Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912783833> ?p ?o ?g. }
- W2912783833 endingPage "13" @default.
- W2912783833 startingPage "1" @default.
- W2912783833 abstract "The redox homeostasis of cytoplasm is maintained by a series of disulfide exchange reactions mediated by proteins belonging to the thioredoxin superfamily. Thioredoxin and thioredoxin reductase, being the major members of the family, play a key role in oxidative stress response of Staphylococcus aureus. In this report, we have identified and characterised an active thioredoxin system of the mentioned pathogen. Crystal structure of thioredoxin2 (SaTrx2) in its reduced form reveals that it contains the conserved redox active WCXXC motif and a thioredoxin fold. Thioredoxin reductase2 (SaTR2) is a flavoprotein and consists of two Rossmann folds as the binding sites for FAD and NADPH. Crystal structure of the SaTR2 holoenzyme shows that the protein consists of two domains and the catalytic site comprises of an intramolecular disulfide bond formed between two sequentially distal cysteine residues. Biophysical and biochemical studies unveil that SaTrx2 and SaTR2 can physically interact in solution and in the course of sustaining the redox equilibrium, the latter reduces the former. Molecular docking has been performed to illustrate the interface formed between SaTrx2 and SaTR2 during the disulfide exchange reaction." @default.
- W2912783833 created "2019-02-21" @default.
- W2912783833 creator A5019487756 @default.
- W2912783833 creator A5039661533 @default.
- W2912783833 creator A5049587975 @default.
- W2912783833 creator A5052566599 @default.
- W2912783833 creator A5053817882 @default.
- W2912783833 creator A5062924297 @default.
- W2912783833 creator A5072961170 @default.
- W2912783833 date "2019-05-01" @default.
- W2912783833 modified "2023-09-24" @default.
- W2912783833 title "Elucidation of the mechanism of disulfide exchange between staphylococcal thioredoxin2 and thioredoxin reductase2: A structural insight" @default.
- W2912783833 cites W1504571050 @default.
- W2912783833 cites W1605560583 @default.
- W2912783833 cites W1788190869 @default.
- W2912783833 cites W1841365526 @default.
- W2912783833 cites W1881010148 @default.
- W2912783833 cites W1900378797 @default.
- W2912783833 cites W1918767705 @default.
- W2912783833 cites W1965968697 @default.
- W2912783833 cites W1967650766 @default.
- W2912783833 cites W1969210564 @default.
- W2912783833 cites W1970063045 @default.
- W2912783833 cites W1971624564 @default.
- W2912783833 cites W1977552539 @default.
- W2912783833 cites W1981743332 @default.
- W2912783833 cites W1984697058 @default.
- W2912783833 cites W1986191025 @default.
- W2912783833 cites W1992533564 @default.
- W2912783833 cites W1993466421 @default.
- W2912783833 cites W1996607909 @default.
- W2912783833 cites W1997666539 @default.
- W2912783833 cites W1999759288 @default.
- W2912783833 cites W2008203769 @default.
- W2912783833 cites W2008808040 @default.
- W2912783833 cites W2009757343 @default.
- W2912783833 cites W2014694459 @default.
- W2912783833 cites W2020735633 @default.
- W2912783833 cites W2021741522 @default.
- W2912783833 cites W2026536086 @default.
- W2912783833 cites W2027249579 @default.
- W2912783833 cites W2029684104 @default.
- W2912783833 cites W2042350949 @default.
- W2912783833 cites W2049701513 @default.
- W2912783833 cites W2050575734 @default.
- W2912783833 cites W2051597263 @default.
- W2912783833 cites W2053538195 @default.
- W2912783833 cites W2054417063 @default.
- W2912783833 cites W2060606932 @default.
- W2912783833 cites W2065020384 @default.
- W2912783833 cites W2068861782 @default.
- W2912783833 cites W2069254089 @default.
- W2912783833 cites W2073841855 @default.
- W2912783833 cites W2082467091 @default.
- W2912783833 cites W2082667898 @default.
- W2912783833 cites W2083177889 @default.
- W2912783833 cites W2090943533 @default.
- W2912783833 cites W2097493124 @default.
- W2912783833 cites W2103650142 @default.
- W2912783833 cites W2110076050 @default.
- W2912783833 cites W2111004096 @default.
- W2912783833 cites W2111188921 @default.
- W2912783833 cites W2111507825 @default.
- W2912783833 cites W2123786680 @default.
- W2912783833 cites W2131727615 @default.
- W2912783833 cites W2137430348 @default.
- W2912783833 cites W2144255163 @default.
- W2912783833 cites W2149585271 @default.
- W2912783833 cites W2154748053 @default.
- W2912783833 cites W2156366212 @default.
- W2912783833 cites W2314649741 @default.
- W2912783833 cites W2610847176 @default.
- W2912783833 cites W2800648160 @default.
- W2912783833 cites W2890265603 @default.
- W2912783833 cites W4239041642 @default.
- W2912783833 doi "https://doi.org/10.1016/j.biochi.2019.01.019" @default.
- W2912783833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30710560" @default.
- W2912783833 hasPublicationYear "2019" @default.
- W2912783833 type Work @default.
- W2912783833 sameAs 2912783833 @default.
- W2912783833 citedByCount "1" @default.
- W2912783833 countsByYear W29127838332021 @default.
- W2912783833 crossrefType "journal-article" @default.
- W2912783833 hasAuthorship W2912783833A5019487756 @default.
- W2912783833 hasAuthorship W2912783833A5039661533 @default.
- W2912783833 hasAuthorship W2912783833A5049587975 @default.
- W2912783833 hasAuthorship W2912783833A5052566599 @default.
- W2912783833 hasAuthorship W2912783833A5053817882 @default.
- W2912783833 hasAuthorship W2912783833A5062924297 @default.
- W2912783833 hasAuthorship W2912783833A5072961170 @default.
- W2912783833 hasConcept C132677234 @default.
- W2912783833 hasConcept C178790620 @default.
- W2912783833 hasConcept C181199279 @default.
- W2912783833 hasConcept C185592680 @default.
- W2912783833 hasConcept C190062978 @default.
- W2912783833 hasConcept C2776151105 @default.
- W2912783833 hasConcept C2777737464 @default.
- W2912783833 hasConcept C2779201268 @default.