Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912775396> ?p ?o ?g. }
- W2912775396 endingPage "e14333" @default.
- W2912775396 startingPage "e14333" @default.
- W2912775396 abstract "Many molecular epidemiology studies have reported an association between the combined effects of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) polymorphisms on breast cancer risk. However, the results have been controversial.A meta-analysis was performed to clarify this issue.Meta-analysis of observational studies in epidemiology guidelines was used. Pooled the crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model or fixed-effects model. Several subgroup analyses were conducted by ethnicity, source of control, matching, and menopausal status. In addition, we also performed sensitivity analysis and publication bias. Moreover, a false-positive report probability (FPRP) test was applied to assess positive results.A significantly increased breast cancer risk was observed in overall population (GSTM1 null/GSTT1 present [- +] vs GSTM1 present/GSTT1 present [+ +]: OR = 1.19, 95% CI: 1.03-1.36, GSTM1 null/GSTT1 null [- -] vs + +: OR = 1.63, 95% CI: 1.29-2.06, (- +) + GSTM1 present/GSTT1 null (+ -) vs + +: OR = 1.17, 95% CI: 1.05-1.31, (- +) + (+ -) + (- -) vs + +: OR = 1.27, 95% CI: 1.12-1.44, and - - vs (- +) + (+ -) + (+ +): OR = 1.39, 95% CI: 1.17-1.66) and several subgroup analyses, such as Caucasians, Indians, postmenopausal women, and so on. However, positive results were only considered noteworthy in overall population (- - vs + +: FPRP = 0.150 and (- +) + (+ -) + (- -) vs + +: FPRP = 0.162). Moreover, no significant association was observed when we used the trim and fill method to adjust the pooled data from all populations. Further, none of positive results of sensitivity analysis were considered noteworthy (FPRP >0.2).These positive findings should be interpreted with caution and indicate that an increased breast cancer risk may most likely result from false-positive results, rather than from true associations or biological factors on the combined effects of GSTM1 and GSTT1. Future studies should be based on sample sizes well-powered and attention needs to be paid to study design to further identify this issue." @default.
- W2912775396 created "2019-02-21" @default.
- W2912775396 creator A5027212917 @default.
- W2912775396 creator A5030904824 @default.
- W2912775396 creator A5051235305 @default.
- W2912775396 creator A5056597741 @default.
- W2912775396 creator A5061672505 @default.
- W2912775396 date "2019-02-01" @default.
- W2912775396 modified "2023-09-25" @default.
- W2912775396 title "Combined effects of GSTM1 and GSTT1 polymorphisms on breast cancer risk" @default.
- W2912775396 cites W113982714 @default.
- W2912775396 cites W1490968191 @default.
- W2912775396 cites W1946772620 @default.
- W2912775396 cites W1964435302 @default.
- W2912775396 cites W1969784655 @default.
- W2912775396 cites W1973275034 @default.
- W2912775396 cites W1974119063 @default.
- W2912775396 cites W1976346227 @default.
- W2912775396 cites W1976969965 @default.
- W2912775396 cites W1991791764 @default.
- W2912775396 cites W1994573648 @default.
- W2912775396 cites W1998358624 @default.
- W2912775396 cites W2000551727 @default.
- W2912775396 cites W2004509145 @default.
- W2912775396 cites W2005707286 @default.
- W2912775396 cites W2006661062 @default.
- W2912775396 cites W2006895891 @default.
- W2912775396 cites W2007657603 @default.
- W2912775396 cites W2009692616 @default.
- W2912775396 cites W2016165074 @default.
- W2912775396 cites W2019957214 @default.
- W2912775396 cites W2025383700 @default.
- W2912775396 cites W2026017532 @default.
- W2912775396 cites W2030822687 @default.
- W2912775396 cites W2042418911 @default.
- W2912775396 cites W2043527806 @default.
- W2912775396 cites W2046750894 @default.
- W2912775396 cites W2052447033 @default.
- W2912775396 cites W2053040843 @default.
- W2912775396 cites W2053576831 @default.
- W2912775396 cites W2055421336 @default.
- W2912775396 cites W2055489824 @default.
- W2912775396 cites W2062380946 @default.
- W2912775396 cites W2068169748 @default.
- W2912775396 cites W2071385861 @default.
- W2912775396 cites W2074191613 @default.
- W2912775396 cites W2074621147 @default.
- W2912775396 cites W2102945991 @default.
- W2912775396 cites W2104895648 @default.
- W2912775396 cites W2105309532 @default.
- W2912775396 cites W2107328434 @default.
- W2912775396 cites W2109305719 @default.
- W2912775396 cites W2119495036 @default.
- W2912775396 cites W2121637782 @default.
- W2912775396 cites W2121939381 @default.
- W2912775396 cites W2125435699 @default.
- W2912775396 cites W2128201302 @default.
- W2912775396 cites W2129724171 @default.
- W2912775396 cites W2129813254 @default.
- W2912775396 cites W2135230337 @default.
- W2912775396 cites W2137156807 @default.
- W2912775396 cites W2142621268 @default.
- W2912775396 cites W2150000105 @default.
- W2912775396 cites W2154440940 @default.
- W2912775396 cites W2154746176 @default.
- W2912775396 cites W2155487288 @default.
- W2912775396 cites W2157823046 @default.
- W2912775396 cites W2159228883 @default.
- W2912775396 cites W2161131703 @default.
- W2912775396 cites W2165305265 @default.
- W2912775396 cites W2165374503 @default.
- W2912775396 cites W2181909974 @default.
- W2912775396 cites W2279355599 @default.
- W2912775396 cites W2312482229 @default.
- W2912775396 cites W2355953728 @default.
- W2912775396 cites W2375799525 @default.
- W2912775396 cites W2407955315 @default.
- W2912775396 cites W2411329752 @default.
- W2912775396 cites W2416042712 @default.
- W2912775396 cites W273952518 @default.
- W2912775396 cites W96002820 @default.
- W2912775396 doi "https://doi.org/10.1097/md.0000000000014333" @default.
- W2912775396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6380837" @default.
- W2912775396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30732156" @default.
- W2912775396 hasPublicationYear "2019" @default.
- W2912775396 type Work @default.
- W2912775396 sameAs 2912775396 @default.
- W2912775396 citedByCount "3" @default.
- W2912775396 countsByYear W29127753962019 @default.
- W2912775396 countsByYear W29127753962020 @default.
- W2912775396 countsByYear W29127753962021 @default.
- W2912775396 crossrefType "journal-article" @default.
- W2912775396 hasAuthorship W2912775396A5027212917 @default.
- W2912775396 hasAuthorship W2912775396A5030904824 @default.
- W2912775396 hasAuthorship W2912775396A5051235305 @default.
- W2912775396 hasAuthorship W2912775396A5056597741 @default.
- W2912775396 hasAuthorship W2912775396A5061672505 @default.
- W2912775396 hasBestOaLocation W29127753961 @default.