Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912793959> ?p ?o ?g. }
- W2912793959 endingPage "183.e4" @default.
- W2912793959 startingPage "173" @default.
- W2912793959 abstract "Co-release of multiple neurotransmitters from secretory vesicles is common in neurons and neuroendocrine cells. However, whether and how the transmitters co-released from a single vesicle are differentially regulated remains unknown. In matrix-containing dense-core vesicles (DCVs) in chromaffin cells, there are two modes of catecholamine (CA) release from a single DCV: quantal and sub-quantal. By combining two microelectrodes to simultaneously record co-release of the native CA and ATP from a DCV, we report that (1) CA and ATP were co-released during a DCV fusion; (2) during kiss-and-run (KAR) fusion, the co-released CA was sub-quantal, whereas the co-released ATP was quantal; and (3) knockdown and knockout of the DCV matrix led to quantal co-release of both CA and ATP even in KAR mode. These findings strongly imply that, in contrast to sub-quantal CA release in chromaffin cells, fast synaptic transmission without transmitter-matrix binding is mediated exclusively via quantal release in neurons." @default.
- W2912793959 created "2019-02-21" @default.
- W2912793959 creator A5004532333 @default.
- W2912793959 creator A5006499543 @default.
- W2912793959 creator A5011877804 @default.
- W2912793959 creator A5012278873 @default.
- W2912793959 creator A5014528965 @default.
- W2912793959 creator A5016834811 @default.
- W2912793959 creator A5017774638 @default.
- W2912793959 creator A5026607823 @default.
- W2912793959 creator A5030001749 @default.
- W2912793959 creator A5034211965 @default.
- W2912793959 creator A5035020883 @default.
- W2912793959 creator A5047622083 @default.
- W2912793959 creator A5048826252 @default.
- W2912793959 creator A5052997826 @default.
- W2912793959 creator A5053146746 @default.
- W2912793959 creator A5058003036 @default.
- W2912793959 creator A5062109496 @default.
- W2912793959 creator A5065447668 @default.
- W2912793959 creator A5071462700 @default.
- W2912793959 creator A5077437592 @default.
- W2912793959 creator A5081266476 @default.
- W2912793959 creator A5086071359 @default.
- W2912793959 creator A5087984896 @default.
- W2912793959 creator A5091127487 @default.
- W2912793959 date "2019-04-01" @default.
- W2912793959 modified "2023-10-16" @default.
- W2912793959 title "Differential Co-release of Two Neurotransmitters from a Vesicle Fusion Pore in Mammalian Adrenal Chromaffin Cells" @default.
- W2912793959 cites W1495115482 @default.
- W2912793959 cites W1509155252 @default.
- W2912793959 cites W1516351120 @default.
- W2912793959 cites W1564650596 @default.
- W2912793959 cites W1599906730 @default.
- W2912793959 cites W1959592693 @default.
- W2912793959 cites W1970654974 @default.
- W2912793959 cites W1974807815 @default.
- W2912793959 cites W1995327626 @default.
- W2912793959 cites W1995831908 @default.
- W2912793959 cites W2006766519 @default.
- W2912793959 cites W2013163569 @default.
- W2912793959 cites W2018493611 @default.
- W2912793959 cites W2025192851 @default.
- W2912793959 cites W2026175547 @default.
- W2912793959 cites W2026224491 @default.
- W2912793959 cites W2032882224 @default.
- W2912793959 cites W2033067408 @default.
- W2912793959 cites W2033797809 @default.
- W2912793959 cites W2049279140 @default.
- W2912793959 cites W2050427247 @default.
- W2912793959 cites W2051540336 @default.
- W2912793959 cites W2053635222 @default.
- W2912793959 cites W2060384627 @default.
- W2912793959 cites W2062007562 @default.
- W2912793959 cites W2062254454 @default.
- W2912793959 cites W2064037757 @default.
- W2912793959 cites W2065171944 @default.
- W2912793959 cites W2068614699 @default.
- W2912793959 cites W2073223918 @default.
- W2912793959 cites W2077644186 @default.
- W2912793959 cites W2078233092 @default.
- W2912793959 cites W2080954023 @default.
- W2912793959 cites W2084935073 @default.
- W2912793959 cites W2093411259 @default.
- W2912793959 cites W2093893801 @default.
- W2912793959 cites W2095352259 @default.
- W2912793959 cites W2095795382 @default.
- W2912793959 cites W2098635427 @default.
- W2912793959 cites W2099298311 @default.
- W2912793959 cites W2099348078 @default.
- W2912793959 cites W2102289204 @default.
- W2912793959 cites W2103480378 @default.
- W2912793959 cites W2103829969 @default.
- W2912793959 cites W2119825883 @default.
- W2912793959 cites W2131653836 @default.
- W2912793959 cites W2134246284 @default.
- W2912793959 cites W2136916973 @default.
- W2912793959 cites W2137229430 @default.
- W2912793959 cites W2137639709 @default.
- W2912793959 cites W2144602724 @default.
- W2912793959 cites W2147123722 @default.
- W2912793959 cites W2156346381 @default.
- W2912793959 cites W2171276368 @default.
- W2912793959 cites W2175379445 @default.
- W2912793959 cites W2206878032 @default.
- W2912793959 cites W2273032085 @default.
- W2912793959 cites W2412448667 @default.
- W2912793959 cites W2471779620 @default.
- W2912793959 cites W2560490590 @default.
- W2912793959 cites W2665388685 @default.
- W2912793959 cites W2804398529 @default.
- W2912793959 cites W2899330613 @default.
- W2912793959 doi "https://doi.org/10.1016/j.neuron.2019.01.031" @default.
- W2912793959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30773347" @default.
- W2912793959 hasPublicationYear "2019" @default.
- W2912793959 type Work @default.
- W2912793959 sameAs 2912793959 @default.
- W2912793959 citedByCount "23" @default.