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- W2912785092 abstract "Nuclear receptors (NRs) are a superfamily of ligand-dependent transcription factors that modulate several biological processes. Traditionally, modulation of NRs has been focused on the development of ligands that recognize and bind to the ligand binding domain (LBD), resulting in activation or repression of transcription through the recruitment of coregulators. However, for more severe diseases, such as breast and prostate cancer, the conventional treatment addressing LBD modulation is not always successful, due to tumor resistance. To overcome these challenges and aiming to modulate NR activity by inhibiting the NR-DNA interaction, new studies focus on the development of molecules targeting alternative sites and domains on NRs. Here, we discuss two different approaches for this alternative NR modulation: one targeting the NR DNA binding domain (DBD); and the other targeting the DNA sites recognized by NRs. Our aim is to present the challenges and perspectives for developing specific inhibitors for each purpose, alongside with already reported examples." @default.
- W2912785092 created "2019-02-21" @default.
- W2912785092 creator A5017715604 @default.
- W2912785092 creator A5025844773 @default.
- W2912785092 creator A5028243921 @default.
- W2912785092 creator A5040686983 @default.
- W2912785092 creator A5051794350 @default.
- W2912785092 creator A5068776043 @default.
- W2912785092 creator A5090309176 @default.
- W2912785092 date "2019-03-01" @default.
- W2912785092 modified "2023-10-18" @default.
- W2912785092 title "Modulation of nuclear receptor function: Targeting the protein-DNA interface" @default.
- W2912785092 cites W1537737183 @default.
- W2912785092 cites W1545280767 @default.
- W2912785092 cites W1547975753 @default.
- W2912785092 cites W1577245844 @default.
- W2912785092 cites W1592075643 @default.
- W2912785092 cites W1703081596 @default.
- W2912785092 cites W1940404995 @default.
- W2912785092 cites W1968937305 @default.
- W2912785092 cites W1976263202 @default.
- W2912785092 cites W1983057459 @default.
- W2912785092 cites W1985865142 @default.
- W2912785092 cites W1987040411 @default.
- W2912785092 cites W1987173739 @default.
- W2912785092 cites W1989121880 @default.
- W2912785092 cites W1989701451 @default.
- W2912785092 cites W1999143684 @default.
- W2912785092 cites W2000975094 @default.
- W2912785092 cites W2002931771 @default.
- W2912785092 cites W2005374212 @default.
- W2912785092 cites W2011158289 @default.
- W2912785092 cites W2011216058 @default.
- W2912785092 cites W2011467252 @default.
- W2912785092 cites W2013378362 @default.
- W2912785092 cites W2013600324 @default.
- W2912785092 cites W2014207892 @default.
- W2912785092 cites W2015497140 @default.
- W2912785092 cites W2015830320 @default.
- W2912785092 cites W2016964184 @default.
- W2912785092 cites W2017206515 @default.
- W2912785092 cites W2017764099 @default.
- W2912785092 cites W2018902871 @default.
- W2912785092 cites W2019498797 @default.
- W2912785092 cites W2019503711 @default.
- W2912785092 cites W2020438953 @default.
- W2912785092 cites W2020952430 @default.
- W2912785092 cites W2021429928 @default.
- W2912785092 cites W2021758696 @default.
- W2912785092 cites W2021934422 @default.
- W2912785092 cites W2023077979 @default.
- W2912785092 cites W2024180698 @default.
- W2912785092 cites W2025155497 @default.
- W2912785092 cites W2026298200 @default.
- W2912785092 cites W2030129448 @default.
- W2912785092 cites W2030702360 @default.
- W2912785092 cites W2032129833 @default.
- W2912785092 cites W2033965812 @default.
- W2912785092 cites W2034105964 @default.
- W2912785092 cites W2035749983 @default.
- W2912785092 cites W2037932659 @default.
- W2912785092 cites W2038114355 @default.
- W2912785092 cites W2038586333 @default.
- W2912785092 cites W2041781038 @default.
- W2912785092 cites W2044203168 @default.
- W2912785092 cites W2046289217 @default.
- W2912785092 cites W2048327622 @default.
- W2912785092 cites W2051974074 @default.
- W2912785092 cites W205313094 @default.
- W2912785092 cites W2053273553 @default.
- W2912785092 cites W2054114642 @default.
- W2912785092 cites W2056104022 @default.
- W2912785092 cites W2056534691 @default.
- W2912785092 cites W2056603207 @default.
- W2912785092 cites W2056671340 @default.
- W2912785092 cites W2059792018 @default.
- W2912785092 cites W2060903877 @default.
- W2912785092 cites W2063110155 @default.
- W2912785092 cites W2063777385 @default.
- W2912785092 cites W2064208521 @default.
- W2912785092 cites W2066385821 @default.
- W2912785092 cites W2073746700 @default.
- W2912785092 cites W2073786155 @default.
- W2912785092 cites W2074595922 @default.
- W2912785092 cites W2075495560 @default.
- W2912785092 cites W2075922536 @default.
- W2912785092 cites W2077699915 @default.
- W2912785092 cites W2077854579 @default.
- W2912785092 cites W2078095448 @default.
- W2912785092 cites W2078537140 @default.
- W2912785092 cites W2080748037 @default.
- W2912785092 cites W2082221765 @default.
- W2912785092 cites W2085820867 @default.
- W2912785092 cites W2090190311 @default.
- W2912785092 cites W2092869314 @default.
- W2912785092 cites W2093930291 @default.
- W2912785092 cites W2098315968 @default.
- W2912785092 cites W2105259330 @default.