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• W2912765869 abstract "Abstract Errors in gene transcription can be costly, and organisms have evolved to prevent their occurrence or mitigate their costs. The simplest interpretation of the drift barrier hypothesis suggests that species with larger population sizes would have lower transcriptional error rates. However, Escherichia coli seems to have a higher transcriptional error rate than species with lower effective population sizes, e.g. Saccharomyces cerevisiae . This could be explained if selection in E. coli were strong enough to maintain adaptations that mitigate the consequences of transcriptional errors through robustness, on a gene by gene basis, obviating the need for low transcriptional error rates and associated costs of global proofreading. Here we note that if selection is powerful enough to evolve local robustness, selection should also be powerful enough to locally reduce error rates. We therefore predict that transcriptional error rates will be lower in highly abundant proteins on which selection is strongest. However, we only expect this result when error rates are high enough to significantly impact fitness. As expected, we find such a relationship between expression and transcriptional error rate for non C➔U errors in E. coli (especially G➔A), but not in S. cerevisiae . We do not find this pattern for C➔U changes in E. coli , presumably because most deamination events occurred during sample preparation, but do for C➔U changes in S. cerevisiae , supporting the interpretation that C➔U error rates estimated with an improved protocol, and which occur at rates comparable to E. coli non C➔U errors, are biological." @default.
• W2912765869 created "2019-02-21" @default.
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• W2912765869 date "2019-02-19" @default.
• W2912765869 modified "2023-10-17" @default.
• W2912765869 title "High transcriptional error rates vary as a function of gene expression level" @default.
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• W2912765869 doi "https://doi.org/10.1101/554329" @default.
• W2912765869 hasPublicationYear "2019" @default.
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