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- W2912804279 abstract "Histological analysis of donor pancreases coupled with measurement of serum C-peptide in clinical cohorts has challenged the idea that all beta cells are eventually destroyed in type 1 diabetes. These findings have raised a number of questions regarding how the remaining beta cells have escaped immune destruction, whether pools of 'sleeping' or dysfunctional beta cells could be rejuvenated and whether there is potential for new growth of beta cells. In this Review, we describe histological and in vivo evidence of persistent beta cells in type 1 diabetes and discuss the limitations of current methods to distinguish underlying beta cell mass in comparison with beta cell function. We highlight that evidence for new beta cell growth in humans many years from diagnosis is limited, and that this growth may be very minimal if at all present. We review recent contributions to the debate around beta cell abnormalities contributing to the pathogenesis of type 1 diabetes. We also discuss evidence for restoration of beta cell function, as opposed to mass, in recent-onset type 1 diabetes, but highlight the absence of data supporting functional recovery in the setting of long-duration diabetes. Finally, future areas of research are suggested to help resolve the source and phenotype of residual beta cells that persist in some, but not all, people with type 1 diabetes." @default.
- W2912804279 created "2019-02-21" @default.
- W2912804279 creator A5015558687 @default.
- W2912804279 creator A5035704912 @default.
- W2912804279 creator A5063131669 @default.
- W2912804279 date "2019-02-14" @default.
- W2912804279 modified "2023-10-14" @default.
- W2912804279 title "Beta cells in type 1 diabetes: mass and function; sleeping or dead?" @default.
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- W2912804279 doi "https://doi.org/10.1007/s00125-019-4822-4" @default.
- W2912804279 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6688846" @default.
- W2912804279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30767048" @default.
- W2912804279 hasPublicationYear "2019" @default.
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