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- W2912797542 abstract "The mechanism of latency and the ability of the cyprinid herpesvirus 3 (CyHV-3) to establish life-long infections in carp remains poorly understood. To explain the role of miRNAs in this process we applied a range of molecular tools including high-throughput sequencing of RNA libraries constructed from the blood samples of infected fish followed by bioinformatic and functional analyses which show that CyHV-3 profoundly influences the expression of host miRNAs in vivo. We demonstrated the changed expression of 27 miRNAs in the clinical phase and 5 in the latent phase of infection. We also identified 23 novel, not previously reported sequences, from which 8 showed altered expressions in control phase, 10 in clinical phase and 5 in latent phase of infection. The results of our analysis expand the knowledge of common carp microRNAs engaged during CyHV-3 infection and provide a useful basis for the further study of the mechanism of CyHV-3 induced pathology." @default.
- W2912797542 created "2019-02-21" @default.
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- W2912797542 date "2019-01-16" @default.
- W2912797542 modified "2023-10-17" @default.
- W2912797542 title "Host microRNA analysis in cyprinid Herpesvirus-3 (CyHV-3) infected common carp" @default.
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- W2912797542 doi "https://doi.org/10.1186/s12864-018-5266-9" @default.
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