FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912790334> ?p ?o ?g. }

• W2912790334 endingPage "311" @default.
• W2912790334 startingPage "311" @default.
• W2912790334 abstract "It has now been over 60 years since U.S. nuclear testing was conducted in the Pacific islands and Nevada, exposing military personnel to varying levels of ionizing radiation. Actual doses are not well-established, as film badges in the 1950s had many limitations. We sought a means of independently assessing dose for comparison with historical film badge records and dose reconstruction conducted in parallel. For the purpose of quantitative retrospective biodosimetry, peripheral blood samples from 12 exposed veterans and 12 age-matched (>80 years) veteran controls were collected and evaluated for radiation-induced chromosome damage utilizing directional genomic hybridization (dGH), a cytogenomics-based methodology that facilitates simultaneous detection of translocations and inversions. Standard calibration curves were constructed from six male volunteers in their mid-20s to reflect the age range of the veterans at time of exposure. Doses were estimated for each veteran using translocation and inversion rates independently; however, combining them by a weighted-average generally improved the accuracy of dose estimations. Various confounding factors were also evaluated for potential effects on chromosome aberration frequencies. Perhaps not surprisingly, smoking and age-associated increases in background frequencies of inversions were observed. Telomere length was also measured, and inverse relationships with both age and combined weighted dose estimates were observed. Interestingly, smokers in the non-exposed control veteran cohort displayed similar telomere lengths as those in the never-smoker exposed veteran group, suggesting that chronic smoking had as much effect on telomere length as a single exposure to radioactive fallout. Taken together, we find that our approach of combined chromosome aberration-based retrospective biodosimetry provided reliable dose estimation capability, particularly on a group average basis, for exposures above statistical detection limits." @default.
• W2912790334 created "2019-02-21" @default.
• W2912790334 creator A5021251025 @default.
• W2912790334 creator A5041018139 @default.
• W2912790334 creator A5043044040 @default.
• W2912790334 creator A5044744564 @default.
• W2912790334 creator A5048752550 @default.
• W2912790334 creator A5069515220 @default.
• W2912790334 creator A5083181792 @default.
• W2912790334 date "2019-02-04" @default.
• W2912790334 modified "2023-10-17" @default.
• W2912790334 title "Chromosome Translocations, Inversions and Telomere Length for Retrospective Biodosimetry on Exposed U.S. Atomic Veterans" @default.
• W2912790334 cites W1538980175 @default.
• W2912790334 cites W1551292370 @default.
• W2912790334 cites W1963691994 @default.
• W2912790334 cites W1968808595 @default.
• W2912790334 cites W1973677817 @default.
• W2912790334 cites W1974259398 @default.
• W2912790334 cites W1975998096 @default.
• W2912790334 cites W1983490683 @default.
• W2912790334 cites W1988648535 @default.
• W2912790334 cites W1994873752 @default.
• W2912790334 cites W2018110745 @default.
• W2912790334 cites W2019480121 @default.
• W2912790334 cites W2025156606 @default.
• W2912790334 cites W2026761826 @default.
• W2912790334 cites W2030191595 @default.
• W2912790334 cites W2036639619 @default.
• W2912790334 cites W2037503572 @default.
• W2912790334 cites W2039128321 @default.
• W2912790334 cites W2040444593 @default.
• W2912790334 cites W2042518322 @default.
• W2912790334 cites W2061625728 @default.
• W2912790334 cites W2096712048 @default.
• W2912790334 cites W2098085059 @default.
• W2912790334 cites W2102910849 @default.
• W2912790334 cites W2111140691 @default.
• W2912790334 cites W2114284647 @default.
• W2912790334 cites W2114547427 @default.
• W2912790334 cites W2115414537 @default.
• W2912790334 cites W2119690634 @default.
• W2912790334 cites W2147991226 @default.
• W2912790334 cites W2148468748 @default.
• W2912790334 cites W2152947695 @default.
• W2912790334 cites W2158479120 @default.
• W2912790334 cites W2160494581 @default.
• W2912790334 cites W2167659390 @default.
• W2912790334 cites W2218907825 @default.
• W2912790334 cites W2302928704 @default.
• W2912790334 cites W2307997512 @default.
• W2912790334 cites W2329016634 @default.
• W2912790334 cites W2339525891 @default.
• W2912790334 cites W2414296945 @default.
• W2912790334 cites W2464199698 @default.
• W2912790334 cites W2520931435 @default.
• W2912790334 cites W2581452879 @default.
• W2912790334 cites W2585851141 @default.
• W2912790334 cites W2802488885 @default.
• W2912790334 cites W2915756657 @default.
• W2912790334 cites W2955606922 @default.
• W2912790334 cites W4214894679 @default.
• W2912790334 cites W4239629003 @default.
• W2912790334 cites W4240426651 @default.
• W2912790334 cites W2219254211 @default.
• W2912790334 doi "https://doi.org/10.1667/rr15240.1" @default.
• W2912790334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6492561" @default.
• W2912790334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30714852" @default.
• W2912790334 hasPublicationYear "2019" @default.
• W2912790334 type Work @default.
• W2912790334 sameAs 2912790334 @default.
• W2912790334 citedByCount "23" @default.
• W2912790334 countsByYear W29127903342019 @default.
• W2912790334 countsByYear W29127903342020 @default.
• W2912790334 countsByYear W29127903342021 @default.
• W2912790334 countsByYear W29127903342022 @default.
• W2912790334 countsByYear W29127903342023 @default.
• W2912790334 crossrefType "journal-article" @default.
• W2912790334 hasAuthorship W2912790334A5021251025 @default.
• W2912790334 hasAuthorship W2912790334A5041018139 @default.
• W2912790334 hasAuthorship W2912790334A5043044040 @default.
• W2912790334 hasAuthorship W2912790334A5044744564 @default.
• W2912790334 hasAuthorship W2912790334A5048752550 @default.
• W2912790334 hasAuthorship W2912790334A5069515220 @default.
• W2912790334 hasAuthorship W2912790334A5083181792 @default.
• W2912790334 hasBestOaLocation W29127903341 @default.
• W2912790334 hasConcept C104317684 @default.
• W2912790334 hasConcept C111337013 @default.
• W2912790334 hasConcept C121332964 @default.
• W2912790334 hasConcept C126322002 @default.
• W2912790334 hasConcept C138626823 @default.
• W2912790334 hasConcept C144024400 @default.
• W2912790334 hasConcept C149923435 @default.
• W2912790334 hasConcept C167135981 @default.
• W2912790334 hasConcept C177336024 @default.
• W2912790334 hasConcept C18231593 @default.
• W2912790334 hasConcept C185544564 @default.
• W2912790334 hasConcept C2779254040 @default.
• W2912790334 hasConcept C2989005 @default.

• next