FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912796484> ?p ?o ?g. }

• W2912796484 endingPage "S793" @default.
• W2912796484 startingPage "S792" @default.
• W2912796484 abstract "Breast Cancer is the second most common malignancy in women in the United States. Although ILC accounts for only 10-14% of all breast cancer cases, gastrointestinal (GI) metastasis are more frequently associated with ILC as compared to invasive ductal carcinoma. Its characteristic appearance can mimic IBD and colorectal cancer on endoscopic and radiological evaluation. A 68-year old female with history of recurrent metastatic ILC, on Palbociclib based chemotherapy regimen presented to the ED with lower abdominal pain, constipation associated with nausea and vomiting for 3 days. Physical exam demonstrated a firm distended abdomen with lower quadrant tenderness. An X-ray of the abdomen showed multiple dilated loops of bowel with air-fluid levels. Non-contrast CT of the abdomen demonstrated a transition point within the distal sigmoid colon. Flouroscopy with gastrografin enema and Contrast MRI of the abdomen showed “apple core lesion” with mucosal irregularities in the proximal sigmoid along with proximal large bowel obstruction suggestive of colon cancer (Fig 1). Colonoscopy revealed a 3 cm long stenotic area in the sigmoid. Biopsies were obtained and a 22 mm x 9 cm Wall Flex stent was placed under fluoroscopic guidance (Fig 2). The Histopathologic features were consistent with metastatic ILC with Immunohistochemical (IHC) stains positive for CK7, Pan Keratin and GATA-3 (Fig 3). The metastatic tumor cells also showed strong nuclear expression of ER and PR, further supporting the diagnosis of metastatic breast cancer and ruling out colonic adenocarcinoma. Patient was subsequently started on Everolimus based chemotherapy for her progressive metastatic breast cancer. Colonic metastasis from breast carcinoma are rare. Metastatic ILC infiltrates the serosa, muscularis and the submucosal layers of the GI tract, sometimes presenting with circumferential narrowing and thickening mimicking primary GI pathologies like CRC and IBD. The role of IHC and biopsy is of paramount importance to distinguish this metastatic disease from primary colon pathologies like CRC or IBD.A high index of suspicion for possible GI metastasis should be maintained in patients with a history of ILC presenting with colonic mass or obstruction. Although associated with a poor prognosis establishing a definite diagnosis is pertinent to institute appropriate treatment.Figure: Fluoroscopy with gastrografin enema and MRI of the abdomen showing Apple core lesion.Figure: Colonoscopic images showing circumferential stenotic lesion and colonic stent in-situ.Figure: Biopsy of the sigmoid mass shows histological pattern consistent with ILC breast with immunohistological staining positive for Pankeratin, GATA -3 and CK-7." @default.
• W2912796484 created "2019-02-21" @default.
• W2912796484 creator A5020024902 @default.
• W2912796484 creator A5020466569 @default.
• W2912796484 creator A5061025554 @default.
• W2912796484 date "2017-10-01" @default.
• W2912796484 modified "2023-09-27" @default.
• W2912796484 title "Metastatic Invasive Lobular Carcinoma (ILC) of the Breast Presenting as Apple Core Lesion of the Colon Mimicking Colorectal Adenocarcinoma" @default.
• W2912796484 doi "https://doi.org/10.14309/00000434-201710001-01453" @default.
• W2912796484 hasPublicationYear "2017" @default.
• W2912796484 type Work @default.
• W2912796484 sameAs 2912796484 @default.
• W2912796484 citedByCount "0" @default.
• W2912796484 crossrefType "journal-article" @default.
• W2912796484 hasAuthorship W2912796484A5020024902 @default.
• W2912796484 hasAuthorship W2912796484A5020466569 @default.
• W2912796484 hasAuthorship W2912796484A5061025554 @default.
• W2912796484 hasConcept C121608353 @default.
• W2912796484 hasConcept C126322002 @default.
• W2912796484 hasConcept C126838900 @default.
• W2912796484 hasConcept C2775930923 @default.
• W2912796484 hasConcept C2776372563 @default.
• W2912796484 hasConcept C2776870353 @default.
• W2912796484 hasConcept C2778435480 @default.
• W2912796484 hasConcept C2779983558 @default.
• W2912796484 hasConcept C2781074409 @default.
• W2912796484 hasConcept C2781182431 @default.
• W2912796484 hasConcept C3020375857 @default.
• W2912796484 hasConcept C526805850 @default.
• W2912796484 hasConcept C530470458 @default.
• W2912796484 hasConcept C71924100 @default.
• W2912796484 hasConceptScore W2912796484C121608353 @default.
• W2912796484 hasConceptScore W2912796484C126322002 @default.
• W2912796484 hasConceptScore W2912796484C126838900 @default.
• W2912796484 hasConceptScore W2912796484C2775930923 @default.
• W2912796484 hasConceptScore W2912796484C2776372563 @default.
• W2912796484 hasConceptScore W2912796484C2776870353 @default.
• W2912796484 hasConceptScore W2912796484C2778435480 @default.
• W2912796484 hasConceptScore W2912796484C2779983558 @default.
• W2912796484 hasConceptScore W2912796484C2781074409 @default.
• W2912796484 hasConceptScore W2912796484C2781182431 @default.
• W2912796484 hasConceptScore W2912796484C3020375857 @default.
• W2912796484 hasConceptScore W2912796484C526805850 @default.
• W2912796484 hasConceptScore W2912796484C530470458 @default.
• W2912796484 hasConceptScore W2912796484C71924100 @default.
• W2912796484 hasLocation W29127964841 @default.
• W2912796484 hasOpenAccess W2912796484 @default.
• W2912796484 hasPrimaryLocation W29127964841 @default.
• W2912796484 hasRelatedWork W1499635367 @default.
• W2912796484 hasRelatedWork W2050336476 @default.
• W2912796484 hasRelatedWork W2150621467 @default.
• W2912796484 hasRelatedWork W2363593670 @default.
• W2912796484 hasRelatedWork W2387773904 @default.
• W2912796484 hasRelatedWork W2391175803 @default.
• W2912796484 hasRelatedWork W2416163708 @default.
• W2912796484 hasRelatedWork W2473764998 @default.
• W2912796484 hasRelatedWork W2907322099 @default.
• W2912796484 hasRelatedWork W4366596396 @default.
• W2912796484 hasVolume "112" @default.
• W2912796484 isParatext "false" @default.
• W2912796484 isRetracted "false" @default.
• W2912796484 magId "2912796484" @default.
• W2912796484 workType "article" @default.