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• W2912798684 abstract "We thank Dr. Boboridis and colleagues for their interest in our paper. We realized our omission regarding the Cochrane review (which one of our authors co-authored) shortly after publication. We welcome the opportunity to highlight the fact that there may still be value in so-called “empty” reviews. However, a single trial will not permit a meta-analysis as suggested by Dr. Boboridis. The study did indeed terminate prior to its intended recruitment target which was lamentable, but reasons for this were clearly stated in the paper. The study evaluated the study end point at 18 months, and Dr. Boboridis is correct that this would exclude rare yet important adverse late events. The reported 4-year mortality rate of patients suffering from involutional entropion is 30%.1Wright M. Bell D. Scott C. Leatherbarrow B. Everting suture correction of lower lid involutional entropion.Br J Ophthalmol. 1999; 83: 1060-1063Crossref PubMed Scopus (47) Google Scholar A longer-term, prospective study is thus expected to have a high patient ‘dropout rate.’ Also, randomized, controlled trials (RCTs) are typically not the best source of evidence, for evidence of harm because RCTs are often not able to recruit as many patients as retrospective studies. In our study, we were only able to recruit 63 patients. Patients with excessive medial canthal tendon laxity were excluded from the study because we feel that these patients should not have a lateral tarsal strip procedure but rather medial canthal tendon surgery in order to avoid excessive lateral displacement of the medial canthus and punctum. The figures that Dr. Boboridis quotes are from a retrospective case review, which is prone to numerous sources of bias, and thus we would prefer to place greater stress on the results of this RCT. We agree that a single trial cannot provide all answers to all questions, and that further research in this area which affects many elderly patients is required. EntropionOphthalmologyVol. 118Issue 1PreviewIn their recent interesting article, Scheepers et al1 have compared the surgical outcome of everting sutures (ES) alone versus everting sutures with a lateral tarsal strip (ES+LTS) in the treatment of primary involutional lower lid entropion. We wish to emphasize the importance of this publication as the first prospective randomized clinical trial (RCT) in the field of entropion surgery with a very high level of evidence (Ib) for research and clinical practice. This will be the first RCT to be included in a Cochrane systematic review and meta-analysis of clinical trials for involutional entropion. Full-Text PDF" @default.
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• W2912798684 date "2011-01-01" @default.
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• W2912798684 doi "https://doi.org/10.1016/j.ophtha.2010.08.004" @default.
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