FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912798676> ?p ?o ?g. }

• W2912798676 endingPage "526" @default.
• W2912798676 startingPage "516" @default.
• W2912798676 abstract "The extracellular matrix (ECM) influences the structure and function of the arterial wall and modulates the behavior of vascular cells through ECM-cell interactions. Alterations to the ECM have been implicated in multiple pathological processes, including atherosclerosis which is characterized by low-grade chronic inflammation and the infiltration and proliferation of smooth muscle cells during disease development. Considerable evidence has been presented for a role for inflammation-derived oxidation in atherogenesis, with enzymatically-active myeloperoxidase (MPO), elevated levels of 3-chlorotyrosine (a biomarker of MPO-catalyzed damage) and oxidized ECM materials detected in advanced human atherosclerotic lesions. Whether oxidant-modified ECM contributes to the altered behavior of smooth muscle cells is however unclear. This study therefore investigated the effects of hypochlorous acid (HOCl), a major MPO-derived oxidant, on the structure of the native ECM synthesized by human coronary artery smooth muscle cells (HCAMSCs) and whether modified ECM proteins affected HCASMC adhesion, proliferation and gene expression. Exposure of native HCASMC-derived ECM to reagent HOCl or a MPO-Cl--H2O2 system resulted in extensive ECM modifications as evidenced by the loss of antibody recognition of epitopes on type IV collagen, laminin, versican and fibronectin. Oxidation of HCASMC ECM markedly reduced HCASMC adhesion to matrix components, but facilitated subsequent proliferation in vitro. Multiple genes were upregulated in HCASMCs in response to HOCl-modified HCASMC-ECM including interleukin-6 (IL-6), fibronectin (FN1) and matrix-metalloproteinases (MMPs). These data reveal a mechanism through which inflammation-induced ECM-modification may contribute to the behavioral switching of HCASMCs, a key process in plaque formation during the development of atherosclerosis." @default.
• W2912798676 created "2019-02-21" @default.
• W2912798676 creator A5022952613 @default.
• W2912798676 creator A5069317976 @default.
• W2912798676 creator A5082145076 @default.
• W2912798676 creator A5085857115 @default.
• W2912798676 creator A5091680821 @default.
• W2912798676 date "2019-04-01" @default.
• W2912798676 modified "2023-09-24" @default.
• W2912798676 title "Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells" @default.
• W2912798676 cites W1503156937 @default.
• W2912798676 cites W1797648448 @default.
• W2912798676 cites W1849707633 @default.
• W2912798676 cites W1964457547 @default.
• W2912798676 cites W1971435128 @default.
• W2912798676 cites W1976428700 @default.
• W2912798676 cites W1976616659 @default.
• W2912798676 cites W1984738546 @default.
• W2912798676 cites W1987430295 @default.
• W2912798676 cites W1987749678 @default.
• W2912798676 cites W1988804288 @default.
• W2912798676 cites W1990059556 @default.
• W2912798676 cites W1993189466 @default.
• W2912798676 cites W1996424850 @default.
• W2912798676 cites W2002970663 @default.
• W2912798676 cites W2009292265 @default.
• W2912798676 cites W2012607933 @default.
• W2912798676 cites W2013204959 @default.
• W2912798676 cites W2018135697 @default.
• W2912798676 cites W2024653871 @default.
• W2912798676 cites W2028257547 @default.
• W2912798676 cites W2028495064 @default.
• W2912798676 cites W2040447429 @default.
• W2912798676 cites W2045166620 @default.
• W2912798676 cites W2047023602 @default.
• W2912798676 cites W2054893928 @default.
• W2912798676 cites W2058000049 @default.
• W2912798676 cites W2058610272 @default.
• W2912798676 cites W2060719968 @default.
• W2912798676 cites W2067504868 @default.
• W2912798676 cites W2067955790 @default.
• W2912798676 cites W2073061419 @default.
• W2912798676 cites W2075034126 @default.
• W2912798676 cites W2076846032 @default.
• W2912798676 cites W2077932966 @default.
• W2912798676 cites W2079724669 @default.
• W2912798676 cites W2081489071 @default.
• W2912798676 cites W2081527966 @default.
• W2912798676 cites W2088718636 @default.
• W2912798676 cites W2105048548 @default.
• W2912798676 cites W2106319388 @default.
• W2912798676 cites W2113934014 @default.
• W2912798676 cites W2114349116 @default.
• W2912798676 cites W2114490800 @default.
• W2912798676 cites W2118480498 @default.
• W2912798676 cites W2118848380 @default.
• W2912798676 cites W2145865564 @default.
• W2912798676 cites W2146895186 @default.
• W2912798676 cites W2150795824 @default.
• W2912798676 cites W2152221103 @default.
• W2912798676 cites W2159087408 @default.
• W2912798676 cites W2164637490 @default.
• W2912798676 cites W2168549718 @default.
• W2912798676 cites W2169177269 @default.
• W2912798676 cites W2274924551 @default.
• W2912798676 cites W2329935557 @default.
• W2912798676 cites W2467269011 @default.
• W2912798676 cites W2556664014 @default.
• W2912798676 cites W2599288929 @default.
• W2912798676 cites W2770669941 @default.
• W2912798676 cites W2889820585 @default.
• W2912798676 cites W2899232733 @default.
• W2912798676 doi "https://doi.org/10.1016/j.freeradbiomed.2019.01.044" @default.
• W2912798676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30716431" @default.
• W2912798676 hasPublicationYear "2019" @default.
• W2912798676 type Work @default.
• W2912798676 sameAs 2912798676 @default.
• W2912798676 citedByCount "24" @default.
• W2912798676 countsByYear W29127986762019 @default.
• W2912798676 countsByYear W29127986762020 @default.
• W2912798676 countsByYear W29127986762021 @default.
• W2912798676 countsByYear W29127986762022 @default.
• W2912798676 countsByYear W29127986762023 @default.
• W2912798676 crossrefType "journal-article" @default.
• W2912798676 hasAuthorship W2912798676A5022952613 @default.
• W2912798676 hasAuthorship W2912798676A5069317976 @default.
• W2912798676 hasAuthorship W2912798676A5082145076 @default.
• W2912798676 hasAuthorship W2912798676A5085857115 @default.
• W2912798676 hasAuthorship W2912798676A5091680821 @default.
• W2912798676 hasConcept C109523444 @default.
• W2912798676 hasConcept C1491633281 @default.
• W2912798676 hasConcept C159470946 @default.
• W2912798676 hasConcept C185592680 @default.
• W2912798676 hasConcept C189165786 @default.
• W2912798676 hasConcept C203014093 @default.
• W2912798676 hasConcept C203565725 @default.
• W2912798676 hasConcept C2776914184 @default.
• W2912798676 hasConcept C2779335624 @default.

• next