FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912786687> ?p ?o ?g. }

• W2912786687 endingPage "506" @default.
• W2912786687 startingPage "497" @default.
• W2912786687 abstract "Background FVC may underestimate the slow vital capacity (SVC) due to early closure of the small airways at low lung volumes in the forced maneuver. It remains unclear whether using SVC instead of FVC in the FEV1/vital capacity (VC) ratio increases the yield of spirometry in detecting airflow limitation or, alternatively, leads to a false-positive finding for obstruction. Methods This study included 13,893 adult outpatients with FEV1/FVC and total lung capacity at or above the lower limit of normal. A cluster of clinical and physiological variables defined the probability of airway disease and dysfunction, respectively. Results The prevalence of “discordance” (preserved FEV1/FVC but low FEV1/SVC) was 20.4%: discordant subjects had lower mid-expiratory flows, higher airway resistance, worse gas trapping, and ventilation distribution abnormalities than “concordant” subjects (both ratios preserved) (P < .05). Regardless of sex, age < 60 years, BMI > 30 kg/m2, and FEV1 > 70% predicted were associated with discordance (P < .001). Discordant subjects with preserved FEV1/FVC but low FEV1/SVC were four times more likely to be diagnosed with an obstructive airway disease by a respirologist compared with those with preserved FEV1/SVC and FEV1/FVC. The only exception was in the elderly subgroup with discordance (age > 70 years): only 10% of these subjects were subsequently diagnosed with an airway disease (P > .05). Conclusions Using SVC instead of FVC in the FEV1/VC ratio enhances the yield of spirometry in detecting mild airflow obstruction in younger and obese subjects. The FEV1/SVC ratio, however, should be used with caution in elderly subjects with preserved FEV1/FVC because a low value may represent a false-positive finding for airflow limitation. FVC may underestimate the slow vital capacity (SVC) due to early closure of the small airways at low lung volumes in the forced maneuver. It remains unclear whether using SVC instead of FVC in the FEV1/vital capacity (VC) ratio increases the yield of spirometry in detecting airflow limitation or, alternatively, leads to a false-positive finding for obstruction. This study included 13,893 adult outpatients with FEV1/FVC and total lung capacity at or above the lower limit of normal. A cluster of clinical and physiological variables defined the probability of airway disease and dysfunction, respectively. The prevalence of “discordance” (preserved FEV1/FVC but low FEV1/SVC) was 20.4%: discordant subjects had lower mid-expiratory flows, higher airway resistance, worse gas trapping, and ventilation distribution abnormalities than “concordant” subjects (both ratios preserved) (P < .05). Regardless of sex, age < 60 years, BMI > 30 kg/m2, and FEV1 > 70% predicted were associated with discordance (P < .001). Discordant subjects with preserved FEV1/FVC but low FEV1/SVC were four times more likely to be diagnosed with an obstructive airway disease by a respirologist compared with those with preserved FEV1/SVC and FEV1/FVC. The only exception was in the elderly subgroup with discordance (age > 70 years): only 10% of these subjects were subsequently diagnosed with an airway disease (P > .05). Using SVC instead of FVC in the FEV1/VC ratio enhances the yield of spirometry in detecting mild airflow obstruction in younger and obese subjects. The FEV1/SVC ratio, however, should be used with caution in elderly subjects with preserved FEV1/FVC because a low value may represent a false-positive finding for airflow limitation." @default.
• W2912786687 created "2019-02-21" @default.
• W2912786687 creator A5003608061 @default.
• W2912786687 creator A5017051373 @default.
• W2912786687 creator A5024420357 @default.
• W2912786687 creator A5037474136 @default.
• W2912786687 creator A5038589727 @default.
• W2912786687 creator A5042406176 @default.
• W2912786687 creator A5045798052 @default.
• W2912786687 creator A5057122393 @default.
• W2912786687 creator A5059541894 @default.
• W2912786687 date "2019-09-01" @default.
• W2912786687 modified "2023-10-18" @default.
• W2912786687 title "Is the Slow Vital Capacity Clinically Useful to Uncover Airflow Limitation in Subjects With Preserved FEV1/FVC Ratio?" @default.
• W2912786687 cites W1837996906 @default.
• W2912786687 cites W1872864410 @default.
• W2912786687 cites W1899002956 @default.
• W2912786687 cites W1939202796 @default.
• W2912786687 cites W1970648849 @default.
• W2912786687 cites W1976035297 @default.
• W2912786687 cites W1985643930 @default.
• W2912786687 cites W2008520243 @default.
• W2912786687 cites W2028868921 @default.
• W2912786687 cites W2091130802 @default.
• W2912786687 cites W2093149211 @default.
• W2912786687 cites W2098371272 @default.
• W2912786687 cites W2099449365 @default.
• W2912786687 cites W2100489018 @default.
• W2912786687 cites W2102987452 @default.
• W2912786687 cites W2103276330 @default.
• W2912786687 cites W2105244655 @default.
• W2912786687 cites W2109964403 @default.
• W2912786687 cites W2124879124 @default.
• W2912786687 cites W2125078269 @default.
• W2912786687 cites W2133782115 @default.
• W2912786687 cites W2139332976 @default.
• W2912786687 cites W2145153937 @default.
• W2912786687 cites W2162884981 @default.
• W2912786687 cites W2167150407 @default.
• W2912786687 cites W2170757541 @default.
• W2912786687 cites W2197672626 @default.
• W2912786687 cites W2202739765 @default.
• W2912786687 cites W2253855598 @default.
• W2912786687 cites W2258808760 @default.
• W2912786687 cites W2285998431 @default.
• W2912786687 cites W2338788949 @default.
• W2912786687 cites W2346589647 @default.
• W2912786687 cites W2490752710 @default.
• W2912786687 cites W2619360243 @default.
• W2912786687 cites W2769802445 @default.
• W2912786687 cites W2773101042 @default.
• W2912786687 cites W2898753907 @default.
• W2912786687 cites W4233094824 @default.
• W2912786687 cites W72268806 @default.
• W2912786687 doi "https://doi.org/10.1016/j.chest.2019.02.001" @default.
• W2912786687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30768928" @default.
• W2912786687 hasPublicationYear "2019" @default.
• W2912786687 type Work @default.
• W2912786687 sameAs 2912786687 @default.
• W2912786687 citedByCount "20" @default.
• W2912786687 countsByYear W29127866872019 @default.
• W2912786687 countsByYear W29127866872020 @default.
• W2912786687 countsByYear W29127866872021 @default.
• W2912786687 countsByYear W29127866872022 @default.
• W2912786687 countsByYear W29127866872023 @default.
• W2912786687 crossrefType "journal-article" @default.
• W2912786687 hasAuthorship W2912786687A5003608061 @default.
• W2912786687 hasAuthorship W2912786687A5017051373 @default.
• W2912786687 hasAuthorship W2912786687A5024420357 @default.
• W2912786687 hasAuthorship W2912786687A5037474136 @default.
• W2912786687 hasAuthorship W2912786687A5038589727 @default.
• W2912786687 hasAuthorship W2912786687A5042406176 @default.
• W2912786687 hasAuthorship W2912786687A5045798052 @default.
• W2912786687 hasAuthorship W2912786687A5057122393 @default.
• W2912786687 hasAuthorship W2912786687A5059541894 @default.
• W2912786687 hasConcept C105922876 @default.
• W2912786687 hasConcept C126322002 @default.
• W2912786687 hasConcept C127413603 @default.
• W2912786687 hasConcept C164705383 @default.
• W2912786687 hasConcept C165637977 @default.
• W2912786687 hasConcept C200457457 @default.
• W2912786687 hasConcept C2776042228 @default.
• W2912786687 hasConcept C2777223847 @default.
• W2912786687 hasConcept C2777714996 @default.
• W2912786687 hasConcept C2778333281 @default.
• W2912786687 hasConcept C2780333948 @default.
• W2912786687 hasConcept C3018587741 @default.
• W2912786687 hasConcept C33362165 @default.
• W2912786687 hasConcept C42219234 @default.
• W2912786687 hasConcept C55520419 @default.
• W2912786687 hasConcept C71924100 @default.
• W2912786687 hasConcept C75603125 @default.
• W2912786687 hasConcept C78519656 @default.
• W2912786687 hasConceptScore W2912786687C105922876 @default.
• W2912786687 hasConceptScore W2912786687C126322002 @default.
• W2912786687 hasConceptScore W2912786687C127413603 @default.
• W2912786687 hasConceptScore W2912786687C164705383 @default.
• W2912786687 hasConceptScore W2912786687C165637977 @default.

• next