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• W2912808485 abstract "The Front Cover shows three 11C-labeled positron emission tomography (PET) ligands based on a validated M4R positive allosteric modulator VU0467485 (AZ13713945). Five distinct subunits (M1–M5) of muscarinic acetylcholine receptors (mAChRs) are involved in the action of the neurotransmitter acetylcholine in the central and peripheral nervous system. Attributed to promising clinical efficacy of an M1/M4-preferring agonist Xanomeline in schizophrenic and Alzheimer's patients, M1 or M4-selective mAChR modulators have been developed that target the topographically distinct allosteric sites. Therefore, we developed prototype PET ligands to visualize the M4 target in the brain and provide preliminary evaluation of these novel chemical scaffolds for further medicinal chemistry development. More information can be found in the Communication by Shaofa Sun, Ming-Rong Zhang, Steven Liang et al. on page 303 in Issue 3, 2019 (DOI: 10.1002/cmdc.201800710)." @default.
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• W2912808485 date "2019-02-05" @default.
• W2912808485 modified "2023-09-26" @default.
• W2912808485 title "Front Cover: Synthesis and Preliminary Evaluation of 11 C‐Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4 (ChemMedChem 3/2019)" @default.
• W2912808485 doi "https://doi.org/10.1002/cmdc.201900047" @default.
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