FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912807058> ?p ?o ?g. }

• W2912807058 abstract "Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blockade. This suggests a possible role for CNS inflammation in arthritis that may be affected by TNF blockade. We therefore investigated the effects of TNF blockade on the arthritis CSF proteome and how candidate proteins related to clinical measures of disease activity and inflammation.Mass spectrometry-based quantitative proteomic analysis was performed on CSF from seven polyarthritis patients before and during infliximab treatment. Treatment-associated proteins were identified using univariate (Wilcoxon signed rank test) and multivariate (partial least squares discriminant analysis (PLS-DA)) strategies. Relations between selected candidate proteins and clinical measures were investigated using the Spearman correlations. Additionally, selected proteins were cross-referenced to other studies investigating human CSF in a thorough literature search to ensure feasibility of our results.Univariate analysis of arthritis CSF proteome revealed a decrease of 35 proteins, predominantly involved in inflammatory processes, following TNF blockade. Seven candidate proteins, Contactin-1 (CNTN1), fibrinogen gamma chain (FGG), hemopexin (HPX), cell adhesion molecule-3 (CADM3), alpha-1B-glycoprotein (A1BG), complement factor B (CFB), and beta-2-microglobulin (B2M), were selected for further studies based on identification by both univariate and multivariate analyses and reported detection in human CSF and known associations to arthritis. Decreased levels of FGG and CFB in CSF after treatment showed strong correlations with both erythrocyte sedimentation rate and disability scores, while CNTN1 and CADM3 were associated with pain.Several immune-related proteins in the CSF of arthritis patients decreased during TNF blockade, including FGG and CFB that both correlated strongly with systemic inflammation. Our findings stress that also intrathecal inflammatory pathways are related to arthritis symptoms and may be affected by TNF blockade." @default.
• W2912807058 created "2019-02-21" @default.
• W2912807058 creator A5014599379 @default.
• W2912807058 creator A5016015447 @default.
• W2912807058 creator A5025148001 @default.
• W2912807058 creator A5038376395 @default.
• W2912807058 creator A5052621225 @default.
• W2912807058 creator A5053954343 @default.
• W2912807058 creator A5054438024 @default.
• W2912807058 creator A5074007983 @default.
• W2912807058 creator A5086796270 @default.
• W2912807058 creator A5089350013 @default.
• W2912807058 creator A5060809533 @default.
• W2912807058 date "2019-02-15" @default.
• W2912807058 modified "2023-10-08" @default.
• W2912807058 title "Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients—immune-related candidate proteins affected by TNF blocking treatment" @default.
• W2912807058 cites W1601943947 @default.
• W2912807058 cites W1754220940 @default.
• W2912807058 cites W1807844052 @default.
• W2912807058 cites W1842534109 @default.
• W2912807058 cites W1964919276 @default.
• W2912807058 cites W1969102065 @default.
• W2912807058 cites W1980275893 @default.
• W2912807058 cites W1985763670 @default.
• W2912807058 cites W1986309799 @default.
• W2912807058 cites W1987505659 @default.
• W2912807058 cites W2001577653 @default.
• W2912807058 cites W2003622777 @default.
• W2912807058 cites W2021205033 @default.
• W2912807058 cites W2022483135 @default.
• W2912807058 cites W2023286487 @default.
• W2912807058 cites W2026258433 @default.
• W2912807058 cites W2026309183 @default.
• W2912807058 cites W2027937356 @default.
• W2912807058 cites W2029884260 @default.
• W2912807058 cites W2034677311 @default.
• W2912807058 cites W2035500508 @default.
• W2912807058 cites W2035873332 @default.
• W2912807058 cites W2038475563 @default.
• W2912807058 cites W2039416520 @default.
• W2912807058 cites W2057378819 @default.
• W2912807058 cites W2063164889 @default.
• W2912807058 cites W2064661524 @default.
• W2912807058 cites W2065028487 @default.
• W2912807058 cites W2073134404 @default.
• W2912807058 cites W2077301497 @default.
• W2912807058 cites W2087402257 @default.
• W2912807058 cites W2092108048 @default.
• W2912807058 cites W2094124191 @default.
• W2912807058 cites W2101951838 @default.
• W2912807058 cites W2102501902 @default.
• W2912807058 cites W2104276961 @default.
• W2912807058 cites W2106447917 @default.
• W2912807058 cites W2108020835 @default.
• W2912807058 cites W2110177517 @default.
• W2912807058 cites W2110255764 @default.
• W2912807058 cites W2117340207 @default.
• W2912807058 cites W2131665068 @default.
• W2912807058 cites W2135659886 @default.
• W2912807058 cites W2135735522 @default.
• W2912807058 cites W2142424019 @default.
• W2912807058 cites W2143255467 @default.
• W2912807058 cites W2150702063 @default.
• W2912807058 cites W2153573134 @default.
• W2912807058 cites W2155382840 @default.
• W2912807058 cites W2161137669 @default.
• W2912807058 cites W2168221521 @default.
• W2912807058 cites W2169831748 @default.
• W2912807058 cites W2174721344 @default.
• W2912807058 cites W2219617771 @default.
• W2912807058 cites W2296257830 @default.
• W2912807058 cites W2339967094 @default.
• W2912807058 cites W2396501490 @default.
• W2912807058 cites W2416361228 @default.
• W2912807058 cites W2429710742 @default.
• W2912807058 cites W2463602203 @default.
• W2912807058 cites W2515452340 @default.
• W2912807058 cites W2596033074 @default.
• W2912807058 cites W2701062802 @default.
• W2912807058 cites W2729351500 @default.
• W2912807058 cites W4236254399 @default.
• W2912807058 cites W4313347683 @default.
• W2912807058 cites W2147726293 @default.
• W2912807058 doi "https://doi.org/10.1186/s13075-019-1846-6" @default.
• W2912807058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6377734" @default.
• W2912807058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30770760" @default.
• W2912807058 hasPublicationYear "2019" @default.
• W2912807058 type Work @default.
• W2912807058 sameAs 2912807058 @default.
• W2912807058 citedByCount "9" @default.
• W2912807058 countsByYear W29128070582019 @default.
• W2912807058 countsByYear W29128070582020 @default.
• W2912807058 countsByYear W29128070582022 @default.
• W2912807058 crossrefType "journal-article" @default.
• W2912807058 hasAuthorship W2912807058A5014599379 @default.
• W2912807058 hasAuthorship W2912807058A5016015447 @default.
• W2912807058 hasAuthorship W2912807058A5025148001 @default.
• W2912807058 hasAuthorship W2912807058A5038376395 @default.
• W2912807058 hasAuthorship W2912807058A5052621225 @default.
• W2912807058 hasAuthorship W2912807058A5053954343 @default.

• next