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• W2912794152 abstract "Traumatic brain injury (TBI) is a major cause of death and disability. Despite its importance in public health, there are presently no drugs to treat TBI. Many reasons underlie why drugs have failed clinical trials, one reason is that most drugs to treat TBI lose much of their efficacy before patients are first treated. This review discusses the importance of therapeutic time window; the time interval between TBI onset and the initiation of treatment. Therapeutic time window is complex, as brain injury is both acute and chronic, resulting in multiple drug targets that appear and disappear with differing kinetics. The speed and increasing complexity of TBI pathophysiology is a major reason why drugs lose efficacy as time to first dose increases. Recent Phase III clinical trials treated moderate to severe TBI patients within 4-8 h after injury, yet they turned away many potential patients who could not be treated within these time windows. Additionally, most head trauma is mild TBI. Unlike moderate to severe TBI, patients with mild TBI often delay treatment until their symptoms do not abate. Thus, drugs to treat moderate to severe TBI likely will need to retain high efficacy for up to 12 h after injury; drugs for mild TBI, however, will likely need even longer windows. Early pathological events following TBI progress with similar kinetics in humans and animal TBI models suggesting that preclinical testing of time windows assists the design of clinical trials. We reviewed preclinical studies of drugs first dosed later than 4 h after injury. This review showed that therapeutic time window can differ depending upon the animal TBI model and the outcome measure. We identify the few drugs (methamphetamine, melanocortin, minocycline plus N-acetylcysteine, and cycloserine) that demonstrated good therapeutic windows with multiple outcome measures. On the basis of their therapeutic window, these drugs appear to be excellent candidates for clinical trials. In addition to further testing of these drugs, we recommend that the assessment of therapeutic time window with multiple outcome measures becomes a standard component of preclinical drug testing." @default.
• W2912794152 created "2019-02-21" @default.
• W2912794152 creator A5014747796 @default.
• W2912794152 creator A5042964402 @default.
• W2912794152 creator A5084927815 @default.
• W2912794152 date "2019-01-23" @default.
• W2912794152 modified "2023-10-15" @default.
• W2912794152 title "The Importance of Therapeutic Time Window in the Treatment of Traumatic Brain Injury" @default.
• W2912794152 cites W1481990397 @default.
• W2912794152 cites W1484924488 @default.
• W2912794152 cites W1656784884 @default.
• W2912794152 cites W1696600175 @default.
• W2912794152 cites W1966957009 @default.
• W2912794152 cites W1975564029 @default.
• W2912794152 cites W1975967449 @default.
• W2912794152 cites W1977860019 @default.
• W2912794152 cites W1982466286 @default.
• W2912794152 cites W1983080331 @default.
• W2912794152 cites W1983449280 @default.
• W2912794152 cites W1988136368 @default.
• W2912794152 cites W1988775531 @default.
• W2912794152 cites W1994543523 @default.
• W2912794152 cites W1995395034 @default.
• W2912794152 cites W2000047585 @default.
• W2912794152 cites W2003760083 @default.
• W2912794152 cites W2006001085 @default.
• W2912794152 cites W2016191328 @default.
• W2912794152 cites W2016785381 @default.
• W2912794152 cites W2017810165 @default.
• W2912794152 cites W2026134783 @default.
• W2912794152 cites W2030307864 @default.
• W2912794152 cites W2030796131 @default.
• W2912794152 cites W2032951220 @default.
• W2912794152 cites W2041360024 @default.
• W2912794152 cites W2041590252 @default.
• W2912794152 cites W2046037876 @default.
• W2912794152 cites W2050083020 @default.
• W2912794152 cites W2059648396 @default.
• W2912794152 cites W2066881685 @default.
• W2912794152 cites W2068718608 @default.
• W2912794152 cites W2069024481 @default.
• W2912794152 cites W2069977365 @default.
• W2912794152 cites W2071425128 @default.
• W2912794152 cites W2071550630 @default.
• W2912794152 cites W2072514378 @default.
• W2912794152 cites W2073595496 @default.
• W2912794152 cites W2079650445 @default.
• W2912794152 cites W2082186444 @default.
• W2912794152 cites W2085360535 @default.
• W2912794152 cites W2089465514 @default.
• W2912794152 cites W2092104644 @default.
• W2912794152 cites W2094591031 @default.
• W2912794152 cites W2095764747 @default.
• W2912794152 cites W2099972916 @default.
• W2912794152 cites W2116560770 @default.
• W2912794152 cites W2133327433 @default.
• W2912794152 cites W2133961780 @default.
• W2912794152 cites W2137065903 @default.
• W2912794152 cites W2146818063 @default.
• W2912794152 cites W2150445605 @default.
• W2912794152 cites W2150827331 @default.
• W2912794152 cites W2153506838 @default.
• W2912794152 cites W2166531273 @default.
• W2912794152 cites W2166951712 @default.
• W2912794152 cites W2169076855 @default.
• W2912794152 cites W2297621391 @default.
• W2912794152 cites W2316762748 @default.
• W2912794152 cites W2319228377 @default.
• W2912794152 cites W2336019167 @default.
• W2912794152 cites W2462521170 @default.
• W2912794152 cites W2523316909 @default.
• W2912794152 cites W2559848308 @default.
• W2912794152 cites W2591892665 @default.
• W2912794152 cites W2598068240 @default.
• W2912794152 cites W2602999961 @default.
• W2912794152 cites W2612282276 @default.
• W2912794152 cites W2706981686 @default.
• W2912794152 cites W2725760062 @default.
• W2912794152 cites W2754208804 @default.
• W2912794152 cites W2766347735 @default.
• W2912794152 cites W2770793072 @default.
• W2912794152 cites W2775638527 @default.
• W2912794152 cites W2778977385 @default.
• W2912794152 cites W2796208857 @default.
• W2912794152 cites W2802023214 @default.
• W2912794152 cites W2803737891 @default.
• W2912794152 cites W2805989698 @default.
• W2912794152 cites W2886296499 @default.
• W2912794152 doi "https://doi.org/10.3389/fnins.2019.00007" @default.
• W2912794152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6351484" @default.
• W2912794152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30728762" @default.
• W2912794152 hasPublicationYear "2019" @default.
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