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- W2912811032 endingPage "68" @default.
- W2912811032 startingPage "58" @default.
- W2912811032 abstract "Early life Stress is a worldwide concern linked with development of later life neurological disorders. Early developmental age is sensitive to many prominent environmental insults like malnourishment, immune inflammation, abuse, maternal separation, alcohol and drugs. Hence, an individual during an early age encounters more than one simultaneous stressor that leads to impairment of cognitive and behavioral abilities, a symptom common to most of the neurological disorders. Stressors like malnourishment and immune inflammation are common and encountered by a huge number of populations, contributing enormously to a damaged CNS and in most of the cases they act synergistically in dependency to each other, giving rise to the concept of multi-hit. Multi perinatal hit acts by mimicking the mechanism of ageing in CNS and increasing the risk for later life neurological disorders. Multi stress exposure is also responsible for disrupting the cellular homeostasis of the brain by inducing glial activation, neurotoxicity and oxidative stress, which is the major reason of cell death and circuitry damage in brain. Multi perinatal hit thus increases the risk of neurological disorders by many folds through interfering with ongoing developmental cascades and eventually modulating the fate of cellular components in brain. Thus, a stress induced architecturally and chemically altered CNS is vulnerable and prone to neurological disorders like Alzheimer's, Schizophrenia, ALS, Autism and Parkinson's disease. This review compiles the information available regarding the effects of early life stressors on different components of brain, primarily focusing on the connection between perinatally encountered multi hit and development of later life neurological disorders." @default.
- W2912811032 created "2019-02-21" @default.
- W2912811032 creator A5005717581 @default.
- W2912811032 creator A5022233494 @default.
- W2912811032 creator A5059465176 @default.
- W2912811032 date "2019-04-01" @default.
- W2912811032 modified "2023-10-01" @default.
- W2912811032 title "Cumulative multiple early life hits- a potent threat leading to neurological disorders" @default.
- W2912811032 cites W1627232924 @default.
- W2912811032 cites W1716645846 @default.
- W2912811032 cites W1821797507 @default.
- W2912811032 cites W1952322632 @default.
- W2912811032 cites W1965033387 @default.
- W2912811032 cites W1966020199 @default.
- W2912811032 cites W1968322025 @default.
- W2912811032 cites W1968996283 @default.
- W2912811032 cites W1971449558 @default.
- W2912811032 cites W1972009654 @default.
- W2912811032 cites W1974106429 @default.
- W2912811032 cites W1976273127 @default.
- W2912811032 cites W1977308172 @default.
- W2912811032 cites W1981917475 @default.
- W2912811032 cites W1983535683 @default.
- W2912811032 cites W1987183038 @default.
- W2912811032 cites W1987741893 @default.
- W2912811032 cites W1995100225 @default.
- W2912811032 cites W1995746794 @default.
- W2912811032 cites W1995994555 @default.
- W2912811032 cites W1996620282 @default.
- W2912811032 cites W1998105826 @default.
- W2912811032 cites W1998980503 @default.
- W2912811032 cites W2001179353 @default.
- W2912811032 cites W2001382581 @default.
- W2912811032 cites W2003136337 @default.
- W2912811032 cites W2003845849 @default.
- W2912811032 cites W2004052823 @default.
- W2912811032 cites W2005305743 @default.
- W2912811032 cites W2008378372 @default.
- W2912811032 cites W2013129680 @default.
- W2912811032 cites W2014366175 @default.
- W2912811032 cites W2015640363 @default.
- W2912811032 cites W2018332374 @default.
- W2912811032 cites W2018838561 @default.
- W2912811032 cites W2020651859 @default.
- W2912811032 cites W2021723653 @default.
- W2912811032 cites W2026406888 @default.
- W2912811032 cites W2027917639 @default.
- W2912811032 cites W2028581054 @default.
- W2912811032 cites W2028963033 @default.
- W2912811032 cites W2030985732 @default.
- W2912811032 cites W2032390975 @default.
- W2912811032 cites W2032784124 @default.
- W2912811032 cites W2034008819 @default.
- W2912811032 cites W2039981649 @default.
- W2912811032 cites W2040160279 @default.
- W2912811032 cites W2040678584 @default.
- W2912811032 cites W2041238959 @default.
- W2912811032 cites W2045926445 @default.
- W2912811032 cites W2046839899 @default.
- W2912811032 cites W2050320551 @default.
- W2912811032 cites W2051892149 @default.
- W2912811032 cites W2054878680 @default.
- W2912811032 cites W2055802011 @default.
- W2912811032 cites W2058157737 @default.
- W2912811032 cites W2062672657 @default.
- W2912811032 cites W2064278664 @default.
- W2912811032 cites W2064970594 @default.
- W2912811032 cites W2065699023 @default.
- W2912811032 cites W2069717852 @default.
- W2912811032 cites W2071180109 @default.
- W2912811032 cites W2073764523 @default.
- W2912811032 cites W2076583074 @default.
- W2912811032 cites W2076694429 @default.
- W2912811032 cites W2081326601 @default.
- W2912811032 cites W2082482546 @default.
- W2912811032 cites W2082977189 @default.
- W2912811032 cites W2085011950 @default.
- W2912811032 cites W2087191308 @default.
- W2912811032 cites W2090519295 @default.
- W2912811032 cites W2091447278 @default.
- W2912811032 cites W2093318093 @default.
- W2912811032 cites W2093575302 @default.
- W2912811032 cites W2093680881 @default.
- W2912811032 cites W2096065423 @default.
- W2912811032 cites W2099157718 @default.
- W2912811032 cites W2100463268 @default.
- W2912811032 cites W2101638698 @default.
- W2912811032 cites W2109342780 @default.
- W2912811032 cites W2109445380 @default.
- W2912811032 cites W2110184140 @default.
- W2912811032 cites W2110669207 @default.
- W2912811032 cites W2111063637 @default.
- W2912811032 cites W2112851246 @default.
- W2912811032 cites W2114038822 @default.
- W2912811032 cites W2115599658 @default.
- W2912811032 cites W2116510315 @default.
- W2912811032 cites W2116629441 @default.
- W2912811032 cites W2117066639 @default.