FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912832580> ?p ?o ?g. }

• W2912832580 endingPage "12368" @default.
• W2912832580 startingPage "12353" @default.
• W2912832580 abstract "The mammalian target of rapamycin (mTOR) is a member of the evolutionary phosphatidylinositol kinase-related kinases (PIKKs). mTOR plays a pivotal role in the regulation of diverse aspects of cellular physiology such as body metabolism, cell growth, protein synthesis, cell size, autophagy, and cell differentiation. Immunologically, mTOR has a fundamental part in controlling and shaping diverse functions of innate and adaptive immune cells, in particular, T-cell subsets differentiation, survival, and metabolic reprogramming to ultimately regulate the fate of diverse immune cell types. Researchers report that rapamycin, a selective mTOR inhibitor, and immunosuppressive agent, has surprising immunostimulatory effects on inducing both quantitative and qualitative aspects of virus-specific memory CD8+ T-cells differentiation and homeostasis in a T-cell-intrinsic manner. The mTOR signaling pathway also plays a critical role in dictating the outcome of regulatory T cells (Treg), T helper 17 (Th17) cells, and natural killer (NK) cells proliferation and maturation, as well as the effector functions and cytotoxic properties of NK cells. Manipulation of mTOR activity is a critical therapeutic approach for pharmacological agents that seek to inhibit mTOR. This approach should enhance specific memory CD8 + T-cells responses and induce fully functional effector properties of NK cells to provoke their antitumor and antiviral activities." @default.
• W2912832580 created "2019-02-21" @default.
• W2912832580 creator A5016613733 @default.
• W2912832580 creator A5035978969 @default.
• W2912832580 creator A5045345356 @default.
• W2912832580 creator A5056197706 @default.
• W2912832580 creator A5062502233 @default.
• W2912832580 creator A5076703242 @default.
• W2912832580 date "2019-02-02" @default.
• W2912832580 modified "2023-10-16" @default.
• W2912832580 title "mTOR Signaling pathway as a master regulator of memory CD8 ⁺ T‐cells, Th17, and NK cells development and their functional properties" @default.
• W2912832580 cites W1501087544 @default.
• W2912832580 cites W1556867369 @default.
• W2912832580 cites W1568778024 @default.
• W2912832580 cites W1663833839 @default.
• W2912832580 cites W1850292730 @default.
• W2912832580 cites W1882193637 @default.
• W2912832580 cites W1903749320 @default.
• W2912832580 cites W1918052238 @default.
• W2912832580 cites W1945715178 @default.
• W2912832580 cites W1964983320 @default.
• W2912832580 cites W1968183881 @default.
• W2912832580 cites W1972092098 @default.
• W2912832580 cites W1974942240 @default.
• W2912832580 cites W1976785514 @default.
• W2912832580 cites W1977435414 @default.
• W2912832580 cites W1981629491 @default.
• W2912832580 cites W1981904703 @default.
• W2912832580 cites W1982219839 @default.
• W2912832580 cites W1982704558 @default.
• W2912832580 cites W1983698019 @default.
• W2912832580 cites W1985294654 @default.
• W2912832580 cites W1988181926 @default.
• W2912832580 cites W1990555844 @default.
• W2912832580 cites W1991088949 @default.
• W2912832580 cites W1993686673 @default.
• W2912832580 cites W1997553523 @default.
• W2912832580 cites W1998052953 @default.
• W2912832580 cites W1999324987 @default.
• W2912832580 cites W2000731858 @default.
• W2912832580 cites W2001307074 @default.
• W2912832580 cites W2002226709 @default.
• W2912832580 cites W2004629226 @default.
• W2912832580 cites W2004663864 @default.
• W2912832580 cites W2007711648 @default.
• W2912832580 cites W2010498205 @default.
• W2912832580 cites W2010665897 @default.
• W2912832580 cites W2011239505 @default.
• W2912832580 cites W2016804485 @default.
• W2912832580 cites W2018553282 @default.
• W2912832580 cites W2019077533 @default.
• W2912832580 cites W2022707702 @default.
• W2912832580 cites W2022739232 @default.
• W2912832580 cites W2027132663 @default.
• W2912832580 cites W2028298372 @default.
• W2912832580 cites W2031122515 @default.
• W2912832580 cites W2033223710 @default.
• W2912832580 cites W2033505817 @default.
• W2912832580 cites W2034605152 @default.
• W2912832580 cites W2037608249 @default.
• W2912832580 cites W2039566168 @default.
• W2912832580 cites W2043793366 @default.
• W2912832580 cites W2045415588 @default.
• W2912832580 cites W2047904857 @default.
• W2912832580 cites W2050209022 @default.
• W2912832580 cites W2056137479 @default.
• W2912832580 cites W2056721231 @default.
• W2912832580 cites W2057718072 @default.
• W2912832580 cites W2059689009 @default.
• W2912832580 cites W2064282763 @default.
• W2912832580 cites W2064876347 @default.
• W2912832580 cites W2067980538 @default.
• W2912832580 cites W2068055816 @default.
• W2912832580 cites W2071548401 @default.
• W2912832580 cites W2080196128 @default.
• W2912832580 cites W2081061928 @default.
• W2912832580 cites W2082827804 @default.
• W2912832580 cites W2085441977 @default.
• W2912832580 cites W2085887337 @default.
• W2912832580 cites W2085918020 @default.
• W2912832580 cites W2090648684 @default.
• W2912832580 cites W2091451666 @default.
• W2912832580 cites W2093943334 @default.
• W2912832580 cites W2100244924 @default.
• W2912832580 cites W2100714842 @default.
• W2912832580 cites W2102906934 @default.
• W2912832580 cites W2104156406 @default.
• W2912832580 cites W2104825199 @default.
• W2912832580 cites W2105910944 @default.
• W2912832580 cites W2110641805 @default.
• W2912832580 cites W2115675485 @default.
• W2912832580 cites W2119319172 @default.
• W2912832580 cites W2122783053 @default.
• W2912832580 cites W2123639873 @default.
• W2912832580 cites W2126487427 @default.
• W2912832580 cites W2127063807 @default.
• W2912832580 cites W2129860342 @default.
• W2912832580 cites W2131167502 @default.

• next