Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912798934> ?p ?o ?g. }
Showing items 1 to 45 of
45
with 100 items per page.
- W2912798934 endingPage "180" @default.
- W2912798934 startingPage "128" @default.
- W2912798934 abstract "The desire for brain penetrant kinase inhibitors has increased in recent years to enable the treatment of both primary and secondary brain tumours but also for the potential management of degenerative CNS diseases such as Alzheimer's and Parkinson's diseases. However, the design of compounds that are able to access the brain is a formidable challenge, exacerbated by the fact that traditional kinase inhibitor design space does not overlap well with the physicochemical properties of established CNS compounds. This chapter overviews the challenges facing kinase medicinal chemists and highlights progress to date, illustrating with a growing number of successful kinase inhibitor case histories where brain penetration has now been obtained and shown to drive in vivo CNS efficacy." @default.
- W2912798934 created "2019-02-21" @default.
- W2912798934 creator A5050785711 @default.
- W2912798934 creator A5081430961 @default.
- W2912798934 date "2018-01-01" @default.
- W2912798934 modified "2023-09-25" @default.
- W2912798934 title "CHAPTER 6. The Design of Brain Penetrant Kinase Inhibitors" @default.
- W2912798934 doi "https://doi.org/10.1039/9781788013093-00128" @default.
- W2912798934 hasPublicationYear "2018" @default.
- W2912798934 type Work @default.
- W2912798934 sameAs 2912798934 @default.
- W2912798934 citedByCount "1" @default.
- W2912798934 countsByYear W29127989342021 @default.
- W2912798934 crossrefType "book-chapter" @default.
- W2912798934 hasAuthorship W2912798934A5050785711 @default.
- W2912798934 hasAuthorship W2912798934A5081430961 @default.
- W2912798934 hasConcept C15744967 @default.
- W2912798934 hasConcept C169760540 @default.
- W2912798934 hasConcept C178790620 @default.
- W2912798934 hasConcept C185592680 @default.
- W2912798934 hasConcept C2779335537 @default.
- W2912798934 hasConceptScore W2912798934C15744967 @default.
- W2912798934 hasConceptScore W2912798934C169760540 @default.
- W2912798934 hasConceptScore W2912798934C178790620 @default.
- W2912798934 hasConceptScore W2912798934C185592680 @default.
- W2912798934 hasConceptScore W2912798934C2779335537 @default.
- W2912798934 hasLocation W29127989341 @default.
- W2912798934 hasOpenAccess W2912798934 @default.
- W2912798934 hasPrimaryLocation W29127989341 @default.
- W2912798934 hasRelatedWork W1531601525 @default.
- W2912798934 hasRelatedWork W1990781990 @default.
- W2912798934 hasRelatedWork W2314643286 @default.
- W2912798934 hasRelatedWork W2606768298 @default.
- W2912798934 hasRelatedWork W2606769243 @default.
- W2912798934 hasRelatedWork W2606837276 @default.
- W2912798934 hasRelatedWork W2748952813 @default.
- W2912798934 hasRelatedWork W2899084033 @default.
- W2912798934 hasRelatedWork W2948807893 @default.
- W2912798934 hasRelatedWork W2778153218 @default.
- W2912798934 isParatext "false" @default.
- W2912798934 isRetracted "false" @default.
- W2912798934 magId "2912798934" @default.
- W2912798934 workType "book-chapter" @default.