FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912778487> ?p ?o ?g. }

• W2912778487 endingPage "3792" @default.
• W2912778487 startingPage "3784" @default.
• W2912778487 abstract "In their natural habitat of rotting fruit, the nematode Caenorhabditis elegans feeds on the complex bacterial communities that thrive in this rich growth medium. Hundreds of diverse bacterial strains cultured from such rotting fruit allow C. elegans growth and reproduction when tested individually. In screens for C. elegans responses to single bacterial strains associated with nematodes in fruit, we found that Rhizobium causes a genome instability phenotype; we observed abnormally long or fragmented intestinal nuclei due to aberrant nuclear division, or defective karyokinesis. The karyokinesis defects were restricted to intestinal cells and required close proximity between bacteria and the worm. A genetic screen for C. elegans mutations that cause the same intestinal karyokinesis defect followed by genome sequencing of the isolated mutant strains identified mutations that disrupt DNA damage repair pathways, suggesting that Rhizobium may cause DNA damage in C. elegans intestinal cells. We hypothesized that such DNA damage is caused by reactive oxygen species produced by Rhizobium and found that hydrogen peroxide added to benign Escherichia coli can cause the same intestinal karyokinesis defects in WT C. elegans Supporting this model, free radical scavengers suppressed the Rhizobium-induced C. elegans DNA damage. Thus, Rhizobium may signal to eukaryotic hosts via reactive oxygen species, and the host may respond with DNA damage repair pathways." @default.
• W2912778487 created "2019-02-21" @default.
• W2912778487 creator A5066998461 @default.
• W2912778487 creator A5091570349 @default.
• W2912778487 date "2019-02-11" @default.
• W2912778487 modified "2023-09-29" @default.
• W2912778487 title "<i>Rhizobium</i> induces DNA damage in <i>Caenorhabditis elegans</i> intestinal cells" @default.
• W2912778487 cites W121254590 @default.
• W2912778487 cites W1531420541 @default.
• W2912778487 cites W1944127002 @default.
• W2912778487 cites W1971059223 @default.
• W2912778487 cites W1985810199 @default.
• W2912778487 cites W1986006829 @default.
• W2912778487 cites W1993519767 @default.
• W2912778487 cites W1994456266 @default.
• W2912778487 cites W1995317658 @default.
• W2912778487 cites W1997684038 @default.
• W2912778487 cites W2009464651 @default.
• W2912778487 cites W2026932718 @default.
• W2912778487 cites W2028585334 @default.
• W2912778487 cites W2035680172 @default.
• W2912778487 cites W2038561084 @default.
• W2912778487 cites W2040050768 @default.
• W2912778487 cites W2046835799 @default.
• W2912778487 cites W2050639627 @default.
• W2912778487 cites W2053741276 @default.
• W2912778487 cites W2055159418 @default.
• W2912778487 cites W2057810394 @default.
• W2912778487 cites W2058192652 @default.
• W2912778487 cites W2064144155 @default.
• W2912778487 cites W2068008287 @default.
• W2912778487 cites W2068535140 @default.
• W2912778487 cites W2069480047 @default.
• W2912778487 cites W2069684322 @default.
• W2912778487 cites W2078271301 @default.
• W2912778487 cites W2091967468 @default.
• W2912778487 cites W2095785516 @default.
• W2912778487 cites W2098245314 @default.
• W2912778487 cites W2099174032 @default.
• W2912778487 cites W2100365580 @default.
• W2912778487 cites W2101595316 @default.
• W2912778487 cites W2102766053 @default.
• W2912778487 cites W2107942098 @default.
• W2912778487 cites W2112132467 @default.
• W2912778487 cites W2113453462 @default.
• W2912778487 cites W2115635362 @default.
• W2912778487 cites W2116864763 @default.
• W2912778487 cites W2117087393 @default.
• W2912778487 cites W2122218171 @default.
• W2912778487 cites W2135419313 @default.
• W2912778487 cites W2136261717 @default.
• W2912778487 cites W2136769112 @default.
• W2912778487 cites W2146763497 @default.
• W2912778487 cites W2148856173 @default.
• W2912778487 cites W2155000552 @default.
• W2912778487 cites W2155557838 @default.
• W2912778487 cites W2156058796 @default.
• W2912778487 cites W2165970635 @default.
• W2912778487 cites W2170164822 @default.
• W2912778487 cites W2170741963 @default.
• W2912778487 cites W2172117086 @default.
• W2912778487 cites W2317201147 @default.
• W2912778487 cites W2346617299 @default.
• W2912778487 cites W2433871124 @default.
• W2912778487 cites W2579047952 @default.
• W2912778487 cites W2591651359 @default.
• W2912778487 cites W2594113879 @default.
• W2912778487 cites W2611331868 @default.
• W2912778487 cites W2620966823 @default.
• W2912778487 cites W2755450929 @default.
• W2912778487 cites W33256975 @default.
• W2912778487 cites W4236725824 @default.
• W2912778487 doi "https://doi.org/10.1073/pnas.1815656116" @default.
• W2912778487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6397575" @default.
• W2912778487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30808764" @default.
• W2912778487 hasPublicationYear "2019" @default.
• W2912778487 type Work @default.
• W2912778487 sameAs 2912778487 @default.
• W2912778487 citedByCount "17" @default.
• W2912778487 countsByYear W29127784872019 @default.
• W2912778487 countsByYear W29127784872020 @default.
• W2912778487 countsByYear W29127784872021 @default.
• W2912778487 countsByYear W29127784872022 @default.
• W2912778487 countsByYear W29127784872023 @default.
• W2912778487 crossrefType "journal-article" @default.
• W2912778487 hasAuthorship W2912778487A5066998461 @default.
• W2912778487 hasAuthorship W2912778487A5091570349 @default.
• W2912778487 hasBestOaLocation W29127784871 @default.
• W2912778487 hasConcept C104317684 @default.
• W2912778487 hasConcept C143065580 @default.
• W2912778487 hasConcept C143425029 @default.
• W2912778487 hasConcept C2776496032 @default.
• W2912778487 hasConcept C2778944004 @default.
• W2912778487 hasConcept C2780434414 @default.
• W2912778487 hasConcept C523546767 @default.
• W2912778487 hasConcept C54355233 @default.
• W2912778487 hasConcept C552990157 @default.
• W2912778487 hasConcept C86803240 @default.

• next