FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912772982> ?p ?o ?g. }

• W2912772982 endingPage "376" @default.
• W2912772982 startingPage "368" @default.
• W2912772982 abstract "Performing individual pharmacokinetics (PK) studies in clinical practice can be simplified by adopting population PK-based profiling on limited post-infusion samples. The objective of this study was to assess the impact of population PK in tailoring prophylaxis in patients with haemophilia A. Individual weekly treatment plans were developed considering predicted plasma factor activity levels and patients' lifestyle. Patients were trained using a visual traffic-light scheme to help modulate their level of physical activity with respect to factor infusions timing. Annualized joint bleeding rate (ABJR), haemophilia-specific quality of life questionnaire for adults (Haemo-QoL-A) and factor utilization were measured for 12 months before and after tailoring, compared within patients and analysed separately for those previously on prophylaxis (P), situational prophylaxis (SP) or on-demand (OD). Sixteen patients previously on P, 10 on SP and 10 on OD were enrolled in the study. The median (lower, upper quartile) ABJR changed from 2.0 (0, 4.0) to 0 (0, 1.6) for P (p = 0.003), from 2.0 (2.0, 13.6) to 3.0 (1.4, 7.2) for SP (p = 0.183) and from 16.0 (13.0, 25.0) to 2.3 (0, 5.0) for OD (p = 0.003). The Haemo-QoL-A total score improved for 58% of P, 50% of SP and 29% of OD patients. Factor utilization (IU/kg/patient/year) increased by 2,400 (121; 2,586) for P, 1,052 (308; 1,578) for SP and 2,086 (1,498; 2,576) for OD. One of 138 measurements demonstrated a factor activity level below the critical threshold of 0.03 IU/mL while the predicted level was above the threshold. Implementing tailored prophylaxis using a Bayesian forecasting approach in a routine clinical practice setting may improve haemophilia clinical outcomes." @default.
• W2912772982 created "2019-02-21" @default.
• W2912772982 creator A5003655272 @default.
• W2912772982 creator A5004825755 @default.
• W2912772982 creator A5005291648 @default.
• W2912772982 creator A5019411028 @default.
• W2912772982 creator A5026187977 @default.
• W2912772982 creator A5026804416 @default.
• W2912772982 creator A5031015703 @default.
• W2912772982 creator A5032788004 @default.
• W2912772982 creator A5045344606 @default.
• W2912772982 creator A5086326383 @default.
• W2912772982 date "2019-01-27" @default.
• W2912772982 modified "2023-09-27" @default.
• W2912772982 title "Impact of Adopting Population Pharmacokinetics for Tailoring Prophylaxis in Haemophilia A Patients: A Historically Controlled Observational Study" @default.
• W2912772982 cites W1678213225 @default.
• W2912772982 cites W1833960158 @default.
• W2912772982 cites W1997860401 @default.
• W2912772982 cites W2003240945 @default.
• W2912772982 cites W2013607072 @default.
• W2912772982 cites W2015795623 @default.
• W2912772982 cites W2034317941 @default.
• W2912772982 cites W2076845477 @default.
• W2912772982 cites W2101407724 @default.
• W2912772982 cites W2111622100 @default.
• W2912772982 cites W2113438234 @default.
• W2912772982 cites W2113779127 @default.
• W2912772982 cites W2114691160 @default.
• W2912772982 cites W2147873611 @default.
• W2912772982 cites W2159478354 @default.
• W2912772982 cites W2509894219 @default.
• W2912772982 cites W2560364466 @default.
• W2912772982 cites W2565753485 @default.
• W2912772982 cites W2578385150 @default.
• W2912772982 cites W2601867295 @default.
• W2912772982 cites W2729612066 @default.
• W2912772982 cites W2761634319 @default.
• W2912772982 cites W2777592132 @default.
• W2912772982 cites W2791162320 @default.
• W2912772982 doi "https://doi.org/10.1055/s-0039-1677700" @default.
• W2912772982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30685872" @default.
• W2912772982 hasPublicationYear "2019" @default.
• W2912772982 type Work @default.
• W2912772982 sameAs 2912772982 @default.
• W2912772982 citedByCount "20" @default.
• W2912772982 countsByYear W29127729822019 @default.
• W2912772982 countsByYear W29127729822020 @default.
• W2912772982 countsByYear W29127729822021 @default.
• W2912772982 countsByYear W29127729822022 @default.
• W2912772982 countsByYear W29127729822023 @default.
• W2912772982 crossrefType "journal-article" @default.
• W2912772982 hasAuthorship W2912772982A5003655272 @default.
• W2912772982 hasAuthorship W2912772982A5004825755 @default.
• W2912772982 hasAuthorship W2912772982A5005291648 @default.
• W2912772982 hasAuthorship W2912772982A5019411028 @default.
• W2912772982 hasAuthorship W2912772982A5026187977 @default.
• W2912772982 hasAuthorship W2912772982A5026804416 @default.
• W2912772982 hasAuthorship W2912772982A5031015703 @default.
• W2912772982 hasAuthorship W2912772982A5032788004 @default.
• W2912772982 hasAuthorship W2912772982A5045344606 @default.
• W2912772982 hasAuthorship W2912772982A5086326383 @default.
• W2912772982 hasBestOaLocation W29127729821 @default.
• W2912772982 hasConcept C112705442 @default.
• W2912772982 hasConcept C126322002 @default.
• W2912772982 hasConcept C141071460 @default.
• W2912772982 hasConcept C187212893 @default.
• W2912772982 hasConcept C23131810 @default.
• W2912772982 hasConcept C2777232031 @default.
• W2912772982 hasConcept C2778385053 @default.
• W2912772982 hasConcept C2908647359 @default.
• W2912772982 hasConcept C44249647 @default.
• W2912772982 hasConcept C68443243 @default.
• W2912772982 hasConcept C71924100 @default.
• W2912772982 hasConcept C99454951 @default.
• W2912772982 hasConceptScore W2912772982C112705442 @default.
• W2912772982 hasConceptScore W2912772982C126322002 @default.
• W2912772982 hasConceptScore W2912772982C141071460 @default.
• W2912772982 hasConceptScore W2912772982C187212893 @default.
• W2912772982 hasConceptScore W2912772982C23131810 @default.
• W2912772982 hasConceptScore W2912772982C2777232031 @default.
• W2912772982 hasConceptScore W2912772982C2778385053 @default.
• W2912772982 hasConceptScore W2912772982C2908647359 @default.
• W2912772982 hasConceptScore W2912772982C44249647 @default.
• W2912772982 hasConceptScore W2912772982C68443243 @default.
• W2912772982 hasConceptScore W2912772982C71924100 @default.
• W2912772982 hasConceptScore W2912772982C99454951 @default.
• W2912772982 hasIssue "03" @default.
• W2912772982 hasLocation W29127729821 @default.
• W2912772982 hasLocation W29127729822 @default.
• W2912772982 hasOpenAccess W2912772982 @default.
• W2912772982 hasPrimaryLocation W29127729821 @default.
• W2912772982 hasRelatedWork W1969419914 @default.
• W2912772982 hasRelatedWork W1978184135 @default.
• W2912772982 hasRelatedWork W1989059436 @default.
• W2912772982 hasRelatedWork W2054017948 @default.
• W2912772982 hasRelatedWork W2057949657 @default.
• W2912772982 hasRelatedWork W2123242870 @default.
• W2912772982 hasRelatedWork W2884858143 @default.

• next