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• W2912760219 abstract "<h3>Rationale and Objectives</h3> To evaluate possible correlation between changes in apparent diffusion coefficient (ADC) and Ki-67 index as a result of neoadjuvant chemotherapy (NAC) in patients with invasive breast cancer. <h3>Methods and Materials</h3> Between February 2016 and October 2017, 87 patients with breast cancer underwent diffusion-weighted magnetic resonance imaging (b = 0 and 800 sec/mm²) before and after NAC. ADC and tumor diameter before and after NAC were compared to the Ki-67 index determined from biopsy or surgical specimens. <h3>Results</h3> Ki-67 index did not correlate significantly with ADC before NAC (<i>p</i> = 0.862) or afterwards (<i>p</i> = 0.292), nor did it correlate with tumor diameter before (<i>p</i> = 0.545) or afterwards (<i>p</i> = 0.478). However, change in ADC as a result of NAC correlated inversely with change in Ki-67 index (r = −0.326, <i>p</i> = 0.002). The percentage change in Ki-67 index did not correlate with the percentage change in ADC (<i>p</i> = 0.404). Similarly, the change in Ki-67 index or percentage change in that index did not correlate with the change in tumor diameter (<i>p</i> = 0.075) or percentage change in tumor diameter (<i>p</i> = 0.233). <h3>Conclusion</h3> Comparison of pre- and post-NAC ADC can be used to estimate the change in Ki-67 index in patients with invasive breast cancer." @default.
• W2912760219 created "2019-02-21" @default.
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• W2912760219 date "2019-10-01" @default.
• W2912760219 modified "2023-09-27" @default.
• W2912760219 title "Changes in Apparent Diffusion Coefficient as Surrogate Marker for Changes in Ki-67 Index Due to Neoadjuvant Chemotherapy in Patients with Invasive Breast Cancer" @default.
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• W2912760219 doi "https://doi.org/10.1016/j.acra.2019.01.007" @default.
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