FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912791774> ?p ?o ?g. }

• W2912791774 endingPage "34" @default.
• W2912791774 startingPage "23" @default.
• W2912791774 abstract "This study aimed to evaluate female adult offspring induced by prenatal caffeine exposure (PCE) are susceptible to non-alcoholic fatty liver disease (NAFLD) and to explore the underlying programming mechanisms. Pregnant rats were intragastrically administered caffeine (30, 60, and 120 mg/kg.d) on gestational day (GD) 9-20. The female adult offspring were randomly divided into three groups: offspring without or with chronic stress during postnatal week (PW) 10-12 and PW28 offspring. Results showed that PW28 PCE female offspring had a higher hepatic triglyceride content and Kleiner scores, accompanied by elevated serum corticosterone levels. Moreover, the expression levels of hepatic glucocorticoid receptor (GR), CCAAT enhancer binding protein α (C/EBPα), fatty acid synthetase (FASN) and the transcription factor-sterol regulatory element binding protein 1c (SREBP1c) were increased, but SIRT1 expression was decreased. The fetal rats and PW12 offspring with chronic stress exhibited similar changes as PW28 offspring, accompanied by increased levels of H3K14ac and H3K27ac in the SREBP1c and FASN gene promoters. These effects were also observed by treating L02 cells with cortisol and were partially reversed by GR or C/EBPα siRNA or treatment with the SIRT1 agonist resveratrol. Taken together, PCE-induced high glucocorticoids levels enhanced histone modifications and expression of SREBP1c and FASN via activation of the GR-C/EBPα-SIRT1 pathway in utero. This enhanced female fetal hepatic triglyceride synthesis and continued throughout postnatal and adult life, increasing the susceptibility to adult NAFLD." @default.
• W2912791774 created "2019-02-21" @default.
• W2912791774 creator A5011504904 @default.
• W2912791774 creator A5012990002 @default.
• W2912791774 creator A5022703297 @default.
• W2912791774 creator A5056739581 @default.
• W2912791774 creator A5073469158 @default.
• W2912791774 creator A5089787155 @default.
• W2912791774 creator A5090366405 @default.
• W2912791774 date "2019-04-01" @default.
• W2912791774 modified "2023-10-17" @default.
• W2912791774 title "Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathway" @default.
• W2912791774 cites W100734209 @default.
• W2912791774 cites W1622799587 @default.
• W2912791774 cites W1832948997 @default.
• W2912791774 cites W1935135811 @default.
• W2912791774 cites W1949149477 @default.
• W2912791774 cites W1969734540 @default.
• W2912791774 cites W1973331045 @default.
• W2912791774 cites W1973916444 @default.
• W2912791774 cites W1975219018 @default.
• W2912791774 cites W1975462549 @default.
• W2912791774 cites W1978897662 @default.
• W2912791774 cites W1992860556 @default.
• W2912791774 cites W1996620282 @default.
• W2912791774 cites W2001993336 @default.
• W2912791774 cites W2002349285 @default.
• W2912791774 cites W2005645716 @default.
• W2912791774 cites W2005946530 @default.
• W2912791774 cites W2014668126 @default.
• W2912791774 cites W2015773627 @default.
• W2912791774 cites W2016541943 @default.
• W2912791774 cites W2023253489 @default.
• W2912791774 cites W2034836489 @default.
• W2912791774 cites W2035190750 @default.
• W2912791774 cites W2040849068 @default.
• W2912791774 cites W2041513185 @default.
• W2912791774 cites W2044920828 @default.
• W2912791774 cites W2047996813 @default.
• W2912791774 cites W2057348326 @default.
• W2912791774 cites W2057720991 @default.
• W2912791774 cites W2058314819 @default.
• W2912791774 cites W2061242273 @default.
• W2912791774 cites W2067181732 @default.
• W2912791774 cites W2067740038 @default.
• W2912791774 cites W2070586971 @default.
• W2912791774 cites W2076706977 @default.
• W2912791774 cites W2088522484 @default.
• W2912791774 cites W2090917476 @default.
• W2912791774 cites W2093250184 @default.
• W2912791774 cites W2093944219 @default.
• W2912791774 cites W2095640847 @default.
• W2912791774 cites W2096304911 @default.
• W2912791774 cites W2096726007 @default.
• W2912791774 cites W2097775881 @default.
• W2912791774 cites W2099002898 @default.
• W2912791774 cites W2100680516 @default.
• W2912791774 cites W2103853915 @default.
• W2912791774 cites W2114243980 @default.
• W2912791774 cites W2121836743 @default.
• W2912791774 cites W2125855766 @default.
• W2912791774 cites W2131256997 @default.
• W2912791774 cites W2149342673 @default.
• W2912791774 cites W2153113593 @default.
• W2912791774 cites W2168570093 @default.
• W2912791774 cites W2300296320 @default.
• W2912791774 cites W2338061389 @default.
• W2912791774 cites W2461760410 @default.
• W2912791774 doi "https://doi.org/10.1016/j.tox.2019.02.008" @default.
• W2912791774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30776459" @default.
• W2912791774 hasPublicationYear "2019" @default.
• W2912791774 type Work @default.
• W2912791774 sameAs 2912791774 @default.
• W2912791774 citedByCount "23" @default.
• W2912791774 countsByYear W29127917742019 @default.
• W2912791774 countsByYear W29127917742020 @default.
• W2912791774 countsByYear W29127917742021 @default.
• W2912791774 countsByYear W29127917742022 @default.
• W2912791774 countsByYear W29127917742023 @default.
• W2912791774 crossrefType "journal-article" @default.
• W2912791774 hasAuthorship W2912791774A5011504904 @default.
• W2912791774 hasAuthorship W2912791774A5012990002 @default.
• W2912791774 hasAuthorship W2912791774A5022703297 @default.
• W2912791774 hasAuthorship W2912791774A5056739581 @default.
• W2912791774 hasAuthorship W2912791774A5073469158 @default.
• W2912791774 hasAuthorship W2912791774A5089787155 @default.
• W2912791774 hasAuthorship W2912791774A5090366405 @default.
• W2912791774 hasConcept C104317684 @default.
• W2912791774 hasConcept C112672928 @default.
• W2912791774 hasConcept C126322002 @default.
• W2912791774 hasConcept C127561419 @default.
• W2912791774 hasConcept C134018914 @default.
• W2912791774 hasConcept C149240914 @default.
• W2912791774 hasConcept C2776536020 @default.
• W2912791774 hasConcept C2778163477 @default.
• W2912791774 hasConcept C2778772119 @default.
• W2912791774 hasConcept C2778913445 @default.
• W2912791774 hasConcept C2779134260 @default.

• next