Matches in SemOpenAlex for { <https://semopenalex.org/work/W291280769> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- W291280769 abstract "Abstract : The goal of this initiative was to demonstrate the feasibility of deploying enzymatic tools within the vascular space for the purposes of detecting and disarming chemical and biological agents. The research succeeded in utilizing the red blood cell membrane surface as a platform on which to deploy an enzymatic defense system. The initial emphasis was changed from detection to protection because the molecular tools suitable for protection were immediately available. The project demonstrated that the intravascular platform provided by the red cell membrane and the strategy of enzymatic dismantling of a chemical threat agent were successful to a striking degree. The success included protection against a > 20 fold lethal dose of paraoxone that was rendered totally innocuous with this strategy in less than 1 minute. Moreover, covalent attachment to the red cell surface provided such levels of protection for more than 3 days, in contrast to the rapid disappearance (within 3 hours) of protectant molecular tools that were not so immobilized. The detection aspect of the proposed project was placed second in priority to the protection aspect, but was in principle demonstrated by the protection experiments. We still needed the additional step of generating a signal for the cleaved chemical agent which could be amplified by the principles utilized for enzyme coupled immunoassays to generate detectable gustatory or olfactory signals in urine or plasma. The strategy proved totally unobtrusive and strikingly effective in dismantling threat agents. More time was required for further development of the detection strategies." @default.
- W291280769 created "2016-06-24" @default.
- W291280769 creator A5014120421 @default.
- W291280769 creator A5030924082 @default.
- W291280769 date "2004-09-20" @default.
- W291280769 modified "2023-10-17" @default.
- W291280769 title "Use of an Erythrocyte Platform to Deploy Technology for Infection Detection" @default.
- W291280769 doi "https://doi.org/10.21236/ada426850" @default.
- W291280769 hasPublicationYear "2004" @default.
- W291280769 type Work @default.
- W291280769 sameAs 291280769 @default.
- W291280769 citedByCount "0" @default.
- W291280769 crossrefType "report" @default.
- W291280769 hasAuthorship W291280769A5014120421 @default.
- W291280769 hasAuthorship W291280769A5030924082 @default.
- W291280769 hasConcept C171250308 @default.
- W291280769 hasConcept C181199279 @default.
- W291280769 hasConcept C185592680 @default.
- W291280769 hasConcept C192562407 @default.
- W291280769 hasConcept C41008148 @default.
- W291280769 hasConcept C55493867 @default.
- W291280769 hasConceptScore W291280769C171250308 @default.
- W291280769 hasConceptScore W291280769C181199279 @default.
- W291280769 hasConceptScore W291280769C185592680 @default.
- W291280769 hasConceptScore W291280769C192562407 @default.
- W291280769 hasConceptScore W291280769C41008148 @default.
- W291280769 hasConceptScore W291280769C55493867 @default.
- W291280769 hasLocation W2912807691 @default.
- W291280769 hasOpenAccess W291280769 @default.
- W291280769 hasPrimaryLocation W2912807691 @default.
- W291280769 hasRelatedWork W1596801655 @default.
- W291280769 hasRelatedWork W1972437902 @default.
- W291280769 hasRelatedWork W2358668433 @default.
- W291280769 hasRelatedWork W2373011076 @default.
- W291280769 hasRelatedWork W2376932109 @default.
- W291280769 hasRelatedWork W2387147530 @default.
- W291280769 hasRelatedWork W2390279801 @default.
- W291280769 hasRelatedWork W2688602461 @default.
- W291280769 hasRelatedWork W2748952813 @default.
- W291280769 hasRelatedWork W2899084033 @default.
- W291280769 isParatext "false" @default.
- W291280769 isRetracted "false" @default.
- W291280769 magId "291280769" @default.
- W291280769 workType "report" @default.