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- W2912772553 abstract "As one of the most dangerous pathogens in the aquaculture of crustaceans, white spot syndrome virus (WSSV) induces a high mortality rate and huge economic losses in crustacean industries. Up to now, there are no commercially available drugs to control the virus. Thus, it is important to find an antiviral drug to combat highly lethal WSSV outbreaks. In the present study, the anti-WSSV activities of 23 medicinal plant extracts were investigated in crayfish Procambarus clarkii. In order to better evaluate the antiviral activities of plant extracts, it was important to build a WSSV infection model in crayfish first. The results of WSSV infection showed that WSSV could infect most tissues of crayfish, and the heaviest infected tissue is the gills. The time course curve of WSSV amount change in crayfish assumed a very similar shape with the typical viral one-step growth curve. On the basis of virus infection model, the anti-WSSV activities of 23 plant extracts were investigated. Among these plants, Gardenia jasminoides showed the highest inhibition on WSSV replication, with 92.31%. A further study showed that G. jasminoides improved survival rate of WSSV-challenged crayfish. Mechanistically, G. jasminoides reduced Hsp70 expression and virus immediate-early gene ie1, early gene DNApol, late gene VP28 transcript, indicating that G. jasminoides inhibited WSSV replication via blocking the immediate-early stage gene ie1 transcript. Furthermore, the expression of antioxidants (cMnSOD, mMnSOD, CAT and GST) and apoptosis-related factors (Bax and Bax-inhibitor-1) were significantly increased in G. jasminoides-treated crayfish, suggesting that G. jasminoides could modulate apoptosis-related factors and possessed anti-oxidative activity in crayfish. Taken together, G. jasminoides could inhibit WSSV replication and improve survival rate of WSSV-challenged crayfish. This outcome offers a scientific basis for the use of extracts of G. jasminoides against WSSV, and it is worth focusing on the isolation and identification of effective active compounds from G. jasminoides." @default.
- W2912772553 created "2019-02-21" @default.
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- W2912772553 date "2019-04-01" @default.
- W2912772553 modified "2023-10-17" @default.
- W2912772553 title "Gardenia jasminoides Ellis inhibit white spot syndrome virus replication in red swamp crayfish Procambarus clarkii" @default.
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- W2912772553 doi "https://doi.org/10.1016/j.aquaculture.2019.02.008" @default.
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