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- W2912761459 endingPage "522" @default.
- W2912761459 startingPage "501" @default.
- W2912761459 abstract "Immune checkpoint molecules are important targets in cancer immunotherapy, but their association with prognosis in patients with head and neck cancer is controversial. In this meta-analysis, we searched for 12 immune checkpoint molecules in the PubMed, Embase and Cochrane Library databases and retrieved 52 studies with 7127 participants. Among the molecules included in the search, indoleamine 2, 3-dioxygenase (IDO), programmed death ligand 1 (PD-L1), and programmed death 1 (PD-1) met the inclusion criteria for further analysis. Higher expression of IDO was associated with poorer overall survival in head and neck cancer patients (P = 0.011), but higher expression of PD-L1 correlated with better overall survival specifically in nasopharyngeal carcinoma patients (P = 0.01). In a sensitivity analysis, higher PD-L1 expression correlated with better progression-free survival (P = 0.043), and was associated with better overall survival in Caucasian subjects (P = 0.02), nasopharyngeal carcinoma patients (P = 0.015), and studies with small sample sizes (P = 0.001). PD-1 had no prognostic significance. There was no publication bias affecting the results. Thus, among the immune checkpoint molecules, IDO and PD-L1 are potential prognostic predictors in head and neck cancer." @default.
- W2912761459 created "2019-02-21" @default.
- W2912761459 creator A5001341236 @default.
- W2912761459 creator A5014273626 @default.
- W2912761459 creator A5032974852 @default.
- W2912761459 creator A5036016529 @default.
- W2912761459 creator A5036666740 @default.
- W2912761459 creator A5072820962 @default.
- W2912761459 date "2019-01-22" @default.
- W2912761459 modified "2023-09-27" @default.
- W2912761459 title "Prognostic value of immune checkpoint molecules in head and neck cancer: a meta-analysis" @default.
- W2912761459 cites W1869500669 @default.
- W2912761459 cites W1939817548 @default.
- W2912761459 cites W1953222889 @default.
- W2912761459 cites W1964106115 @default.
- W2912761459 cites W1966064788 @default.
- W2912761459 cites W1979423827 @default.
- W2912761459 cites W1979811833 @default.
- W2912761459 cites W1981885178 @default.
- W2912761459 cites W1982022381 @default.
- W2912761459 cites W2007980875 @default.
- W2912761459 cites W2020720650 @default.
- W2912761459 cites W2024575631 @default.
- W2912761459 cites W2031391029 @default.
- W2912761459 cites W2033932056 @default.
- W2912761459 cites W2039123767 @default.
- W2912761459 cites W2047951773 @default.
- W2912761459 cites W2060400731 @default.
- W2912761459 cites W2071606440 @default.
- W2912761459 cites W2075642745 @default.
- W2912761459 cites W2083262432 @default.
- W2912761459 cites W2088095316 @default.
- W2912761459 cites W2089821881 @default.
- W2912761459 cites W2091312795 @default.
- W2912761459 cites W2099432296 @default.
- W2912761459 cites W2100088098 @default.
- W2912761459 cites W2104350866 @default.
- W2912761459 cites W2107283868 @default.
- W2912761459 cites W2108972938 @default.
- W2912761459 cites W2112951197 @default.
- W2912761459 cites W2136731993 @default.
- W2912761459 cites W2167130223 @default.
- W2912761459 cites W2173271323 @default.
- W2912761459 cites W2176647747 @default.
- W2912761459 cites W2179501428 @default.
- W2912761459 cites W2286633367 @default.
- W2912761459 cites W2289333985 @default.
- W2912761459 cites W2298868531 @default.
- W2912761459 cites W2299084952 @default.
- W2912761459 cites W2337314195 @default.
- W2912761459 cites W2345415641 @default.
- W2912761459 cites W2461385029 @default.
- W2912761459 cites W2475368493 @default.
- W2912761459 cites W2515914372 @default.
- W2912761459 cites W2527850257 @default.
- W2912761459 cites W2529484692 @default.
- W2912761459 cites W2539222431 @default.
- W2912761459 cites W2548066494 @default.
- W2912761459 cites W2556232360 @default.
- W2912761459 cites W2560367415 @default.
- W2912761459 cites W2567510695 @default.
- W2912761459 cites W2582289619 @default.
- W2912761459 cites W2588197111 @default.
- W2912761459 cites W2588574345 @default.
- W2912761459 cites W2588681363 @default.
- W2912761459 cites W2590022828 @default.
- W2912761459 cites W2597186676 @default.
- W2912761459 cites W2602728021 @default.
- W2912761459 cites W2607567876 @default.
- W2912761459 cites W2610805567 @default.
- W2912761459 cites W2612028429 @default.
- W2912761459 cites W2613520543 @default.
- W2912761459 cites W2625997216 @default.
- W2912761459 cites W2626773261 @default.
- W2912761459 cites W2724946178 @default.
- W2912761459 cites W2725110405 @default.
- W2912761459 cites W2732036046 @default.
- W2912761459 cites W2732565107 @default.
- W2912761459 cites W2735001208 @default.
- W2912761459 cites W2737405537 @default.
- W2912761459 cites W2743048167 @default.
- W2912761459 cites W2756279299 @default.
- W2912761459 cites W2758617629 @default.
- W2912761459 cites W2761923972 @default.
- W2912761459 cites W2768788519 @default.
- W2912761459 cites W2778348494 @default.
- W2912761459 cites W2785374083 @default.
- W2912761459 cites W2789435720 @default.
- W2912761459 cites W2793362544 @default.
- W2912761459 cites W2796055798 @default.
- W2912761459 cites W2799403067 @default.
- W2912761459 cites W2800747877 @default.
- W2912761459 cites W2801219124 @default.
- W2912761459 cites W2803936145 @default.
- W2912761459 cites W2804791676 @default.
- W2912761459 cites W2833772119 @default.
- W2912761459 cites W2917837889 @default.
- W2912761459 doi "https://doi.org/10.18632/aging.101756" @default.