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- W2912820858 abstract "Auditory midbrain implant (AMI) targets the inferior colliculus (IC) in patients with no implantable cochlea such as the patients with neurofibromatosis type 2 (NF2). The present study investigated a new version of the AMI which enables 3-dimensional (3D) stimulation across the IC. Using cats as an animal model, 3 human AMIs were implanted side by side in the IC. The inferior colliculus central nucleus (ICC) was electrically stimulated with different stimulation levels and the evoked local field potentials (LFP) were recorded from the primary auditory cortex (A1). The objectives of the current study were to determine the basic response properties based on the LFP to this stimulation (threshold, latency, dynamic range (DR)) and to compare this to the previous studies. Further, we wanted to investigate whether the IC stimulation provokes different cortical responses by varying the recording site. The present study demonstrates that the human AMI electrodes can selectively activate different neuronal populations in the ICs of the cat. Furthermore, the study indicates that the stimulation results in activation of partially overlapping neuronal populations, leading to responses at both ON-BF and OFF-BF recording positions in the cortex. In total, these data demonstrate some stimulation site specificity, but also a large overlap of the excitation pattern induced by midbrain stimulation." @default.
- W2912820858 created "2019-02-21" @default.
- W2912820858 creator A5021151426 @default.
- W2912820858 date "2014-01-01" @default.
- W2912820858 modified "2023-09-23" @default.
- W2912820858 title "Functional enhancement of auditory activation through multi-site stimulation across the isofrequency dimension of the inferior colliculus" @default.
- W2912820858 hasPublicationYear "2014" @default.
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