2912755779 hasPublicationYear "2019" @default.
- W2912755779 type Work @default.
- W2912755779 sameAs 2912755779 @default.
- W2912755779 citedByCount "0" @default.
- W2912755779 crossrefType "journal-article" @default.
- W2912755779 hasAuthorship W2912755779A5013234745 @default.
- W2912755779 hasAuthorship W2912755779A5022580052 @default.
- W2912755779 hasConcept C148762608 @default.
- W2912755779 hasConcept C15744967 @default.
- W2912755779 hasConcept C169760540 @default.
- W2912755779 hasConcept C203014093 @default.
- W2912755779 hasConcept C2776914184 @default.
- W2912755779 hasConcept C2778275353 @default.
- W2912755779 hasConcept C2778754761 @default.
- W2912755779 hasConcept C2779830541 @default.
- W2912755779 hasConcept C2781161787 @default.
- W2912755779 hasConcept C501593827 @default.
- W2912755779 hasConcept C86803240 @default.
- W2912755779 hasConcept C8891405 @default.
- W2912755779 hasConcept C89423630 @default.
- W2912755779 hasConceptScore W2912755779C148762608 @default.
- W2912755779 hasConceptScore W2912755779C15744967 @default.
- W2912755779 hasConceptScore W2912755779C169760540 @default.
- W2912755779 hasConceptScore W2912755779C203014093 @default.
- W2912755779 hasConceptScore W2912755779C2776914184 @default.
- W2912755779 hasConceptScore W2912755779C2778275353 @default.
- W2912755779 hasConceptScore W2912755779C2778754761 @default.
- W2912755779 hasConceptScore W2912755779C2779830541 @default.
- W2912755779 hasConceptScore W2912755779C2781161787 @default.
- W2912755779 hasConceptScore W2912755779C501593827 @default.
- W2912755779 hasConceptScore W2912755779C86803240 @default.
- W2912755779 hasConceptScore W2912755779C8891405 @default.
- W2912755779 hasConceptScore W2912755779C89423630 @default.
- W2912755779 hasLocation W29127557791 @default.
- W2912755779 hasOpenAccess W2912755779 @default.
- W2912755779 hasPrimaryLocation W29127557791 @default.
- W2912755779 hasRelatedWork W1901120187 @default.
- W2912755779 hasRelatedWork W2011693499 @default.
- W2912755779 hasRelatedWork W2079684474 @default.
- W2912755779 hasRelatedWork W2116956848 @default.
- W2912755779 hasRelatedWork W2186423026 @default.
- W2912755779 hasRelatedWork W2509408678 @default.
- W2912755779 hasRelatedWork W2762301721 @default.
- W2912755779 hasRelatedWork W3205311345 @default.
- W2912755779 hasRelatedWork W4286628586 @default.
- W2912755779 hasRelatedWork W4286826161 @default.
- W2912755779 isParatext "false" @default.
- W2912755779 isRetracted "false" @default.
- W2912755779 magId "2912755779" @default.
- W2912755779 workType "article" @default.