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• W2912787902 abstract "In all living organisms, genome replication is essential for their development and maintenance. In the genome of simple organisms, such as bacteria and small eukaryotic deoxyribonucleic acid (DNA) viruses, DNA replication starts from a well-characterised single origin. In complex eukaryotes, such as metazoans, DNA replication starts from dozens of thousands of origins spread along the different chromosomes. This high number of origins, together with the technical problems encountered in finding reliable methods for their large-scale mapping, made difficult their characterisation. However, owing to the new genome-wide approaches developed in the past few years, we have now a better understanding of how replication origins are established in higher eukaryotes. These studies have shown an intrinsic correlation between replication origins and other genome features, such as gene transcription and epigenetic regulation, and revealed an amazing flexibility in their usage.Key Concepts: Replication origins are defined by specific DNA sequences in bacteria, viruses and Saccharomyces cerevisiae, but not in Schizosaccharomyces pombe and metazoans.DNA replication origins are activated in a defined temporal order, called timing of DNA replication.DNA replication origins are flexible: only a subset of them is activated at each cell cycle.DNA replication takes place at specific subnuclear structures, called replication foci.The number and position of replication origins to be activated may vary according to the developmental or growing conditions.Keywords:DNA replication;chromatin;epigenetic;transcription;development" @default.
• W2912787902 created "2019-02-21" @default.
• W2912787902 creator A5013737080 @default.
• W2912787902 creator A5051934476 @default.
• W2912787902 date "2014-08-15" @default.
• W2912787902 modified "2023-09-25" @default.
• W2912787902 title "DNA Replication Origins" @default.
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• W2912787902 doi "https://doi.org/10.1002/9780470015902.a0006170.pub2" @default.
• W2912787902 hasPublicationYear "2014" @default.
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