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- W2912800993 abstract "There is an urgent need for therapeutic agents that target humoral alloimmunity in solid organ transplantation. This includes sensitized patients with preformed donor-specific human leukocyte antigen antibodies and patients who develop de novo donor-specific antibodies, both of which are associated with acute and chronic antibody-mediated rejection and allograft loss. In the last decade, both experimental and clinical studies highlighted the major impact of costimulation molecules in the control of immune responses both in the field of transplantation and autoimmune disease. Although these molecules have been initially developed to control the early steps of T-cell activation, recent evidence also supports their influence at several steps of the humoral response. In this review, we aim to provide an overview of the current knowledge of the effects of costimulatory blockade agents on humoral responses in both autoimmune and allogeneic contexts. We first present the effects of costimulatory molecules on the different steps of alloantibody production. We then summarize mechanisms and clinical results observed using cytotoxic T lymphocyte antigen-4 (CTLA4)-Ig molecules both in transplantation and autoimmunity. Finally, we present the potential interest and implications of other costimulatory family members as therapeutic targets, with emphasis on combinatorial approaches, for the optimal control of the alloantigen-specific humoral response. There is an urgent need for therapeutic agents that target humoral alloimmunity in solid organ transplantation. This includes sensitized patients with preformed donor-specific human leukocyte antigen antibodies and patients who develop de novo donor-specific antibodies, both of which are associated with acute and chronic antibody-mediated rejection and allograft loss. In the last decade, both experimental and clinical studies highlighted the major impact of costimulation molecules in the control of immune responses both in the field of transplantation and autoimmune disease. Although these molecules have been initially developed to control the early steps of T-cell activation, recent evidence also supports their influence at several steps of the humoral response. In this review, we aim to provide an overview of the current knowledge of the effects of costimulatory blockade agents on humoral responses in both autoimmune and allogeneic contexts. We first present the effects of costimulatory molecules on the different steps of alloantibody production. We then summarize mechanisms and clinical results observed using cytotoxic T lymphocyte antigen-4 (CTLA4)-Ig molecules both in transplantation and autoimmunity. Finally, we present the potential interest and implications of other costimulatory family members as therapeutic targets, with emphasis on combinatorial approaches, for the optimal control of the alloantigen-specific humoral response." @default.
- W2912800993 created "2019-02-21" @default.
- W2912800993 creator A5000254733 @default.
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- W2912800993 creator A5054118199 @default.
- W2912800993 creator A5088819374 @default.
- W2912800993 date "2019-04-01" @default.
- W2912800993 modified "2023-10-03" @default.
- W2912800993 title "Costimulatory blockade molecules and B-cell–mediated immune response: current knowledge and perspectives" @default.
- W2912800993 cites W1485526722 @default.
- W2912800993 cites W1486598251 @default.
- W2912800993 cites W1493299959 @default.
- W2912800993 cites W1496397714 @default.
- W2912800993 cites W1506151781 @default.
- W2912800993 cites W1506252195 @default.
- W2912800993 cites W1508120038 @default.
- W2912800993 cites W1521092162 @default.
- W2912800993 cites W1526559676 @default.
- W2912800993 cites W1528492996 @default.
- W2912800993 cites W1535248058 @default.
- W2912800993 cites W1554670304 @default.
- W2912800993 cites W1556459637 @default.
- W2912800993 cites W1566236740 @default.
- W2912800993 cites W1581554632 @default.
- W2912800993 cites W1585519602 @default.
- W2912800993 cites W1586397055 @default.
- W2912800993 cites W1678305509 @default.
- W2912800993 cites W1702319215 @default.
- W2912800993 cites W1759641455 @default.
- W2912800993 cites W1901606394 @default.
- W2912800993 cites W1917713593 @default.
- W2912800993 cites W1930372002 @default.
- W2912800993 cites W1937508021 @default.
- W2912800993 cites W1959883458 @default.
- W2912800993 cites W1966384388 @default.
- W2912800993 cites W1968155663 @default.
- W2912800993 cites W1971308765 @default.
- W2912800993 cites W1971522146 @default.
- W2912800993 cites W1972518526 @default.
- W2912800993 cites W1977237743 @default.
- W2912800993 cites W1978302597 @default.
- W2912800993 cites W1981732254 @default.
- W2912800993 cites W1982007449 @default.
- W2912800993 cites W1983795855 @default.
- W2912800993 cites W1985173426 @default.
- W2912800993 cites W1986141384 @default.
- W2912800993 cites W1987189578 @default.
- W2912800993 cites W1994649501 @default.
- W2912800993 cites W1998217670 @default.
- W2912800993 cites W1999260605 @default.
- W2912800993 cites W2000049562 @default.
- W2912800993 cites W2000664994 @default.
- W2912800993 cites W2001775594 @default.
- W2912800993 cites W2003842888 @default.
- W2912800993 cites W2008304542 @default.
- W2912800993 cites W2014541497 @default.
- W2912800993 cites W2016844693 @default.
- W2912800993 cites W2017219476 @default.
- W2912800993 cites W2017390384 @default.
- W2912800993 cites W2019447967 @default.
- W2912800993 cites W2019638031 @default.
- W2912800993 cites W2020425148 @default.
- W2912800993 cites W2021672128 @default.
- W2912800993 cites W2023780869 @default.
- W2912800993 cites W2028028348 @default.
- W2912800993 cites W2029161762 @default.
- W2912800993 cites W2031817808 @default.
- W2912800993 cites W2032060551 @default.
- W2912800993 cites W2042043269 @default.
- W2912800993 cites W2044300780 @default.
- W2912800993 cites W2046146126 @default.
- W2912800993 cites W2052946980 @default.
- W2912800993 cites W2055923182 @default.
- W2912800993 cites W2056440702 @default.
- W2912800993 cites W2057648030 @default.
- W2912800993 cites W2059427290 @default.
- W2912800993 cites W2060187954 @default.
- W2912800993 cites W2061234870 @default.
- W2912800993 cites W2065695595 @default.
- W2912800993 cites W2066489069 @default.
- W2912800993 cites W2066671159 @default.
- W2912800993 cites W2071380288 @default.
- W2912800993 cites W2075805721 @default.
- W2912800993 cites W2076820280 @default.
- W2912800993 cites W2078413135 @default.
- W2912800993 cites W2081613377 @default.
- W2912800993 cites W2087169300 @default.
- W2912800993 cites W2090638899 @default.
- W2912800993 cites W2092382141 @default.
- W2912800993 cites W2092706820 @default.
- W2912800993 cites W2094538904 @default.
- W2912800993 cites W2095109339 @default.
- W2912800993 cites W2097147259 @default.
- W2912800993 cites W2097228520 @default.
- W2912800993 cites W2098881967 @default.
- W2912800993 cites W2102207725 @default.