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• W2912778251 abstract "Abstract The blood-brain barrier (BBB) has a major role in maintaining brain homeostasis through the specialized function of brain endothelial cells (BECs). Inflammation of the BECs and loss of their neuroprotective properties is associated with several neurological disorders, including the chronic neuro-inflammatory disorder multiple sclerosis (MS). Yet, the underlying mechanisms of a defective BBB in MS remain largely unknown. Endothelial to mesenchymal transition (EndoMT) is a pathophysiological process in which endothelial cells lose their specialized function and de-differentiate into mesenchymal cells. This transition is characterized by an increase in EndoMT-related transcription factors (TFs), a downregulation of brain endothelial markers, and an upregulation of mesenchymal markers accompanied by morphological changes associated with cytoskeleton reorganization. Here, we postulate that EndoMT drives BEC de-differentiation, mediates inflammation-induced human BECs dysfunction, and may play a role in MS pathophysiology. We provide evidence that stimulation of human BECs with transforming growth factor (TGF)-β1 and interleukin (IL)-1β promotes EndoMT, a process in which the TF SNAI1, a master regulator of EndoMT, plays a crucial role. We demonstrate the involvement of TGF-β activated kinase 1 (TAK1) in EndoMT induction in BECs. Finally, immunohistochemical analysis revealed EndoMT-associated alterations in the brain vasculature of human post-mortem MS brain tissues. Taken together, our novel findings provide a better understanding of the molecular mechanisms underlying BECs dysfunction during MS pathology and can be used to develop new potential therapeutic strategies to restore BBB function." @default.
• W2912778251 created "2019-02-21" @default.
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• W2912778251 date "2019-01-18" @default.
• W2912778251 modified "2023-10-07" @default.
• W2912778251 title "Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology" @default.
• W2912778251 cites W1495151309 @default.
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• W2912778251 cites W1608424471 @default.
• W2912778251 cites W1630758895 @default.
• W2912778251 cites W1806730902 @default.
• W2912778251 cites W1929386789 @default.
• W2912778251 cites W1964847767 @default.
• W2912778251 cites W1967948598 @default.
• W2912778251 cites W1973763077 @default.
• W2912778251 cites W1981348175 @default.
• W2912778251 cites W1981673516 @default.
• W2912778251 cites W1985775190 @default.
• W2912778251 cites W1986285940 @default.
• W2912778251 cites W1992883702 @default.
• W2912778251 cites W1995037165 @default.
• W2912778251 cites W1996249363 @default.
• W2912778251 cites W1998000193 @default.
• W2912778251 cites W2000463314 @default.
• W2912778251 cites W2000571234 @default.
• W2912778251 cites W2009541928 @default.
• W2912778251 cites W2015541518 @default.
• W2912778251 cites W2022194518 @default.
• W2912778251 cites W2025985350 @default.
• W2912778251 cites W2038628992 @default.
• W2912778251 cites W2039057009 @default.
• W2912778251 cites W2047406653 @default.
• W2912778251 cites W2054888910 @default.
• W2912778251 cites W2055823942 @default.
• W2912778251 cites W2059421466 @default.
• W2912778251 cites W2065524737 @default.
• W2912778251 cites W2068200901 @default.
• W2912778251 cites W2071046812 @default.
• W2912778251 cites W2072505432 @default.
• W2912778251 cites W2073235331 @default.
• W2912778251 cites W2084419599 @default.
• W2912778251 cites W2091478649 @default.
• W2912778251 cites W2093412595 @default.
• W2912778251 cites W2095370244 @default.
• W2912778251 cites W2098345971 @default.
• W2912778251 cites W2102103202 @default.
• W2912778251 cites W2105185169 @default.
• W2912778251 cites W2107798346 @default.
• W2912778251 cites W2113570143 @default.
• W2912778251 cites W2117969431 @default.
• W2912778251 cites W2131432937 @default.
• W2912778251 cites W2135919238 @default.
• W2912778251 cites W2136119693 @default.
• W2912778251 cites W2142517519 @default.
• W2912778251 cites W2143145016 @default.
• W2912778251 cites W2143452090 @default.
• W2912778251 cites W2154589460 @default.
• W2912778251 cites W2154853638 @default.
• W2912778251 cites W2155075033 @default.
• W2912778251 cites W2159821105 @default.
• W2912778251 cites W2161918376 @default.
• W2912778251 cites W2162417460 @default.
• W2912778251 cites W2162978315 @default.
• W2912778251 cites W2164717367 @default.
• W2912778251 cites W2165386666 @default.
• W2912778251 cites W2175209522 @default.
• W2912778251 cites W2255585558 @default.
• W2912778251 cites W2313288017 @default.
• W2912778251 cites W2317539243 @default.
• W2912778251 cites W2418154035 @default.
• W2912778251 cites W2462416197 @default.
• W2912778251 cites W2575770495 @default.
• W2912778251 cites W2587625705 @default.
• W2912778251 cites W2588949028 @default.
• W2912778251 cites W2601584926 @default.
• W2912778251 cites W2608107406 @default.
• W2912778251 cites W2612661993 @default.
• W2912778251 cites W2742623114 @default.
• W2912778251 cites W2765567550 @default.
• W2912778251 cites W2767779948 @default.
• W2912778251 cites W2781793836 @default.
• W2912778251 cites W4248259718 @default.
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• W2912778251 doi "https://doi.org/10.1038/s41419-018-1294-2" @default.
• W2912778251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6361981" @default.
• W2912778251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30718504" @default.
• W2912778251 hasPublicationYear "2019" @default.
• W2912778251 type Work @default.
• W2912778251 sameAs 2912778251 @default.

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