FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912803953> ?p ?o ?g. }

• W2912803953 endingPage "123" @default.
• W2912803953 startingPage "112" @default.
• W2912803953 abstract "Microbial diseases remain to be a major global public health challenge. Their devastating effects have been exacerbated by the development of drug resistant strains. On the other hand, the biodiversity of tropical Basidiomycetes fungi is well recognized as an untapped source of potential bioactive compounds for the development of novel antimicrobials. Thus, in the current study, Basidiomycetes’ fruiting bodies were collected from Mt. Elgon National Park forest in Kenya. The spores were cultured on Yeast Malt Agar media (YMG), leading to the establishment of 12 distinct pure fungal cultures of Basidiomycete strains, which were characterized using ribosomal internal transcribed spacer (ITS) DNA. They generally belonged to genera; Inonotus, Fomitiporia, Ganoderma, Skeletocutis, Perenniporia, Favolaschia, Hexagonia, Polyporus, Antrodia and Echinochaete. Fungal mycelia were further fermented in YMG, Q6½ (cotton-seed) and ZM½ (sugar-malt) liquid media for secondary metabolites’ production. These were extracted using ethyl-acetate and subjected to antimicrobial assays against Bacillus subtilis, Escherichia coli, Mucor plumbeus and Candida albicans. Antimicrobial activity was exhibited in 9 out of the 12 strains cultured, where antibacterial activity was more pronounced than fungal antagonism. Mycelial crude extracts from strains identified as Skeletocutis nivea and Favolaschia calocera demonstrated the highest activities against bacteria (B. subtilis) and fungal pathogen (C. tenuis), respectively with minimum inhibitory concentration (MIC) values of 4.69 µg/ml and <2.34 µg/ml, as compared to ciprofloxacin and nystatin controls which exhibited MIC values of <2.34 µg/ml each. In addition, crude extracts from Hexagonia sp and Inonotus pachyphloeus inhibited growth of E. coli at 300 µg/ml each, while M. plumbeus growth was inhibited by extracts from F. calocera and S. nivea at 37.5 and 300 µg/ml, respectively. These results clearly demonstrate that Basidiomycetes are a reservoir to antimicrobial fungal metabolites, which can be exploited as lead compounds to address drug resistance menace.   Key words:  Drug resistance, basidiomycetes, antimicrobial, fungal metabolites." @default.
• W2912803953 created "2019-02-21" @default.
• W2912803953 creator A5026353937 @default.
• W2912803953 creator A5061788478 @default.
• W2912803953 creator A5085832485 @default.
• W2912803953 date "2019-01-30" @default.
• W2912803953 modified "2023-09-27" @default.
• W2912803953 title "Antimicrobial activity of Basidiomycetes fungi isolated from a Kenyan tropical forest" @default.
• W2912803953 cites W1542259662 @default.
• W2912803953 cites W1969668106 @default.
• W2912803953 cites W1980876687 @default.
• W2912803953 cites W1985207595 @default.
• W2912803953 cites W1992900147 @default.
• W2912803953 cites W1995674722 @default.
• W2912803953 cites W2006747169 @default.
• W2912803953 cites W2012251902 @default.
• W2912803953 cites W2019693917 @default.
• W2912803953 cites W2049082243 @default.
• W2912803953 cites W2064906725 @default.
• W2912803953 cites W2067838702 @default.
• W2912803953 cites W2081805658 @default.
• W2912803953 cites W2084162854 @default.
• W2912803953 cites W2095667786 @default.
• W2912803953 cites W2097769208 @default.
• W2912803953 cites W2099892012 @default.
• W2912803953 cites W2110375946 @default.
• W2912803953 cites W2117916227 @default.
• W2912803953 cites W2120772351 @default.
• W2912803953 cites W2122427889 @default.
• W2912803953 cites W2123479846 @default.
• W2912803953 cites W2126409614 @default.
• W2912803953 cites W2128880918 @default.
• W2912803953 cites W2130889389 @default.
• W2912803953 cites W2136280209 @default.
• W2912803953 cites W2137015675 @default.
• W2912803953 cites W2336330109 @default.
• W2912803953 cites W2531875746 @default.
• W2912803953 cites W4232117644 @default.
• W2912803953 cites W4249571484 @default.
• W2912803953 cites W4253133660 @default.
• W2912803953 doi "https://doi.org/10.5897/ajb2018.16660" @default.
• W2912803953 hasPublicationYear "2019" @default.
• W2912803953 type Work @default.
• W2912803953 sameAs 2912803953 @default.
• W2912803953 citedByCount "1" @default.
• W2912803953 countsByYear W29128039532022 @default.
• W2912803953 crossrefType "journal-article" @default.
• W2912803953 hasAuthorship W2912803953A5026353937 @default.
• W2912803953 hasAuthorship W2912803953A5061788478 @default.
• W2912803953 hasAuthorship W2912803953A5085832485 @default.
• W2912803953 hasBestOaLocation W29128039531 @default.
• W2912803953 hasConcept C133479454 @default.
• W2912803953 hasConcept C2779345646 @default.
• W2912803953 hasConcept C4937899 @default.
• W2912803953 hasConcept C59822182 @default.
• W2912803953 hasConcept C86803240 @default.
• W2912803953 hasConcept C89423630 @default.
• W2912803953 hasConceptScore W2912803953C133479454 @default.
• W2912803953 hasConceptScore W2912803953C2779345646 @default.
• W2912803953 hasConceptScore W2912803953C4937899 @default.
• W2912803953 hasConceptScore W2912803953C59822182 @default.
• W2912803953 hasConceptScore W2912803953C86803240 @default.
• W2912803953 hasConceptScore W2912803953C89423630 @default.
• W2912803953 hasIssue "5" @default.
• W2912803953 hasLocation W29128039531 @default.
• W2912803953 hasOpenAccess W2912803953 @default.
• W2912803953 hasPrimaryLocation W29128039531 @default.
• W2912803953 hasRelatedWork W2018583461 @default.
• W2912803953 hasRelatedWork W2091219986 @default.
• W2912803953 hasRelatedWork W2093230740 @default.
• W2912803953 hasRelatedWork W2362093258 @default.
• W2912803953 hasRelatedWork W2363686339 @default.
• W2912803953 hasRelatedWork W2373007251 @default.
• W2912803953 hasRelatedWork W2387075545 @default.
• W2912803953 hasRelatedWork W2482623811 @default.
• W2912803953 hasRelatedWork W2915028625 @default.
• W2912803953 hasRelatedWork W4254314521 @default.
• W2912803953 hasVolume "18" @default.
• W2912803953 isParatext "false" @default.
• W2912803953 isRetracted "false" @default.
• W2912803953 magId "2912803953" @default.
• W2912803953 workType "article" @default.